A5101933483- Ion Channels and Receptors
- Orthodontics and Dentofacial Orthopedics
- Temporomandibular Joint Disorders
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Skin and Cellular Biology Research
- Ion channel regulation and function
- Peptidase Inhibition and Analysis
- Obstructive Sleep Apnea Research
- Neurobiology and Insect Physiology Research
- dental development and anomalies
- Ion Transport and Channel Regulation
- Erythrocyte Function and Pathophysiology
- Cardiac Fibrosis and Remodeling
- Advancements in Transdermal Drug Delivery
- Biochemical Analysis and Sensing Techniques
- Dental Radiography and Imaging
- Shoulder Injury and Treatment
- Dental Anxiety and Anesthesia Techniques
- Neuroscience of respiration and sleep
- Dermatology and Skin Diseases
- Signaling Pathways in Disease
- Voice and Speech Disorders
- Pain Mechanisms and Treatments
- Tactile and Sensory Interactions
Universidad de Oviedo
2013-2023
Central University Hospital of Asturias
2016-2020
Biogipuzkoa Health Research Institute
2016
Instituto de Investigación Sanitaria del Principado de Asturias
2016
Universidad Autónoma de Chile
2016
Servicio Murciano de Salud
2009
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a point mutation in the LMNA gene that activates cryptic donor splice site and yields truncated form of prelamin A called progerin. Small amounts progerin are also produced during normal aging. Studies with mouse models HGPS have allowed recent development first therapeutic approaches for this disease. However, none these earlier works addressed aberrant pathogenic splicing observed patients because lack an appropriate model. Here, we...
Abstract Decline of tactile sensation associated with ageing depends on modifications in skin and both central peripheral nervous systems. At present, age‐related changes the periphery somatosensory system, particularly concerning effects mechanoreceptors, remain unknown. Here we used immunohistochemistry to analyse age‐dependent Meissner's Pacinian corpuscles as well Merkel cell‐neurite complexes. Moreover, variations neurotrophic TrkB‐ BDNF system mechanoprotein Piezo2 (involved...
Background In adult patients, treatment of skeletal crossbite requires combined by fixed or removable appliances and orthognathic surgery. cases dentoalveolar crossbite, expansion can be achieved with multibrackets transparent aligners. Various researchers have already assessed the Invisalign system’s predictability for arch expansion. However, most this research was conducted using older appliances, making it necessary to assess characteristics updated system SmartTrack. Material methods A...
Statement of problemIntraoral scanners (IOSs) provide a digital alternative to conventional implant impression techniques. However, the effect supramucosal height scan body and angulation on accuracy IOSs remains unclear.PurposeThe purpose this in vitro study was measure impact (trueness precision) intraoral scans partially edentulous models.Material methodsTwo maxillary casts with 4 analogs were fabricated, 1 parallel implants (P-groups) 2 distally inclined 18 degrees (A-groups). An...
The transformation of mechanical energy into electrical signals is the first step in mechanotransduction peripheral sensory nervous system and relies on presence mechanically gated ion channels within specialized organs called mechanoreceptors. Piezo2 a vertebrate stretch-gated channel necessary for mechanosensitive mammalian cells. Functionally, it related to light touch, which has been detected murine cutaneous Merkel cell-neurite complexes, Meissner-like corpuscles lanceolate nerve...
Anti-inflammatory substances used for treatment of pain and discomfort related to orthodontic (OT) could slow down tooth movement. Selective cyclooxygenase-2 inhibitors are an alternative conventional non-steroidal anti-inflammatory drugs. The aim this study was compare different coxibs on dental movement in the rat. Twenty-eight Wistar male rats (3 months old) divided into four experimental groups were studied: (1) Five underwent a 50 g coil spring implantation received three injections 0.5...
Abstract TRPV4 is a nonselective cation channel that belongs to the vanilloid (V) subfamily of transient receptor potential (TRP) ion channels. While TRP channels have been found be involved in sensing temperature, light, pressure, and chemical stimuli, TPRV4 believed primarily mechanosensor although it can also respond warm temperatures, acidic pH, several compounds. In zebrafish, expression trpv4 has studied during embryonic development, whereas its pattern adult life not thoroughly...
Abstract Diverse proteins of the denegerin/epithelial sodium channel (DEG/ENa + C) superfamily, in particular those belonging to acid‐sensing ion (ASIC) family, as well some members transient receptor protein (TRP) channel, function mechanosensors or may be required for mechanosensation a diverse range species and cell types. Therefore, we investigated putative mechanosensitive human odontoblasts using immunohistochemistry detect ENa C subunits (α, β, γ) ASIC (1, 2, 3, 4) proteins, TRPV4,...
ABSTRACT The coordinate neural regulation of the upper airways muscles is basic to control airway size and resistance. superior constrictor pharyngeal muscle (SCPM) forms main part lateral posterior walls pharynx typically devoid spindles, type proprioceptor. Because proprioception arising from SCPM potentially important in physiology airways, we have investigated if there are mechanical sensory nerve endings substitute for spindles. Samples human were analyzed using immunohistochemistry...
Abstract Myelinated nerve fibres forming sensory corpuscles become amyelinic before entering the corpuscle. Interestingly, in Meissner from monkey myelin basic protein (MBP), a specific component of sheath co‐localized with neuronal markers. To investigate whether or not this also occurs human digital corpuscles, we used single and double immunohistochemistry to detect MBP associated axonic (protein gene product (PGP) 9.5) Schwann Schwann‐related cell (S100 protein) We studied these markers...