A5010278693- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Crystallography and molecular interactions
- Photodynamic Therapy Research Studies
- Molecular Sensors and Ion Detection
- Click Chemistry and Applications
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Ferrocene Chemistry and Applications
- Curcumin's Biomedical Applications
- DNA and Nucleic Acid Chemistry
- Asymmetric Hydrogenation and Catalysis
- Nanocluster Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Synthesis and characterization of novel inorganic/organometallic compounds
- Vanadium and Halogenation Chemistry
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Nanoparticle-Based Drug Delivery
- Synthesis and biological activity
- Metal-Catalyzed Oxygenation Mechanisms
Indian Institute of Technology BHU
2021-2025
Banaras Hindu University
2021-2025
University of Warwick
2018-2023
Indian Institute of Technology Bombay
2022
University of Göttingen
2020-2021
Coventry (United Kingdom)
2018-2020
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2020
Indian Institute of Science Bangalore
2012-2019
Johns Hopkins University
2016-2019
Bangalore University
2015-2016
ConspectusCurcumin is a polyphenolic species. As an active ingredient of turmeric, it well-known for its traditional medicinal properties. The therapeutic values include antioxidant, anti-inflammatory, antiseptic, and anticancer activity with the last being primarily due to inhibition transcription factor NF-κB besides affecting several biological pathways arrest tumor growth progression. Curcumin all these positive qualities has only remained potential candidate cancer treatment over years...
Abstract Photocatalytic anticancer profile of a Ir III photocatalyst ( Ir3 ) with strong light absorption, high turnover frequency, and excellent biocompatibility is reported. showed selective photo‐cytotoxicity against cisplatin‐ sorafenib‐resistant cell lines while remaining dormant to normal in the dark. exhibited photo‐catalytic oxidation cellular co‐enzyme, reduced nicotinamide adenine dinucleotide phosphate (NADPH), amino acids via single electron transfer mechanism. The photo‐induced...
The development of PtIV prodrugs that are reduced into the therapeutically active PtII species within tumor microenvironment has received much research interest. In order to provide spatial and temporal control over treatment, there is a high demand for compounds could be selectively activated upon irradiation. Despite recent progress, majority complexes excited with ultraviolet or blue light, limiting use such superficial application. To overcome this limitation, herein, first example...
Abstract An organoiridium–albumin bioconjugate ( Ir1‐HSA ) was synthesized by reaction of a pendant maleimide ligand with human serum albumin. The phosphorescence enhanced significantly compared to parent complex Ir1 . long lifetime and high 1 O 2 quantum yield are highly favorable properties for photodynamic therapy. mainly accumulated in the nucleus living cancer cells showed remarkable photocytotoxicity against range cell lines tumor spheroids (light IC 50 ; 0.8–5 μ m , photo‐cytotoxicity...
Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells visible light of 400–700 nm giving IC50 = 8.2 ± 0.2 μM its degradation is arrested on formation photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC50 3.3 0.4 μM), while both are less toxic the dark.
Mixed-ligand ferrocenyl copper(<sc>ii</sc>) complexes target the mitochondria of cancer cells showing remarkable cytotoxicity against HeLa and MCF-7 while being much less toxic to MCF-10A normal cells.
Abstract Quantifying the content of metal‐based anticancer drugs within single cancer cells remains a challenge. Here, we used single‐cell inductively coupled plasma mass spectrometry to study uptake and retention mononuclear ( Ir1 ) dinuclear Ir2 Ir III photoredox catalysts. This method allowed rapid precise quantification drug in individual cells. Importantly, showed significant synergism but not an additive effect for NAD(P)H photocatalytic oxidation. The lysosome‐targeting low dark...
Herein, we have compared the effectivity of light-based photoactivated cancer therapy and ultrasound-based sonodynamic with Re(I)-tricarbonyl complexes (Re1–Re3) against cells. The observed photophysical TD-DFT calculations indicated potential Re1–Re3 to act as good anticancer agents under visible light/ultrasound exposure. Re1 did not display any dark- or light- ultrasound-triggered activity. However, Re2 Re3 displayed concentration-dependent activity upon light ultrasound Interestingly,...
