A5055015267- Genomics, phytochemicals, and oxidative stress
- Hippo pathway signaling and YAP/TAZ
- FOXO transcription factor regulation
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Coenzyme Q10 studies and effects
- MicroRNA in disease regulation
- Calcium signaling and nucleotide metabolism
- Tryptophan and brain disorders
- Cellular Mechanics and Interactions
- Nuclear Receptors and Signaling
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Nitrogen and Sulfur Effects on Brassica
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
Universidad Autónoma de Madrid
2013-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2013-2024
Instituto de Investigaciones Biomédicas Sols-Morreale
2016-2024
Centro de Investigación Biomédica en Red
2020-2024
Instituto de Salud Carlos III
2016-2024
Hospital La Paz Institute for Health Research
2020-2022
Consejo Superior de Investigaciones Científicas
2020
Centro de Biología Molecular Severo Ochoa
2013-2017
Autophagy is a highly coordinated process that controlled at several levels including transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) as regulator of autophagy gene expression and its relevance in mouse model Alzheimer disease (AD) reproduces impaired APP (amyloid β precursor protein) human (Hs)MAPT/TAU processing, clearance aggregation. We screened chromatin immunoprecipitation database ENCODE for proteins, MAFK BACH1,...
Non-alcoholic steatohepatitis (NASH) is a common chronic liver disease that compromises function, for which there not specifically approved medicine. Recent research has identified transcription factor NRF2 as potential therapeutic target. However, current activators, designed to inhibit its repressor KEAP1, exhibit unwanted side effects. Alternatively, we previously introduced PHAR, protein-protein interaction inhibitor of NRF2/β-TrCP, induces mild activation and selectively activates in...
Abstract Many solid tumors contain a subpopulation of cells with stem characteristics and these are known as cancer (CSCs) or tumor-initiating (TICs). These drive tumor growth appear to be regulated by molecular pathway different from other in the bulk. Here, we set out determine whether elements PI3K-AKT necessary maintain CSC-like phenotype breast for survive, bearing mind that identification such is likely relevant define future therapeutic targets. Our results demonstrate close...
Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing metabolic adaptation to tumorigenic demands and resistance chemotherapeutics. In this study, we discover that also propels tumorigenesis gliomas glioblastomas inducing the expression of transcriptional co-activator TAZ, protein Hippo signaling pathway promotes growth. The genes encoding (NFE2L2) TAZ (WWTR1) showed positive correlation 721 from...
Transcription factor NRF2 is a master regulator of the multiple cytoprotective responses that confer growth advantages on cell. However, its participation in mechanisms govern cell division cycle has not been explored detail. In this study, we used several standard methods synchronization proliferating cells together with flow cytometry and monitored along by knockdown gene expression. We found levels were highest at S phase entry, lowest mitosis. depletion promoted both G1 M arrest....
The mechanisms involved in regulation of quiescence, proliferation, and reprogramming Neural Stem Progenitor Cells (NSPCs) the mammalian brain are still poorly defined. Here, we studied role transcriptional co-factor TAZ, regulated by WNT Hippo pathways, homeostasis NSPCs. We found that, murine neurogenic niches striatal subventricular zone dentate gyrus granular zone, TAZ is highly expressed NSPCs declines with ageing. Moreover, expression lost immature neurons both regions. To characterize...
Due to their high metabolic rate, tumor cells produce exacerbated levels of reactive oxygen species that need be under control. Wiskott–Aldrich syndrome protein (WASP)-interacting (WIP) is a scaffold with multiple yet poorly understood functions participates in progression and promotes cancer cell survival. However, its participation the control oxidative stress has not been addressed yet. We show WIP depletion increases reduces transcription factor NRF2, master regulator redox homeostasis....
Resumen del trabajo presentado al 5th Symposium on Biomedical Research: Advances and Perspectives In Pharmacology, Drug Toxicity Pharmacogenetics, celebrado en Madrid 15 16 de marzo 2018.
Transcription factor NRF2 is considered a master regulator of cell homeostasis, coordinating multiple cytoprotective responses that confer growth advantage to cells. Although its implication in redox detoxification or metabolic reprogramming has been widely studied, participation cycle division and the mechanisms governing this process not explored detail. In study, we used several standard methods synchronization proliferating cells G1, before S entry during mitosis. Together with flow...