A5019047604- Erythrocyte Function and Pathophysiology
- Liver physiology and pathology
- Skin and Cellular Biology Research
- Ion channel regulation and function
- Advancements in Transdermal Drug Delivery
- Cellular transport and secretion
- Dermatology and Skin Diseases
- Caveolin-1 and cellular processes
- Polyomavirus and related diseases
- Wnt/β-catenin signaling in development and cancer
- Ion Transport and Channel Regulation
- Gastric Cancer Management and Outcomes
- Neuroscience of respiration and sleep
- Planarian Biology and Electrostimulation
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Neurobiology and Insect Physiology Research
- Corneal surgery and disorders
- Proteoglycans and glycosaminoglycans research
- Tactile and Sensory Interactions
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Hereditary Neurological Disorders
- Genetic and rare skin diseases.
- Ion Channels and Receptors
Complejo Hospitalario de Salamanca
2016-2024
Instituto de Investigación Biomédica de Salamanca
2020-2024
Universidad de Oviedo
2014-2023
Max Planck Institute of Molecular Cell Biology and Genetics
2023
Queen Mary University of London
2023
William Harvey Research Institute
2023
Universidad de Salamanca
2017-2021
Biogipuzkoa Health Research Institute
2016
Central University Hospital of Asturias
2011-2016
Universidad Autónoma de Chile
2016
Abstract Decline of tactile sensation associated with ageing depends on modifications in skin and both central peripheral nervous systems. At present, age‐related changes the periphery somatosensory system, particularly concerning effects mechanoreceptors, remain unknown. Here we used immunohistochemistry to analyse age‐dependent Meissner's Pacinian corpuscles as well Merkel cell‐neurite complexes. Moreover, variations neurotrophic TrkB‐ BDNF system mechanoprotein Piezo2 (involved...
Endothelial barrier dysfunction underlies chronic inflammatory diseases. In searching for new proteins essential to the human endothelial response, we have found that endosomal GTPase RhoB is up-regulated in response cytokines and expressed endothelium of some chronically inflamed tissues. We show although related RhoA RhoC play additive redundant roles various aspects function, specifically inhibits restoration after acute cell contraction by preventing plasma membrane extension. During...
The transformation of mechanical energy into electrical signals is the first step in mechanotransduction peripheral sensory nervous system and relies on presence mechanically gated ion channels within specialized organs called mechanoreceptors. Piezo2 a vertebrate stretch-gated channel necessary for mechanosensitive mammalian cells. Functionally, it related to light touch, which has been detected murine cutaneous Merkel cell-neurite complexes, Meissner-like corpuscles lanceolate nerve...
Abstract Background Resection techniques for small polyps include cold snare polypectomy (CSP) and hot (HSP). This study compared CSP HSP in 5–9 mm terms of complete resection adverse events. Methods was a multicenter, randomized trial conducted seven Spanish centers between February November 2019. Patients with ≥ 1 polyp were to or HSP, regardless morphology pit pattern. After polypectomy, two marginal biopsies submitted pathologist who blinded histology. Complete defined as normal mucosa...
Distal diabetic sensorimotor polyneuropathy (DDSP) is the most prevalent form of neuropathy, and some patients develop gradual pain. Specialized sensory structures present in skin encode different modalities somatosensitivity such as temperature, touch, The cutaneous responsible for qualities mechanosensitivity (fine vibration) are collectively known mechanoreceptors (Meissner corpuscles, Pacinian Merkel cell-axonal complexes), which results altered during diabetes. Here, we used...
Loss of apicobasal polarity is a hallmark epithelial pathologies. Leukocyte infiltration and crosstalk with dysfunctional barriers are crucial for the inflammatory response. Here, we show that architecture regulates adhesion between hepatic cells lymphocytes. Polarized hepatocytes epithelium from bile ducts segregate intercellular molecule 1 (ICAM-1) receptor onto their apical, microvilli-rich membranes, which less accessible by circulating immune cells. Upon cell depolarization, ICAM-1...