Growing challenges with antibiotic resistance pose immense in combating microbial infections and biofilm prevention on medical devices. Lately, antibacterial photodynamic therapy (aPDT) is now emerging as an alternative to overcome this problem. Herein, we synthesized characterized four Ru(II)-complexes, viz., [Ru(ph-tpy)(bpy)Cl]PF6 (Ru1), [Ru(ph-tpy)(dpq)Cl]PF6 (Ru2), [Ru(ph-tpy)(dppz)Cl]PF6 (Ru3), [Ru(ph-tpy)(dppn)Cl]PF6 (Ru4) (where 4′-phenyl-2,2′:6′,2″-terpyridine = ph-tpy;...
Coumarin 6 appended Ir( iii ) photocatalysts exhibited light activated anticancer effects against cancer cells via mitochondrial depolarization driven apoptosis by inducing type-I (NADH oxidation) and type-II (ROS generation) mechanisms.
The relentless increase in drug resistance of platinum-based chemotherapeutics has opened the scope for other new cancer therapies with novel mechanisms action (MoA). Recently, photocatalytic therapy, an intrusive catalytic treatment, is receiving significant interest due to its multitargeting cell death mechanism high selectivity. Here, we report synthesis and characterization three photoresponsive Ru(II) complexes, viz., [Ru(ph-tpy)(bpy)Cl]PF6 (Ru1), [Ru(ph-tpy)(phen)Cl]PF6 (Ru2),...
The design of the dinuclear Ru(II) complex (Ru2) with strong near-infrared (NIR) absorption properties has been reported for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization ability and photocatalytic activity toward intracellular biomolecules. showed impressive light-triggered under normoxia hypoxia compared clinically used photosensitizer Chlorin e6. mechanistic studies that induced redox imbalance...
A new cell permeable rhodamine based Schiff base (<bold>L</bold>) senses nanomolar level of Al<sup>3+</sup> ions through CHEF process and its Al(<sc>iii</sc>) complex (<bold>2</bold>) behaves as a highly F<sup>−</sup> selective biomarker fluorescence quenching in HEPES buffer.
Lanthanide(III) complexes [Ln(R-tpy)(cur)(NO3)2] (Ln = La(III) in 1, 2; Gd(III) 5, 6) and [Ln(R-tpy)(scur)(NO3)2] 3, 4; 7, 8), where R-tpy is 4′-phenyl-2,2′:6′,2′′-terpyridine (ph-tpy 7), 4′-(1-pyrenyl)-2,2′:6′,2′′-terpyridine (py-tpy 2, 4, 6, Hcur curcumin (in Hscur diglucosylcurcumin were prepared their DNA photocleavage activity photocytotoxicity studied. Complexes [La(ph-tpy)(cur)(NO3)2] (1) [Gd(ph-tpy)(cur)(NO3)2] (5) structurally characterized. The aqueous-DMF showed an absorption band...
An oxovanadium(<sc>iv</sc>) Schiff base vitamin-B6 complex of (acridinyl)dipyridophenazine shows ER-targeted photo-induced anticancer activity while being non-toxic in the dark and to normal cells.
Ternary cobalt(III) complexes of curcumin (Hcur) and mitocurcumin [Hmitocur, a dicationic bis(triphenylphosphonium) derivative curcumin] having tetradentate phenolate-based ligand (H2L), namely, [Co(cur)(L)] (1) [Co(mitocur)(L)]Cl2 (2), were prepared structurally characterized, their photoinduced cytotoxicity was studied. The diamagnetic show an irreversible Co(III)–Co(II) redox response quasireversible curcuminoid-based reduction near −1.45 −1.74 V SCE, respectively, in DMF/0.1 M...
A novel cyanine-rhenium(I) tricarbonyl complex is developed as a potent sonosensitizer and sono-activatable CO-releasing agent for synergistic sonodynamic therapy CO gas of cancer. The induced ferroptosis the mode cell death.
A novel axisymmetric bis-tridentate Ir(III) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity toward drug-resistant cancer cells under normoxia hypoxia. The photoactivated anticancer mechanism of were investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia drug resistance-related problems clinical therapy.
We have red-shifted the light absorbance property of a Re(I)-tricarbonyl complex via distant conjugation ferrocene moiety and developed novel ReFctp, [Re(Fctp)(CO)3Cl], where Fctp = 4′-ferrocenyl-2,2′:6′,2″-terpyridine. ReFctp showed green to red absorption ability blue emission, indicating its potential for photodynamic therapy (PDT) application. The introduced ferrocene-based transitions, which lie at higher wavelength within PDT therapeutic window. time-dependent density functional theory...