A5045810532- RNA and protein synthesis mechanisms
- Fluoride Effects and Removal
- DNA and Nucleic Acid Chemistry
- Glycosylation and Glycoproteins Research
- Photodynamic Therapy Research Studies
- Toxin Mechanisms and Immunotoxins
- Anesthesia and Neurotoxicity Research
- X-ray Diffraction in Crystallography
- Lipid Membrane Structure and Behavior
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Transgenic Plants and Applications
- Carbohydrate Chemistry and Synthesis
- Origins and Evolution of Life
- Metal complexes synthesis and properties
- Advanced biosensing and bioanalysis techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Molecular spectroscopy and chirality
- Amino Acid Enzymes and Metabolism
- Photochemistry and Electron Transfer Studies
- Retinoids in leukemia and cellular processes
- Arsenic contamination and mitigation
- Bacterial Genetics and Biotechnology
University of Kalyani
2025
Indian Institute of Science Education and Research Pune
2020-2022
Visva-Bharati University
2010-2020
Indian Institute of Science Bangalore
1987-2019
Bangalore University
2017
North Eastern Hill University
2014-2015
Christian Medical College & Hospital
1975
Christian Medical College
1975
Max Planck Institute for Biophysical Chemistry
1970-1972
Max Planck Institute for Physics
1970-1971
A modern day light microscope has evolved from a tool devoted to making primarily empirical observations what is now sophisticated , quantitative device that an integral part of both physical and life science research. Nowadays, microscopes are found in nearly every experimental laboratory. However, despite their prevalent use capturing quantifying scientific phenomena, neither thorough understanding the principles underlying imaging techniques nor appropriate knowledge how calibrate,...
Background: Bacteria resist drugs by employing new resistance mechanisms, leading to prolonged infection and complexity in therapeutic prognosis that concordantly decreases drug efficacy. In recent years, nanotechnology has gained immense popularity for the development of delivery systems combat global pharmaceutical crisis multi-drug resistance. Objective: The present work aimed focus on green chemistry-based synthesis silver nanoparticles (AgNPs) using phytocompound chlorophyllin form...
Abstract An easily synthesized fluorescein‐based luminescent dye has been utilized for the dual‐mode detection of histamine at nanomolar concentrations pH 7.0 in water. The specific response to was achieved by imidazole‐catalyzed ‘imine formation’ reaction. protocol subsequently applied estimation complex biological milieu such as human blood serum and urine samples. Furthermore, dose‐dependent cellular uptake de novo synthesis (by thapsigargin treatment) visualized RAW 264.7, a mouse...
Copper(ii) complexes [Cu(L1/L2/L3)(A)] (1-3), where H2A·HCl is a vitamin B6 Schiff base, viz. 3-hydroxy-5-(hydroxymethyl)-4-(((2-hydroxyphenyl)imino)methyl)-2-methylpyridin-1-ium chloride, L1 and L2 are 2-(2-pyridyl)benzimidazole based borondipyrromethene (BODIPY) ligands L3 2-(2-pyridyl)benzimidazole, were prepared, characterized their visible light-induced anti-cancer activity was studied. Complex 3, by X-ray crystallography, exhibits distorted square-pyramidal geometry for copper (τ =...
The thermodynamics of the binding derivatives galactose and lactose to a 14 kDa beta-galactoside-binding lectin (L-14) from sheep spleen has been studied in 10 nM phosphate/150 mM NaCl/10 beta-mercaptoethanol buffer, pH 7.4, temperature range 285-300 K using titration calorimetry. single-site constants various sugars for were following order: N-acetyl-lactosamine thiodigalactoside > 4-methylumbelliferyl lactoside alpha-D-galactoside methyl-alpha-galactose methyl-beta-galactose....
Iron(III) complexes of a vitamin B 6 Schiff base and NNN ‐donor ligands with pendant boron‐dipyrromethene (BODIPY) moieties; namely, [Fe(L 1–3 )(L 4,5 )](NO 3 ) ( 1 – 4 ), where L is benzyl‐bis[(pyridin‐2‐yl)methyl]methanamine (bzdpa in 2 noniodinated BODIPY‐appended dipicolylamine ligand (in , the diiodinated BODIPY analogue base, namely 3‐hydroxy‐5(hydroxymethyl)‐4‐{[(2‐hydroxyphenyl)imino]methyl}‐2‐methylpyridine 5 2‐[(2‐hydroxyphenylimino)‐methyl]phenol as nonpyridoxal were prepared,...
