A5001724504- Nanoplatforms for cancer theranostics
- Hydrology and Watershed Management Studies
- Nanoparticle-Based Drug Delivery
- Hydrological Forecasting Using AI
- Luminescence and Fluorescent Materials
- interferon and immune responses
- Photodynamic Therapy Research Studies
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Soil erosion and sediment transport
- Cancer Immunotherapy and Biomarkers
- Lanthanide and Transition Metal Complexes
- Peptidase Inhibition and Analysis
- Nanocluster Synthesis and Applications
- Hydrology and Sediment Transport Processes
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- RNA modifications and cancer
- Web Data Mining and Analysis
- Flood Risk Assessment and Management
- Neural and Behavioral Psychology Studies
- Human Motion and Animation
- Advancements in PLL and VCO Technologies
- Photonic Crystal and Fiber Optics
- IL-33, ST2, and ILC Pathways
Institute of Chemistry
2022-2025
Beijing National Laboratory for Molecular Sciences
2023-2025
Chinese Academy of Sciences
2023-2025
University of Chinese Academy of Sciences
2022-2024
State Key Laboratory of Polymer Physics and Chemistry
2022-2024
Ningxia University
2020-2023
University of Shanghai for Science and Technology
2023
Xidian University
2023
Sun Yat-sen Memorial Hospital
2020-2022
Sun Yat-sen University
2020-2022
Abstract Photodynamic therapy (PDT) and photothermal (PTT) leverage reactive oxygen species (ROS) control local hyperthermia by photosensitizer to perturb intracellular redox equilibrium, inducing DNA damage in both mitochondria nucleus, activating the cGAS‐STING pathway, ultimately eliciting antitumor immune responses. However, current photosensitizers are encumbered limitations such as suboptimal tumor targeting, aggregation‐caused quenching (ACQ), restricted excitation emission...
Abstract Selective activation of Pt(IV) prodrugs within tumors is particularly attractive because their low damage to normal tissues. However, current common via chemical/photoreduction into Pt(II) counterparts limited by undesirable spatial–temporal control over this reduction process and the ineffective tissue penetration depth light. Here, a pseudo‐conjugated‐polymer designed Stille polymerization, resulting in PSP‐Pt with prodrug oxaliplatin (Oxa(IV)) polymer main chain that can be...
The development of PtIV prodrugs that are reduced into the therapeutically active PtII species within tumor microenvironment has received much research interest. In order to provide spatial and temporal control over treatment, there is a high demand for compounds could be selectively activated upon irradiation. Despite recent progress, majority complexes excited with ultraviolet or blue light, limiting use such superficial application. To overcome this limitation, herein, first example...
Abstract Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy cuproptosis remains limited by poor delivery efficiency copper ion carriers. Herein, complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver into cells to induce cuproptosis. NP demonstrate stimulus‐responsive release complexes, which results mitochondrial dysfunction and promotes aggregation lipoylated dihydrolipoamide...
Internet of Things (IoT) plays an important role in the development various fields. The increasing scale and scope applications make a great demand IoT data exchange recent years. Meanwhile, number platforms which dedicated to connecting distributed sources are emerging. In such platform, service providers can search sets that they need. However, centralized infrastructure cannot provide enough trust as third-party intermediaries for exchange. As result, most unable satisfy complex...
Flow forecasting is an essential topic for flood prevention and mitigation. This study utilizes a data-driven approach, the Long Short-Term Memory neural network (LSTM), to simulate rainfall–runoff relationships catchments with different climate conditions. The LSTM method presented was tested in three distinct zones China. recurrent (RNN) adopted comparison verify superiority of model terms time series prediction problems. results were also compared widely used process-based model,...
Tumor metastases and reoccurrences are considered the leading cause of cancer-associated deaths. While highly efficient treatments for eradication primary tumors have been developed, treatment secondary or metastatic remains poorly accessible. Over past years, compounds that intervene through cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) signaling pathway against tumor emerged with potential clinical development. stimulatory DNAs demonstrated activation this pathway, these...
Abstract Photodynamic therapy (PDT), as a new type of light‐mediated reactive oxygen species (ROS) cancer therapy, has the advantages high therapeutic efficiency, non‐resistance, and less trauma than traditional such surgery, radiotherapy, chemotherapy. However, oxygen‐dependent PDT further exacerbates tumor metastasis. To this end, strategy that circumvents metastasis to improve efficacy is proposed. Herein, near‐infrared light‐activated photosensitive polymer synthesized branched...
Large Language Models (LLMs) are becoming increasingly smart and autonomous, targeting real-world pragmatic missions beyond traditional NLP tasks. As a result, there has been an urgent need to evaluate LLMs as agents on challenging tasks in interactive environments. We present AgentBench, multi-dimensional evolving benchmark that currently consists of 8 distinct environments assess LLM-as-Agent's reasoning decision-making abilities multi-turn open-ended generation setting. Our extensive test...
Mild-heat photothermal antibacterial therapy avoids heat-induced damage to normal tissues but causes bacterial tolerance. The use of in synergy with chemodynamic is expected address this issue. Herein, two pseudo-conjugated polymers P
The clinical application of cisplatin (CisPt) is limited by its dose-dependent toxicity. To overcome this, we developed reduction-responsive nanoparticles (NP(3S)s) for the targeted delivery a platinum(IV) (Pt(IV)) prodrug to improve efficacy and reduce NP(3S)s could release Pt(II) hydrogen sulfide (H2S) upon encountering intracellular glutathione, leading potent anticancer effects. Notably, induced DNA damage activated STING pathway, which known promoter T cell activation. Comparative RNA...