Abstract Meissner's corpuscles are the most abundant sensory in glabrous skin of male prepuce. They type I, rapidly adapting, low‐threshold mechanoreceptors, and their function is linked to expression mechanoprotein piezo‐type mechanosensitive ion channel component 2 (PIEZO2). Stimulation genital gives rise sexual sensations. It has been recently demonstrated that digital corpuscles, Meissner‐like end bulbs have an endoneurium‐like capsule surrounding neuronal elements; is, axon glial...
ABSTRACT The coordinate neural regulation of the upper airways muscles is basic to control airway size and resistance. superior constrictor pharyngeal muscle (SCPM) forms main part lateral posterior walls pharynx typically devoid spindles, type proprioceptor. Because proprioception arising from SCPM potentially important in physiology airways, we have investigated if there are mechanical sensory nerve endings substitute for spindles. Samples human were analyzed using immunohistochemistry...
Cervical chondrocutaneous remnants are congenital, benign, and rare neck masses. We present here for the first time immunohistochemical profile of Pacinian corpuscles in cervical remnants, removed, localized territory second branchial arch from a 5-year-old girl. have performed immunohistochemistry to analyze these sensory using battery antibodies including markers each corpuscle constituent. The central axon was immunoreactive neurofilaments, neuron-specific enolase, neural cell adhesion...
Abstract Meissner corpuscles are cutaneous mechanoreceptors that usually located in the dermal papillae of human glabrous skin. Structurally, these sensory consist a mechanoreceptive neuron surrounded by non‐myelinating lamellar Schwann‐like cells. Some authors have described partially developed fibroblastic capsule endoneurial or perineurial origin around corpuscles; however, others noted structures non‐encapsulated. As there is continuity between periaxonic cells forming and nerve trunks,...
Abstract The clitoris is a leading player in female sexual arousal, if not the main protagonist. Despite this role, studies performed on structure with specific neuroanatomical techniques are few. This study focuses glans innervation, special emphasis sensory corpuscles and presence of mechanotransducer protein PIEZO2 these structures. Six samples were obtained at autopsy covering an age spectrum between 52 83 years old. Several types nerve terminations including free endings, genital...
Apical localization of Intercellular Adhesion Receptor (ICAM)-1 regulates the adhesion and guidance leukocytes across polarized epithelial barriers. Here, we investigate molecular mechanisms that determine ICAM-1 into apical membrane domains hepatic cells, their effect on lymphocyte-hepatic cell interaction. We had previously shown segregation domains, which form bile canaliculi ducts in requires basolateral-to-apical transcytosis. Searching for protein machinery potentially involved...
In the last decade a group of Ca2+ channels called Piezo were discovered, demonstrating decisive role in cellular response to mechanical stimuli and being essential biological behaviour cells regarding extracellular compartment. Several investigations have suggested potential carcinogenesis with tumor supressor some cases, but increased expression several high grade neoplasms. Regarding Piezo2 mammary gland neoplasms, early results protective Piezo2, posterior works resulted relationship...
In the last decade, a group of Ca2+ channels called Piezo were discovered, demonstrating decisive role in cellular response to mechanical stimuli and being essential biological behavior cells regarding extracellular compartment. Several investigations have suggested potential carcinogenesis, with tumor suppressor some cases but increased expression several high-grade neoplasms. Regarding Piezo2 mammary gland neoplasms, protective for was initially suggested, subsequent study demonstrated...
Transdermal delivery can be accomplished through various mechanisms including formulation optimization, epidermal stratum corneum barrier disruption, or directly by removing the layer. Microneedling, electroporation, a combination of both and also intradermal injection known as mesotherapy have proved efficacy in epidermal-barrier disruption. Here we analyzed effects these methods disruption structure skin absorption four compounds with different characteristics properties (ketoprofen,...
Abstract Ruffini's corpuscles are present as long fusiform encapsulated sensory structures in different tissues including the skin. Although physiological analyses strongly suggest their existence glabrous digital skin, such localisation remains unconfirmed. Here, we have investigated occurrence of typical 372 sections human skin obtained from 186 subjects both sexes and ages (19–92 years). S100 protein, neuron‐specific enolase neurofilament proteins were detected, basic immunohistochemical...