The photoreduction of CO2 to hydrocarbon products has attracted much attention because it provides an avenue directly synthesize value-added carbon-based fuels and feedstocks using solar energy. Among various photocatalysts, graphitic carbon nitride (g-C3N4) emerged as attractive metal-free visible-light photocatalyst due its advantages earth-abundance, nontoxicity, stability. Unfortunately, photocatalytic efficiency is seriously limited by charge carriers' ready recombination their low...

Photothermal therapy holds great promise for cancer treatment due to its effective tumor ablation and minimal invasiveness. Herein a new class of biodegradable photothermal agents with adsorption in both near-infrared-I (NIR-I) NIR-II windows is reported deep therapy. As demonstrated deep-seated ovarian model, using 1064 nm irradiation effectively inhibits progression prolongs survival spans. This work provides design toward more tumors.

Semiconducting polymers (SP) hold great promise for cancer phototherapy due to their excellent optical properties; however, clinical application is still hampered by poor biodegradability. Herein, a self-sacrificially biodegradable pseudo-semiconducting polymer (PSP) NIR-II fluorescence bioimaging, photodynamic immunotherapy, and photoactivated chemotherapy (PACT) reported. The PSP can further co-assemble with an amphiphilic polyester pendant doxorubicin (DOX) in its side chains via reactive...

cGAS-STING pathway, as an essential intracellular immune response has attracted much attention in tumor immunotherapy. However, low metabolic stability of conventional STING agonists limits their clinical application. Recent study shows that chemotherapeutic drugs cisplatin and camptothecin (CPT) can activate pathway induce by DNA damage. Nevertheless, the ability to is so weak new strategies are required improve drug delivery efficiency for enhanced damage, then efficiently pathway. Herein,...

Abstract The key dilemma for green hydrogen production via electrocatalytic water splitting is the high overpotential required anodic oxygen evolution reaction (OER). Co/Fe‐based materials show superior catalytic OER activity to noble metal‐based catalysts, but still lag far behind state‐of‐the‐art Ni/Fe‐based catalysts probably due undesirable side segregation of FeOOH with poor conductivity and unsatisfied structural durability under large current density. Here, a robust durable catalyst...

Photothermal therapy based on conjugated polymers represents a promising antibacterial strategy but still possesses notable limitations. Herein, degradable pseudo (PCPs) containing photothermal molecular backbones and reactive oxygen species (ROS)-sensitive thioketal bonds are designed. Triphenylphosphine (PPh

Photodynamic therapy (PDT) has achieved great success in cancer treatment. Despite its promise, the efficacy of photodynamic immunotherapy can be limited by hypoxia solid tumors which is closely related to abnormal tumor vasculature. These vasculatures are a hallmark most and facilitate immune evasion. Therefore, vascular normalization developed as promising strategy overcome hypoxia, resulting improved therapy. Here, NIR-II bio-degradable pseudo-conjugate polymer (PSP)-based designed...

Abstract Photodynamic therapy (PDT) and photothermal (PTT) leverage reactive oxygen species (ROS) control local hyperthermia by photosensitizer to perturb intracellular redox equilibrium, inducing DNA damage in both mitochondria nucleus, activating the cGAS‐STING pathway, ultimately eliciting antitumor immune responses. However, current photosensitizers are encumbered limitations such as suboptimal tumor targeting, aggregation‐caused quenching (ACQ), restricted excitation emission...

Tumor metastases are considered the leading cause of cancer-associated deaths. While clinically applied drugs have demonstrated to efficiently remove primary tumor, remain poorly accessible. To overcome this limitation, herein, development a theranostic nanomaterial by incorporating chromophore for imaging and photosensitizer treatment metastatic tumor sites is presented. The mechanism action reveals that nanoparticles able intervene local generation cellular damage through photodynamic...

Abstract Selective activation of Pt(IV) prodrugs within tumors is particularly attractive because their low damage to normal tissues. However, current common via chemical/photoreduction into Pt(II) counterparts limited by undesirable spatial–temporal control over this reduction process and the ineffective tissue penetration depth light. Here, a pseudo‐conjugated‐polymer designed Stille polymerization, resulting in PSP‐Pt with prodrug oxaliplatin (Oxa(IV)) polymer main chain that can be...

