A5064165178- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- Urban Transport and Accessibility
- Health, Environment, Cognitive Aging
- Energy and Environment Impacts
- Environmental Justice and Health Disparities
- Vehicle emissions and performance
- Wind and Air Flow Studies
- Atmospheric chemistry and aerosols
- Geological and Geochemical Analysis
- Computational Drug Discovery Methods
- Geochemistry and Geologic Mapping
- Vehicle Noise and Vibration Control
- Impact of Light on Environment and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Injury Epidemiology and Prevention
- Trauma and Emergency Care Studies
- Click Chemistry and Applications
- Emergency and Acute Care Studies
- Cancer Risks and Factors
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Analysis
- Radioactivity and Radon Measurements
Inserm
2011-2024
Centre de Recherche en Cancérologie de Marseille
2024
Centre National de la Recherche Scientifique
2019-2024
Institut Paoli-Calmettes
2024
Institut Pprime
2024
Université Grenoble Alpes
2013-2021
Institut pour l'avancée des biosciences
2011-2021
Centre Léon Bérard
2018-2020
Institut de Biosciences et Biotechnologies
2019
Centre International de Recherche sur le Cancer
2018
Errors in address geocodes may affect estimates of the effects air pollution on health.We investigated impact four geocoding techniques association between urban estimated with a fine-scale (10 m × 10 m) dispersion model and lung function adults.We measured forced expiratory volume 1 sec (FEV1) vital capacity (FVC) 354 adult residents Grenoble, France, who were participants two well-characterized studies, Epidemiological Study Genetics Environment Asthma (EGEA) European Community Respiratory...
Outdoor air pollution is a leading environmental cause of death and cancer incidence in humans. We aimed to estimate the fraction lung attributable fine particulate matter (PM2.5) exposure France, secondarily illustrate influence input data spatial resolution information on levels this estimate. The population (PAF) was estimated using nationwide spatially refined chemistry-transport model with 2-km resolution, neighbourhood-scale density data, relative risk from published meta-analysis....
Fine particulate matter (PM2.5) exposure entails large health effects in many urban areas. Public measures aiming at decreasing air pollution are often designed without targeting an explicit benefit. Our objective was to investigate the and economic benefits social inequalities resulting from several scenarios of reduction PM2.5 exposure, order support decisions about policies.In French conurbations Grenoble Lyon (0.4 1.4 million inhabitants, respectively), yearly average estimated on a 10-m...
Breast cancer is the most frequent in women industrialized countries. Lifestyle and environmental factors, particularly endocrine-disrupting pollutants, have been suggested to play a role breast risk. Current epidemiological studies, although not fully consistent, suggest positive association of risk with exposure several International Agency for Research on Cancer Group 1 air-pollutant carcinogens, such as particulate matter, polychlorinated biphenyls (PCB), dioxins, Benzo[a]pyrene (BaP),...
Variations in the activity of emergency dispatch centers are an obstacle to rationalization resource allocation. Many explanatory factors well known, available advance and could predict volume cases. Our objective was develop evaluate performance a predictive model daily call center activity. A retrospective survey conducted on all cases from 2005 2011 large medical (1,296,153 cases). generalized additive calibrated data 2008 (1461 days, development sample) applied prediction days 2009 (1095...
Application of Land Use Regression Modelling to Assess the Spatial Distribution Road Traffic Noise in Three European CitiesAbstract Number:1881 Inmaculada Aguilera, Maria Foraster, Xavier Basagaña, Elisabetta Corradi, Alexandre Deltell, Morelli, Harish C Phuleria, Martina S Ragettli*, Marcela Rivera, Thomasson, Rémy Slama, and Nino Künzli Aguilera Swiss Tropical Public Health Institute, Switzerland, E-mail Address: [email protected] , Foraster Centre for Research Environmental Epidemiology...
Abstract In drug discovery, the successful optimization of an initial hit compound into a lead molecule requires multiple cycles chemical modification. Consequently, there is need to efficiently generate synthesizable libraries navigate space surrounding primary hit. To address this need, we introduce ChemoDOTS, easy-to-use web server for hit-to-lead freely available at https://chemodots.marseille.inserm.fr/. With tool, users enter activated form then choose from automatically detected...
Abstract Microtubule Targeting Agents (MTAs) constitute a vital category of tubulin-binding compounds, deployed across anticancer therapies. Despite the array MTA drugs developed by pharmaceutical entities, quest for novel efficacious molecules continues unabated. We unveil an innovative in vitro screening methodology employing nano differential scanning fluorimetry (nanoDSF), presenting distinct advantages over known assays. This approach not only assesses compound-tubulin binding but also...
Background: Epidemiological studies have suggested adverse affects of atmospheric pollutants on birth outcomes. In most studies, exposure assessment did not consider space-time activity or indoor air pollution levels. Objectives: Our objective was to compare different approaches allowing characterize during pregnancy. A secondary aim quantify the impact cleaning GPS data used assess activity. Methods: We recruited 40 pregnant women living in an urban area and had them carry a one week at...
Background and Aims: This study is part of "Projet Tri-national Trafic, Air, Bruit et Santé" (TRITABS), a tri-national on traffic air pollution, noise cardiovascular health in three European cities: Basel (CH), Girona (ES) Grenoble (FR). As spatial distribution road pollution varies between cities, city-specific analyses are required to disentangle their effects health. paper focuses the modeling particle number concentration (PN) Basel. Methods: 20-minutes measurements PN volume were...
Background and aims: Different techniques of geocoding can lead to important differences in distance between the true geocoded location. To which extent such impact estimates air pollution effects on health outcomes has not been studied. The objective is assess home outdoor lung function using 2 (spatial interpolation versus parcel matching). Methods: FEV1% predicted was assessed 2001-2007 for 393 adults living Grenoble, France, from follow-up Epidemiological study Genetics Environment...
Background: The concerns regarding possible effects of maternal exposure to atmospheric pollutants on pregnancy outcomes warrant effort in assessment. Aims: We review and discuss the advantages limitations various tools considered epidemiology assess air pollution during pregnancy, focusing outdoor models for personalised Methods results: Models based quality monitoring station (AQMS) networks have a poor spatial resolution. Land-use regression (LUR) an improved resolution but classically...
<sec> <title>BACKGROUND</title> Breast cancer is the most frequent in women industrialized countries. Lifestyle and environmental factors, particularly endocrine-disrupting pollutants, have been suggested to play a role breast risk. Current epidemiological studies, although not fully consistent, suggest positive association of risk with exposure several International Agency for Research on Cancer Group 1 air-pollutant carcinogens, such as particulate matter, polychlorinated biphenyls (PCB),...