A5087266867- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Congenital Heart Disease Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Axon Guidance and Neuronal Signaling
- Peptidase Inhibition and Analysis
- Cardiac Valve Diseases and Treatments
- Occupational and environmental lung diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Hereditary Neurological Disorders
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Skin and Cellular Biology Research
- Cellular Mechanics and Interactions
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Histiocytic Disorders and Treatments
- Congenital gastrointestinal and neural anomalies
- Cell Adhesion Molecules Research
Hospital Universitario La Paz
2002-2024
Hospital Universitario Son Espases
2024
Universidad Autónoma de Madrid
2023
Pfizer (Spain)
2021
Hospital La Paz Institute for Health Research
2019-2020
Vall d'Hebron Hospital Universitari
2016
Hospital Universitario Infanta Sofía
2012
Universidad de Oviedo
1995-2009
Instituto de Investigación Sanitaria del Principado de Asturias
2008
Hospital General De Segovia
1978-1999
Major urban pollutants have a considerable influence on the natural history of lung disease. However, this effect is not well known in idiopathic pulmonary fibrosis (IPF).
Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing metabolic adaptation to tumorigenic demands and resistance chemotherapeutics. In this study, we discover that also propels tumorigenesis gliomas glioblastomas inducing the expression of transcriptional co-activator TAZ, protein Hippo signaling pathway promotes growth. The genes encoding (NFE2L2) TAZ (WWTR1) showed positive correlation 721 from...
Introduction Air pollution has a significant impact on the morbidity and mortality of various respiratory diseases. However, this not been widely studied in diffuse interstitial lung diseases, specifically idiopathic pulmonary fibrosis. Objective In study we aimed to assess relationship between four major air pollutants individually [carbon monoxide (CO), nitrogen dioxide (NO 2 ), ozone (O 3 oxides x )] development chronic failure, hospitalization due causes patients with Methods We...
Abstract Myelinated nerve fibres forming sensory corpuscles become amyelinic before entering the corpuscle. Interestingly, in Meissner from monkey myelin basic protein (MBP), a specific component of sheath co‐localized with neuronal markers. To investigate whether or not this also occurs human digital corpuscles, we used single and double immunohistochemistry to detect MBP associated axonic (protein gene product (PGP) 9.5) Schwann Schwann‐related cell (S100 protein) We studied these markers...
Background Trk proteins are essential constituents of the high-affinity signal-transducing neurotrophin receptors. They expressed in a variety non-neuronal tissues, including lymphoid organs, but their cellular localization these remains to be established, as does exact role neurotrophins immune system. In this study we used immunohistochemical methods analyze distribution TrkA, TrkB, TrkC, and p75 (the low-affinity pan-neurotrophin receptor) normal human lymph nodes. Methods...
Increasing evidence suggests that some members of the neurotrophic factor family neurotrophins could be implicated in regulation immune responses. Neurotrophins, as well their tyrosine kinase signal‐transducing receptors (the so‐called Trk neurotrophin receptors), have been detected different lymphoid tissues, although cellular localization is not known. In this study we used single and double immunohistochemistry to localize TrkB situ rat thymus (in animals from 0 days 2 years age),...
Abstract Background The promoter hypermethylation of the methylguanine-DNA methyltransferase gene is a frequently used biomarker in daily clinical practice as it associated with favorable prognosis glioblastoma patients treated temozolamide. Due to absence adequately standardized techniques, international harmonization MGMT methylation still an unmet need for diagnosis and treatment patients. Results In this study we carried out validation quantitative assay detection by comparing novel MSP...
Increasing evidence suggests that, in addition to peripheral sensory and sympathetic neurons, the enteric neurons are also under control of neurotrophins. Recently, neurotrophin receptors have been detected developing adult mammalian nervous system (ENS). Nevertheless, it remains be established whether expressed all and/or glial cells expression is a common feature mammals or if interspecific differences exist. Rabbit polyclonal antibodies against Trk proteins (regarded as essential...
The development of Meissner-like and Pacinian corpuscles was studied in mice [from postnatal day (Pd) 0 to 42] by using immunohistochemistry for specific corpuscular constituents. battery antigens investigated included PGP 9.5 protein neurofilaments, as markers the central axon; S100 protein, vimentin, p75(LNGFR) show Schwann-related cells; epithelial membrane antigen identify perineurial-related cells. In immunoreactivity (IR) neuronal found Pd7 later. lamellar cells these expressed first...
Background Increasing evidence suggests that nerve growth factor (NGF), and probably other neurotrophins, are involved in the control of lymphoid organs immunocompetent cells express neurotrophins and/or their receptors. In rat thymus, mRNA for TrkA (an essential component NGF signal transducing receptor) has been found primarily stromal cells. The present study was undertaken to analyze occurrence localization human using Western blot immunohistochemical techniques. Methods Thymuses from...
Abstract Objective: The aim of this study was to investigate the role matrix metalloproteinase (MMP)‐9 protein in high‐grade malignant tumors salivary gland origin as well its utility a prognostic marker. Methods: Four micrometer sections from 27 neoplasms were immunostained using specific antibody against MMP‐9. staining results (proportion stained tumor cells and intensity stainings) correlated with clinical data patient outcomes. Results: Immunostaining for MMP‐9 observed 17 cases,...
Abstract In addition to their well‐known actions within the nervous system, neurotrophins and receptors are involved in immune system functioning, as demonstrated by wide distribution lymphoid tissues vitro on immunocompetent cells. Nevertheless, vivo roles of neurotrophin‐receptor systems tissues, well scope influence throughout development adulthood, yet be clarified. present study, we used combined morphological immunohistochemical techniques investigate presence cellular localization p75...
Non-small-cell lung cancer (NSCLC) is the most common malignancy worldwide. Platinum-based chemotherapy standard of care for these patients. Recent research showed that miR-7 methylation status a biomarker cisplatin resistance in and ovarian cells, which one major limitations associated with their clinical management. The aim present study to provide insights this novel potential NSCLC patients by comparing treatment response. Our results analyzed 81 samples show event tumor tissue it more...