Abstract Tumor immunotherapy has emerged as one of the most promising clinical techniques to treat cancer tumors. Despite its application, cancerous immunosuppressive microenvironment limits therapeutic efficiency treatment. To generate a stronger immunogenic effect, herein, platinum complex for chemotherapy and BODIPY photosensitizer photodynamic therapy are encapsulated into multimodal type II cell death (ICD) induce nanoparticles. As able ICD, an exceptionally strong immune response is...

The development of PtIV prodrugs that are reduced into the therapeutically active PtII species within tumor microenvironment has received much research interest. In order to provide spatial and temporal control over treatment, there is a high demand for compounds could be selectively activated upon irradiation. Despite recent progress, majority complexes excited with ultraviolet or blue light, limiting use such superficial application. To overcome this limitation, herein, first example...

Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles been widely developed for nanomedicine via chemical conjugation or physical encapsulation bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, tumor-targeting Capitalizing on this, several nanoformulations already clinically approved many others are...

Abstract Developing efficient non‐noble and earth‐abundant hydrogen‐evolving electrocatalysts is highly desirable for improving the energy efficiency of water splitting in base. Molybdenum disulfide (MoS 2 ) a promising candidate, but its catalytic activity kinetically retarded alkaline media due to unfavorable adsorption dissociation feature. A heterogeneous electrocatalyst reported that constructed by selenium‐doped MoS (Se‐MoS particles on 3D interwoven cobalt diselenide (CoSe nanowire...

The catalytic hydrogen-evolving activities of transition-metal phosphides are greatly related to the phosphorus content, but physical origin performance enhancement remains ambiguous, and tuning activity nickel (NiP2 /Ni5 P4 ) challenging due unfavorable H* adsorption. Here, a strategy is introduced integrate P-rich NiP2 P-poor Ni5 into in-plane heterostructures by anion substitution, in which P atoms at interfaces perform as active sites adsorb thus facilitate hydrogen evolution reaction...

Tumor metastases and reoccurrences are considered the leading cause of cancer-associated deaths. While highly efficient treatments for eradication primary tumors have been developed, treatment secondary or metastatic remains poorly accessible. Over past years, compounds that intervene through cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) signaling pathway against tumor emerged with potential clinical development. stimulatory DNAs demonstrated activation this pathway, these...

Abstract STING agonists have made great progress in tumor immunotherapy. However, the inherent instability and low bioavailability limited their wide applications. Herein, a reduction sensitive polymer with pair‐wised carboxyl groups that further encapsulate cationic phenanthriplatin drug (PhenPt) as into nanoparticles (PhenPt NPs) via electrostatic interactions is designed. PhenPt NP can release cancer cells, which then induce DNA damage, activate signaling pathway, stimulate innate...

Recent progress in studying copper-dependent targets and pathways the context of tumor treatment has provided new insights into therapeutic strategies leveraging disease vulnerabilities pharmacological manipulation intratumor copper transportation to improve chemotherapy. Here, we developed reactive oxygen species (ROS)-sensitive nanoparticles loaded with chaperone inhibitor DC_AC50 cisplatin(IV) prodrug. The released can promote a remarkable accumulation intracellular cisplatin through...

Abstract Reactive oxygen species (ROS)‐induced oxidative stress in the endoplasmic reticulum (ER) is generally believed to be an important prerequisite for immunogenic cell death (ICD) which can trigger antitumor immune responses cancer immunotherapy. However, thus far, little known between a certain organelle other than ER and ICD. Herein, polymers preparing ROS‐responsive nanoparticles (NP‐I‐CA‐TPP) with mitochondrial targeting performance as ICD nanoinducers are designed. It that...

Abstract Photodynamic therapy (PDT), as a new type of light‐mediated reactive oxygen species (ROS) cancer therapy, has the advantages high therapeutic efficiency, non‐resistance, and less trauma than traditional such surgery, radiotherapy, chemotherapy. However, oxygen‐dependent PDT further exacerbates tumor metastasis. To this end, strategy that circumvents metastasis to improve efficacy is proposed. Herein, near‐infrared light‐activated photosensitive polymer synthesized branched...

Abstract Recent years have witnessed substantial progress in cancer immunotherapy, specifically T cell‐based therapies. However, the application of cell therapies has been primarily limited to hematologic malignancies, with success treatment solid tumors. The main challenge treating tumor is immune escape, which characterized by reduced antigenicity, diminished immunogenicity, and development suppressive microenvironments. To address these obstacles restore cell‐mediated anti‐tumor...