A5077533093- Circadian rhythm and melatonin
- Free Radicals and Antioxidants
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Glutathione Transferases and Polymorphisms
- Antioxidant Activity and Oxidative Stress
- Coenzyme Q10 studies and effects
- Photoreceptor and optogenetics research
- Cancer, Lipids, and Metabolism
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Metabolism, Diabetes, and Cancer
- Photoacoustic and Ultrasonic Imaging
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Genetics, Aging, and Longevity in Model Organisms
- Stress Responses and Cortisol
- Birth, Development, and Health
- Natural Products and Biological Research
- Redox biology and oxidative stress
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Adipose Tissue and Metabolism
Instituto de Investigación Sanitaria del Principado de Asturias
2016-2025
Universidad de Oviedo
2016-2025
Centre National de la Recherche Scientifique
2024
Center for Cancer Research
2024
National Cancer Institute
2024
Laboratory of Excellence GR-Ex
2024
Institut de Génétique Moléculaire de Montpellier
2024
Université de Montpellier
2024
National Institutes of Health
2024
Instituto de Investigación Biosanitaria de Granada
2021
It is well known that porphyrins cause a toxic light-mediated effect due to their capability generate free radicals. Several reports have proved melatonin potent radical scavenger. The aim of this work has been study the ability prevent cell damage caused by in Harderian gland female Syrian hamsters. Cell injury was evaluated estimating percentage damaged cells found and analyzing degree at ultrastructural level. To explain mechanism which hormone could porphyrins, its both decrease...
Melatonin is a molecule present in multitude of taxa and may be ubiquitous organisms. It has been found bacteria, unicellular eukaryotes, macroalgae, fungi, plants animals. A primary biological function melatonin primitive organisms antioxidant defence to protect against toxic free radical damage. During evolution, adopted by multicellular perform many other functions. These functions likely include the chemical expression darkness vertebrates, environmental tolerance fungi plants, sexual...
Kotler M, Rodríguez C, Sáinz RM, Antolín I, Menéndez‐Peláez A. Melatonin increases gene expression for antioxidant enzymes in rat brain cortex. J. Pineal Res. 1998; 24:83–89. © Munksgaard, Copenhagen Abstract During the last years several reports have demonstrated that melatonin is a efficient free radical scavenger and general antioxidant. In addition, it has been shown this neurohormone able to increase activity of glutathione peroxidase cortex as well some Harderian gland female Syrian...
The biogenic amine N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) was investigated for its potential antioxidative capacity. AFMK is a metabolite generated through either an enzymatic or chemical reaction pathway from melatonin. physiological function of remains unknown. To our knowledge, this report the first to document potent antioxidant action amine. Cyclic voltammetry (CV) shows that donates two electrons at potentials 456 mV and 668 mV, therefore it functions as reductive force. This...
In numerous experimental systems, the neurohormone melatonin has been shown to protect against oxidative stress, an effect which appears be result of a combination different actions. this study, we have investigated possible contribution radical scavenging by substituted kynuramines formed from via pyrrole ring cleavage. N1-Acetyl-5-methoxykynuramine (AMK), metabolite deriving mechanisms involving free radicals, exhibits potent antioxidant properties exceeding those its direct precursor...
Abstract: Melatonin and classic antioxidants possess the capacity to scavenge ABTS ḃ+ with IC 50 s of 4, 11, 15.5, 17 21 μ m for melatonin, glutathione, vitamin C, trolox, NADH NADPH, respectively. In terms scavenging , melatonin exhibits a different profile than that antioxidants. Classic one or less while each molecule can more probably maximum four. do not synergize when combined in . However, synergistic action is observed any Cyclic voltammetry indicates donates an electron at potential...
Abstract Melatonin is present in a multitude of taxa and it has broad range biological functions, from synchronizing circadian rhythms to detoxifying free radicals. Some functions melatonin are mediated by its membrane receptors but others receptor‐independent. For the latter, must enter into cell. derivative amino acid tryptophan reportedly easily crosses membranes due amphipathic nature. However, mechanism which enters cells remains unknown. Changes redox state, endocytosis pathways,...