Herein, we synthesized a pair of oxidized bisindolyl derivatives with anthracene (probe 1) and pyrene 2) fluorophores for selective protein aggregate detection, crucial in disorders like Alzheimer's disease. Probe 1 exhibited significant "turn-on" response (∼12-fold) concomitant red shift (∼21 nm) lysozyme aggregates, while showing ∼3-fold fluorescence enhancement insulin indicating high selectivity aggregated proteins. 2 showed similar responses but less preference, as compared to probe 1....

Selective detection of nitro-aromatic compounds (NACs) at nanomolar concentration is achieved for the first time in multiple media including water, micelles or organogels as well using test strips. Mechanism interaction NACs with highly fluorescent p-phenylenevinylene-based molecules has been described electron transfer phenomenon from electron-rich chromophoric probe to deficient NACs. The selectivity sensing guided by pKa probes under consideration. TNP-induced selective gel-to-sol...

A pyrene-based excited-state intramolecular proton transfer (ESIPT) active probe PMHMP was synthesized, characterized, and employed for the ppb-level, dual-mode, high-fidelity detection of Cu2+ (LOD: 7.8 ppb) Zn2+ ions 4.2 in acetonitrile medium. The colorless solution turned yellow upon addition Cu2+, suggesting its ratiometric, naked-eye sensing. On contrary, displayed concentration-dependent fluorescence rise till a 0.5 mole fraction subsequent quenching. Mechanistic investigations...

Tetrazole-based easily synthesizable fluorogenic probes have been developed that can form self-assembled nanostructures in the aqueous medium. Though compounds could achieve detection of cyanide ions apolar solvents, such as, THF, significant interference was observed from other basic anions, as F-, AcO-, H2PO4-, etc. On hand, a highly specific response for CN- However, sensitivity so poor it hardly be useful real-life sample analysis. Interestingly, co-assembly probe molecules with...

Herein, we have designed and synthesized two oxidized bis(indolyl)methane derivatives with pyrene anthracene as signaling moieties. Both the amphiphilic compounds exhibited microenvironment-sensitive (pH, temperature, polarity, etc.) nanoscopic aggregate formation in an aqueous medium. It has been observed that excitation of either monomer species or aggregates is possible by choosing a suitable channel. Upon photoexcitation, showed turn-off response specifically for Hg2+ ions. On other...

Abstract In this work, we conducted a comparative analysis of the metal ion sensing capabilities two pyridine‐end oligo p‐phenylenevinylene compounds featuring different alkyl substituents (−C 4 H 9 and −C 16 33 ) within micelle medium. Our findings revealed correlation between positioning probe molecules length chains, impacting their self‐assembly tendencies optical characteristics. The compound with shorter chains demonstrated superior affinity towards Hg 2+ ions, whereas exposure to...

An AIE-active pyrene-terpyridine derivative, (4'-(pyren-1-yl)-2,2':6',2''-terpyridine) (1) was found to form nanoaggregate in an aqueous medium. The probe involved hydrogen bonding with solvent molecules that modulated the charge transfer behavior and consequently resulted different spectroscopic due formation of fluorescent organic nanoparticles (FONs). In presence Cu

The compartmentalization effect of microheterogeneous systems, like surfactant aggregates, showcases altered optoelectronic properties a perylene diimide-based chromogenic dye (PDI-Ala) compared to bulk water.

Herein, we report the design and synthesis of a red luminescent ruthenium (Ru) complex with imidazophenanthroline as chelating ligand. The metal showed unique concentration-dependent distinct optical response in presence target analyte, Na2S. At lower concentration (micromolar range), addition Na2S resulted decrease absorption maximum diminution luminescence intensity. On contrary, bathochromic shift UV–visible spectrum turn-on was noticed upon excess (millimolar range). detailed mechanistic...

Abstract This study explores the impact of incorporating oxyethylene (OE) chains into rhodamine‐based dye molecules for enhancement photophysical properties in context chemical sensing. The introduction OE provides several advantages, including improved water solubility, photostability and resistance to self‐assembled nanoaggregates formation. Despite these, compound with showed poor response (~2‐fold) towards Hg 2+ ions than that dimeric probe (~20 fold) no such substituents. Notably, shows...

In this study, we designed and synthesized metalloporphyrin derivatives (with Ni Zn) specifically intended for the fluorescence detection of nicotine in aqueous solutions. Our results showcased a notable selectivity over other naturally occurring food toxins, exhibiting an exceptional sensitivity with limit as low 7.2 nM. Through mechanistic investigations (1H NMR, FT-IR, etc.), elucidated binding mechanism, revealing specific interaction between pyridine ring metal center, while N atom...

The amphiphilic probe selectively exhibits flourescence response towards uric acid and phytic acid, enabling differentiation via distinct emission channels, allowing for low detection limits on-site monitoring with pre-coated paper strips.

We present the selective sensing of multiple transition metal ions in water using a synthetic single probe. The probe is made up pyrene and pyridine as signaling interacting moiety, respectively. sensor showed different responses toward just by varying medium detection. In organic solvent (acetonitrile), detection Hg2+ ion. water, fluorescence quenching was observed with three ions, Cu2+, Hg2+, Ni2+. Further, surface charge on micellar aggregates, could detect discriminate above-mentioned...

New rhodamine based molecules have been designed as dual probes for the ppb-level selective detection of Hg2+ and F− ions in aqueous medium at physiological pH 7.4. The such a way to utilize both properties metal ion induced ‘turn-on’ mechanism spirolactam ring opening moiety reaction cleavage O-silyl bond presence fluoride ion. synthesized conveniently by coupling hydrazone with protected mono- di-hydroxybenzaldehydes. Both showed due upon treatment added However, ring. two mechanisms...

A donor-acceptor based conjugated microporous polymer, PER@NiP-CMOP-1, has been synthesized which can achieve highly sensitive stereo-specific "Turn ON" biosensing of an aminoglycoside up to the ppb level. The coordination-driven inhibition photo-induced electron transfer (d-PET) for d-electrons and rotational freezing are key factors recovery emission.

In this report, three oxidized diindolylarylmethane (DIAM)-based chromogenic probes (designated as 1, 2, and 3) have been developed for the simultaneous dual-channel detection of cyanide (LOD: 6.2 ppb) bisulfate 8.7 ions at pH 7.4.

An easily synthesizable pyrene-based amphiphilic probe (Pybpa) has been developed, which exhibited no responses with metal ions in the pure aqueous medium despite possessing a ion-chelating bispicolyl unit. We believe that spontaneous aggregation of Pybpa makes ion binding unit not accessible to ions. However, sensitivity and selectivity toward Zn2+ drastically improve presence serum albumin protein, HSA. The differences microenvironment inside protein cavity, terms local polarity,...

Carbazole-based amphiphilic molecules have been synthesized that can form fluorescent organic nanoparticles in the aqueous medium and generate distinct optical responses via restricted intermolecular rotation (RIR). The showed polarity-independent, reversible, fluorescence switching between cyan blue on temperature change. Unlike other systems, here we observe ratiometric, reversible response with temperature. Such kind of intensity ratio measurement instead analysis at a single wavelength...