A5103084988- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Cancer survivorship and care
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Economic and Financial Impacts of Cancer
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Patient Satisfaction in Healthcare
Universidad de Navarra
2012-2025
Universidad Católica del Norte
2025
Navarre Institute of Health Research
2019-2024
Navarrabiomed
2021-2024
Complejo Hospitalario de Navarra
2014-2023
Servicio Navarro de Salud
2021
Hospital Arnau de Vilanova
2009-2010
Hospital Clínico Universitario Lozano Blesa
2010
Hospital Universitario Miguel Servet
2010
Fundación Instituto Valenciano de Oncología
2009
PURPOSE The optimal therapeutic sequence of the adjuvant chemotherapy component preoperative chemoradiotherapy (CRT) for patients with locally advanced rectal cancer is controversial. Induction before CRT may be associated better efficacy and compliance. PATIENTS AND METHODS A total 108 were randomly assigned to arm A-preoperative capecitabine, oxaliplatin, concurrent radiation followed by surgery four cycles postoperative capecitabine oxaliplatin (CAPOX)-or B-induction CAPOX surgery....
PDL1 blockade produces remarkable clinical responses, thought to occur by T cell reactivation through prevention of PDL1-PD1 inhibitory interactions. Here, we find that cell-intrinsic signaling protects cancer cells from interferon (IFN) cytotoxicity and accelerates tumor progression. inhibited IFN signal transduction a conserved class sequence motifs mediate crosstalk with signaling. Abrogation expression or antibody-mediated strongly sensitized STAT3/caspase-7-dependent pathway. Moreover,...
Article6 June 2019Open Access Source DataTransparent process Functional systemic CD4 immunity is required for clinical responses to PD-L1/PD-1 blockade therapy Miren Zuazo Immunomodulation Group, Biomedical Research Center of Navarre-Navarrabiomed, Fundación Miguel Servet, IdISNA, Pamplona, Spain Search more papers by this author Hugo Arasanz Gonzalo Fernández-Hinojal Department Oncology, Hospital Complex Navarre, Maria Jesus García-Granda María Gato Ana Bocanegra Maite Martínez Berta...
PD-L1 tumor expression is a widely used biomarker for patient stratification in PD-L1/PD-1 blockade anticancer therapies, particularly lung cancer. However, the reliability of this marker still under debate. Moreover, expressed by many immune cell types, and little known on relevance systemic PD-L1⁺ cells responses to checkpoint blockade. We present two clinical cases patients with non-small cancer (NSCLC) PD-L1-negative tumors treated atezolizumab that showed either objective or...
Preclinical studies suggest that a vascular endothelial growth factor (VEGF) blockade may play role in the preoperative treatment of rectal adenocarcinoma; however, how to combine anti-VEGF drugs with neoadjuvant chemotherapy (CT) and/or chemoradiotherapy (CRT) remains controversial.To study effect aflibercept plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) induction CT prior standard CRT total mesorectal excision (TME) surgery patients high-risk adenocarcinoma.In Grupo...
Single-agent immunotherapy has been widely accepted as frontline treatment for advanced non-small cell lung cancer (NSCLC) with high tumor PD-L1 expression, but most patients do not respond and the mechanisms of resistance are well known. Several works have highlighted immunosuppressive activities myeloid subpopulations, including low-density neutrophils (LDNs), although context in which these cells play their role is defined. We prospectively monitored LDNs peripheral blood from NSCLC...
Precision medicine in oncology aims to identify the most beneficial interventions based on a patient's individual features and disease. However, disparities exist when providing cancer care patients an individual's sex.To discuss how sex differences impact epidemiology, pathophysiology, clinical manifestations, disease progression, response treatment, with focus data from Spain.Genetic environmental factors (social or economic inequalities, power imbalances, discrimination) that contribute...
Abstract Many cancer patients do not benefit from PD-L1/PD-1 blockade immunotherapies. PD-1 and LAG-3 co-upregulation in T-cells is one of the major mechanisms resistance by establishing a highly dysfunctional state T-cells. To identify shared features associated to PD-1/LAG-3 dysfunctionality human cancers T-cells, multiomic expression profiles were obtained for all TCGA immune infiltrates. A signature was found which regulated immune, metabolic, genetic, epigenetic pathways, but especially...
640 Background: The literature on burden of disease studies hepatocellular carcinoma is scarce. aim this analysis was to quantify the economic recurrence in very early or early-stage HCC patients who underwent liver resection, ablation transplantation Spain. Methods: A decision-tree model developed estimate cost a after curative treatment with an initial complete response primary tumor over 5-year time horizon. Clinical parameters were collected by multidisciplinary group experts also...
Background Despite the evidence of sense coherence (SOC) as a key factor in stress management and health promotion, there is little information about its connection with healthy lifestyles migrant population. Objective To investigate relationship between variables SOC Healthy Lifestyles south-south Study design Non-experimental, cross-sectional correlational study. Method A total 1,844 migrants living Chile participated, selected through non-probabilistic intentional sampling. The lifestyle...
Treatment with nab-paclitaxel plus gemcitabine increases survival in patients metastatic pancreatic cancer. However, the assessment of treatment efficacy and safety non-selected a real-life setting may provide useful information to support decision-making processes routine practice.Retrospective, multicenter study including cancer, who started first-line between December 2013 June 2015 according clinical practice. In addition describing pattern, overall (OS) progression-free (PFS) were...
Abstract Recent studies highlight the importance of baseline functional immunity for immune checkpoint blockade therapies. High‐dimensional systemic profiling is performed in a cohort non‐small‐cell lung cancer patients undergoing PD‐L1/PD‐1 immunotherapy. Responders show high myeloid phenotypic diversity peripheral blood. To quantify it, we define index as potential biomarker response. This parameter correlates with elevated activated monocytic cells and decreased granulocytic phenotypes....
•Incidence of EORC is progressively increasing in Navarra, similar to many countries worldwide.•This evidence indicates an urgent need advance the age for starting population screening programmes.•Disease-free survival and cancer-specific were between LORC patients.•A higher pCR was achieved patients with EORC.•Potential organ preservation strategies may be considered this young population. BackgroundAlthough incidence mortality rates colorectal cancer have decreased during past decades,...
Abstract Objective This study evaluates satisfaction with care (SC) in cancer patients treated at a Spanish day hospital to identify SC determinants and assess the relationship between quality of life. Methods One hundred seventy‐six different tumour sites disease stages completed European Organization for Research Treatment Cancer Quality Life Questionnaire (EORTC QLQ‐C30), Outpatient Satisfaction Care questionnaire chemotherapy (OUT‐PATSAT35 CT), Oberst patients' perception scales, an item...
Colorectal cancer (CRC) is the second leading cause of dead in Spain. About half patients will eventually develop distant metastases. However, as treatment options are expanding, prognosis has steadily improved over last decades. Management advanced CRC should be discussed within an experienced multidisciplinary team to select most appropriate systemic (chemotherapy and targeted agents) integrate surgical or ablative procedures when indicated. Disease site extent, resectability, tumor...
Commentary10 July 2020Open Access Systemic CD4 immunity: A powerful clinical biomarker for PD-L1/PD-1 immunotherapy Miren Zuazo Navarrabiomed-UPNA, IdISNA, Pamplona, Spain Search more papers by this author Hugo Arasanz Complejo Hospitalario de Navarra-IdISNA, Ana Bocanegra Luisa Chocarro Ruth Vera orcid.org/0000-0003-1524-3147 David Escors Corresponding Author [email protected] Hiroshi Kagamu orcid.org/0000-0003-4523-8517 Saitama Medical University International Center, Hidaka, Japan Grazyna...