A5018112071- Effects of Radiation Exposure
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Genetics and Neurodevelopmental Disorders
- Environmental Toxicology and Ecotoxicology
- Ion channel regulation and function
- Radiomics and Machine Learning in Medical Imaging
- Epilepsy research and treatment
- Radioactive contamination and transfer
- Radiation Effects and Dosimetry
- Radioactivity and Radon Measurements
- Nuclear Structure and Function
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
- Ion Transport and Channel Regulation
- Neonatal Respiratory Health Research
- Oral health in cancer treatment
- Polyomavirus and related diseases
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
Pathophysiology, Diagnosis and Treatment of Bone Diseases
2017-2023
Inserm
2005-2022
Centre Léon Bérard
2016-2022
Institut de Radioprotection et de Sûreté Nucléaire
2010-2018
Centre de Recherche en Cancérologie de Lyon
2013-2018
Centre National de la Recherche Scientifique
2014-2015
Génétique Médicale & Génomique Fonctionelle
2013
CEA Cadarache
2012
Institut de Neurobiologie de la Méditerranée
2008
Unité de Neurobiologie des canaux Ioniques et de la Synapse
2008
The rolandic and sylvian fissures divide the human cerebral hemispheres adjacent areas participate in speech processing. relationship of (sylvian) seizure disorders with cognitive impairments is well known, albeit poorly understood. We have identified Xq22 gene SRPX2 as being responsible for seizures (RSs) associated oral dyspraxia mental retardation (MR). a secreted sushi-repeat containing protein expressed neurons adult brain, including area. disease-causing mutation (N327S) resulted...
Mutations in KCNJ2, the gene encoding inward-rectifying K+ channel Kir2.1, cause cardiac, skeletal muscle, and developmental phenotypes of Andersen-Tawil syndrome (ATS; also known as Andersen syndrome). Although pathogenic mechanisms have been proposed for select mutations, a common mechanism has not identified.Seventeen probands presenting with symptoms characteristic ATS were evaluated clinically screened mutations KCNJ2. The results mutation analysis combined those from previously studied...
This paper describes the sequence of construction a cell nuclei classification model by analysis, characterization and shape texture. We describe first elaboration dedicated indexes second associated submodel. Then we present new method texture characterization, based on analysis statistical matrices encoding The various techniques developed in this are systematically compared to previous approaches. In particular, paid special attention results obtained versatile using large range...
In neurons, generation and propagation of action potentials requires the precise accumulation sodium channels at axonal initial segment (AIS) in nodes Ranvier through ankyrin G scaffolding. We found that ankyrin-binding motif Nav1.2 determines channel concentration AIS depends on a glutamate residue (E1111), but also several serine residues (S1112, S1124, S1126). showed phosphorylation these by protein kinase CK2 (CK2) regulates Nav interaction with ankyrins. Furthermore, we observed is...
Human mesial temporal lobe epilepsies (MTLE) are the most frequent form of partial and display pharmacoresistance. The molecular alterations underlying human MTLE remain poorly understood. A two-step transcriptional analysis consisting in cDNA microarray experiments followed by quantitative RT-PCR validations was performed. Because entorhinal cortex (EC) plays an important role pathophysiology usually discloses no detectable or little cell loss, resected EC each corresponding lateral...
Magnetotactic bacteria are able to swim navigating along geomagnetic field lines. They synthesize ferromagnetic nanocrystals that embedded in cytoplasmic membrane invaginations forming magnetosomes. Regularly aligned the cytoplasm cytoskeleton filaments, magnetosome chain effectively forms a compass needle bestowing on their magnetotactic behaviour. A large genomic island, conserved among bacteria, contains genes potentially involved formation. One of genes, mamK has been described as...
The term "bystander effect" is used to describe an effect in which cells that have not been exposed radiation are affected by irradiated though various intracellular signaling mechanisms. In this study we analyzed the kinetics and mechanisms of bystander radioadaptation embryonic zebrafish (ZF4) chronic low dose gamma rays. ZF4 were for 4 hours with total doses irradiation ranging from 0.01–0.1 Gy. two experimental conditions, transfer or culture medium results occurrence DNA double strand...
The effects of radiation on biological systems have been studied for many years, and it is now accepted that direct damage to DNA from the triggering event leading effects. In present study, induced by acute or chronic irradiation was compared at cellular (zebrafish [Danio rerio] cell line ZF4) developmental (embryo) levels. Zebrafish ZF4 cells embryos (at 3 h postfertilization) were exposed within ranges doses (0.3-2 Gy/d) dose rates (0.1-0.75 Gy/d). assessed immunodetection γ-H2AX DNA-PK...
Purpose: Xeroderma Pigmentosum (XP) is a rare, recessive genetic disease associated with photosensitivity, skin cancer proneness, neurological abnormalities and impaired nucleotide excision repair of the UV-induced DNA damage. Less frequently, XP can be sensitivity to ionizing radiation (IR). Here, complete radiobiological characterization was performed on panel fibroblasts derived from XP-group D patients (XPD).Materials methods: Cellular radiosensitivity functionality recognition...
Alzheimer’s disease (AD) is the most common neurodegenerative dementia, for which molecular origins, genetic predisposition and therapeutic approach are still debated. In 1980s, cells from AD patients were reported to be sensitive ionizing radiation. order examine basis of this radiosensitivity, ATM-dependent DNA double-strand breaks (DSB) signaling repair investigated by applying an based on radiation-induced ataxia telangiectasia-mutated (ATM) protein nucleoshuttling (RIANS) model. Early...