Abstract A series of complexes Au(III) with nucleosides and nucleotides their methyl derivatives in different stoichiometry have been prepared. Ultraviolet, visible, ir, nmr studies performed to determine the site binding these ligands metal ion. In (1:4) Au(III): guanosine complex, N 7 is site, whereas at 1:1 a bidentate type chelation through C 6 O observed. ‐NH 2 favored over 1 as coordinating all adenosine complex. Inosine binds r = 1. cytidine, thymidine reacts only high pH. case...
ABSTRACT A significant level of reactive oxygen species generation was observed in sodium fluoride (NaF) treated mouse bone marrow cells (BMCs). Reduced glutathione (GSH) as a free radical scavenger could be an important determining factor F‐induced genotoxicity. We therefore attempted to monitor GSH understand the mechanism NaF‐induced NaF injected intra‐peritoneally normal, buthionine sulfoximine (BSO) or N ‐acetyl‐ l ‐cysteine (NAC) mice ( n = 5). After 13 h NaF‐treatment BMCs were...
Fluoride is an essential trace element but also environmental contaminant with major sources of exposure being drinking water, food and pesticides. Previous studies showed that sodium fluoride (NaF) at 5 mM or more required to induce apoptosis chromosome aberrations proposed DNA damage play important role in toxicity excessive fluoride. The aim this study directed understand the nature DNA-lesions induced by NaF allowing its interaction radiation DNA-lesions. was used after observing...
Treatment of mice with 15 mg l(-1) sodium fluoride (NaF) for 30 days increased the number cell death, chromosomal aberrations (CAs) and 'cells chromatid breaks' (aberrant cells) compared control. The present study was intended to determine whether (F)-induced genotoxicity could be reduced by substituting high F-containing water after safe drinking water, containing 0.1 F ions l(-1). A significant fall in percentage CAs aberrant cells withdrawal F-treatment following treatment observed which...
Interferon-gamma (Ifnγ), a key macrophage activating cytokine, plays pleiotropic roles in host immunity. In this study, the ability of Ifnγ to induce aggregation resident mouse adherent peritoneal exudate cells (APECs), consisting primarily macrophages, was investigated. Cell-cell interactions involve adhesion molecules and, upon addition Ifnγ, CD11b re-localizes preferentially sites interaction on APECs. A functional role enhancing is demonstrated using Reopro, blocking reagent, and siRNA...
Abstract Copper(II) and zinc(II) β‐diketonates of N,N‐donor ligands, viz . [Cu(dppz)(cur)](NO 3 ) ( 1 ), [Cu(acdppz)(cur)](NO 2 [Cu(acdppz)(acac)](NO [Zn(dppz)(cur)](NO 4 [Zn(acdppz)(cur)](NO 5 where dppz is dipyrido[3,2‐a:2’,3’‐c]phenazine, acdppz 11‐(9‐acridinyl)dipyrido[3,2‐ a :2 ’, ’ ‐ c ]phenazine, cur acac are mono‐deprotonated curcumin (Hcur) acetyl acetone (Hacac), were synthesized, characterized their photocytotoxicity studied. An analogue complex , [Cu(acdppz)(acac)(H O)]Cl 1/2 (NO...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-interacting oligoribonucleotides. I. Absorption and optical rotatory dispersion of 2'-5'-and 3'-5'-oligoguanylic acidsS. K. PodderCite this: Biochemistry 1971, 10, 12, 2415–2423Publication Date (Print):June 8, 1971Publication History Published online1 May 2002Published inissue 8 June 1971https://pubs.acs.org/doi/10.1021/bi00788a036https://doi.org/10.1021/bi00788a036research-articleACS PublicationsRequest reuse permissionsArticle...
Background: Conventional cancer therapies such as chemotherapy and radiotherapy are often characterised by lack of tumor specificity, increased resistance tumors to drugs, failure detect metastases undesirable side effects. Several years back, William Coley's pioneering work on the use bacteria opened up new field immunotherapy. The search for alternative better strategies in treatment is an ongoing process. Methods: Articles related therapeutic efficacies different bacterial species against...