Abstract Cationic polymers have great potential for cancer therapy due to their unique interactions with cells. However, clinical application remains limited by high toxicity. Here we show a cell membrane-targeting cationic polymer antineoplastic activity (P mt ) and second near-infrared (NIR-II) fluorescent biodegradable photosensitizer Bodipy units reactive oxygen species (ROS) responsive thioketal bonds ). Subsequently, these two can self-assemble into nanoparticles (denoted mt-NP which...
Abstract Nanotheranostics, which integrate diagnostic and therapeutic functionalities, offer significant potential for tumor treatment. However, current nanotheranostic systems typically involve multiple molecules, each providing a singular or function, leading to challenges such as complex structural composition, poor targeting efficiency, lack of spatiotemporal control, dependence on single modality. This study introduces NP RBOXA , nanoparticle functionalized with surface‐bound cRGD...
The cGAS-STING pathway, as a vital innate immune signaling has attracted considerable attention in tumor immunotherapy research. However, STING agonists are generally incapable of targeting tumors, thus limiting their clinical applications. Here, photodynamic polymer (P1) is designed to electrostatically couple with 56MESS-a cationic platinum (II) agent-to form NPPDT -56MESS. accumulation -56MESS the tumors increases efficacy and decreases systemic toxicity drugs. Moreover, generates...
Abstract Poor immunogenicity seriously hampers the broader implementation of antitumor immunotherapy. Enhanced capable achieving greater immunity is urgently required. Here, a novel polymer that contains hydrophobic ferrocene (Fc) units and thioketal bonds in main chain, which further delivered prodrug oxaliplatin artesunate, i.e., Artoxplatin, to cancer cells described. This with Fc nanoparticle can work as polyigniter spark peroxide Artoxplatin generate abundant reactive oxygen species...
Recently, various technologies for targeted gene release in cancer treatment have emerged. However, most of these strategies are facing the challenge untraceable distribution and poor antitumour effects. In this study, we constructed a delivery system that integrated series components to assemble multifunctional NPs, providing promising theranostic nanoplatform hepatocellular carcinoma (HCC) therapy. Cationized amylose (CA), superparamagnetic iron oxide (SPIO) nanoparticles (NPs),...
Diffuse alveolar damage (DAD) triggers neutrophilic inflammation in damaged tissues of the lung, but little is known about distinct roles tissue structural cells modulating recruitment neutrophils to areas. Here, by combining single-cell and spatial transcriptomics, using quantitative assays, we systematically analyze inflammatory cell states a mouse model DAD-induced after aerosolized intratracheal inoculation with ricin toxin. We show that homeostatic resident fibroblasts switch...
Tumor metastases and reoccurrence are considered the leading causes of cancer-associated deaths. As an emerging therapeutic method, increasing research efforts have been devoted to immunogenic cell death (ICD)-inducing compounds solve challenge. The clinically approved chemotherapeutic Pt complexes not or only poorly able trigger ICD. Herein, axial functionalization Pt(II) complex cisplatin with perfluorocarbon chains into ICD-inducing Pt(IV) prodrugs is reported. Strikingly, while as well...
Schizophrenia is a common mental disorder with unclear mechanisms. Oxidative stress and neuroinflammation play important roles in the pathological process of schizophrenia. Superoxide anion (O2•–) an oxidative biomarker vivo. However, due to existence blood–brain barrier (BBB), few near-infrared (NIR) fluorescent probes have been used for sensing detection O2•– brain. With this research, we developed first probe (named CT–CF3) noninvasive endogenous brain mice. Enabling fluorescence...
Abstract Sonodynamic therapy (SDT) has good feasibility to deeply seated infections, but SDT alone is insufficient being highly effective against multidrug‐resistant (MDR) bacteria. combined with triphenylphosphanium bromide (P + Ph 3 Br − ) expected solve this problem. This work develops a pseudo‐conjugated polymer P FCPS‐P containing cationic ‐modified sonosensitizer FCPS (FCPS‐P) and ROS‐sensitive thioketal bonds. assembled DSPE‐mPEG 2000 generate nanoparticle NP . effect generates ROS...
Abstract Rainfall–runoff modeling is a complex hydrological issue that still has room for improvement. This study developed coupled bidirectional long short‐term memory (LSTM) with sequence‐to‐sequence (Seq2Seq) learning (BiLSTM‐Seq2seq) model to simulate multi‐step‐ahead runoff flood events. The LSTM Seq2Seq (LSTM‐Seq2Seq) and multilayer perceptron (MLP) was set as benchmarks. results show that: (1) root mean absolute error reduced by approximately 19% up 27%, the Nash–Sutcliffe coefficient...
Physically based distributed hydrological models were used to describe small-scale information in detail. However, the sensitivity of model spatially varied parameters and inputs limits accuracy for application. In this paper, relevant influence factors sensitive analyzed solve problem. First, a set digital elevation (DEM) resolutions channel thresholds generated extract factors. Second, numerical relationship between was established define reasonably. Next, topographic index (TI) computed...