A5017135008- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Practices
- Economic and Financial Impacts of Cancer
- Advanced Radiotherapy Techniques
- Clinical practice guidelines implementation
- Influenza Virus Research Studies
- Head and Neck Cancer Studies
- Neutropenia and Cancer Infections
- Cancer survivorship and care
- Cancer Genomics and Diagnostics
- Advances in Oncology and Radiotherapy
- Electronic Health Records Systems
- Health, Medicine and Society
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Radiation Dose and Imaging
- Genomics and Rare Diseases
- Occupational and environmental lung diseases
- Chronic Lymphocytic Leukemia Research
- Vaccine Coverage and Hesitancy
- Genetic factors in colorectal cancer
- Prostate Cancer Diagnosis and Treatment
- Air Quality and Health Impacts
- Radiation Therapy and Dosimetry
Université Lumière Lyon 2
2015-2024
Centre Léon Bérard
2015-2024
Université Claude Bernard Lyon 1
2015-2024
Centre National de la Recherche Scientifique
2012-2024
Centre de Recherche en Cancérologie de Lyon
2015-2024
Université Jean Monnet
2024
Groupe d'Analyse et de Théorie Economique Lyon St Etienne
2011-2023
Santé Publique France
2021
Lyon College
2009-2021
CARE Canada
2019
Xerostomia is a major toxic effect associated with intensity-modulated radiotherapy (IMRT) for oropharyngeal cancers.
Although the management of sarcoma is improving, non adherence to clinical practice guidelines (CPGs) remains high, mainly because low incidence disease and variety histological subtypes. Since little known about health economics sarcoma, we undertook a cost-effectiveness analysis (within CONnective TIssue CAncer NETwork, CONTICANET) comparing costs outcomes when clinicians adhered CPGs they did not. Patients studied had diagnosis were older than 15 years, been treated in Rhône-Alpes region...
Objective This study examined the types of discordance occurring in diagnosis soft tissue and visceral sarcomas, gastrointestinal stromal tumors (GIST), desmoid tumors, as well economic impact diagnostic discrepancies. Methods We carried out a retrospective, multicenter analysis using prospectively implemented databases performed on cohort patients within French RRePS network 2010. Diagnoses were deemed to be discordant based 2013 World Health Organization (WHO) classification. Predictive...
PurposeThis cost analysis aimed to quantify the of IGRT in relation frequency and modality with Cone Beam Computed Tomography (CBCT) or orthogonal electronic portal imaging fiducial markers (EPI-FM).Material methodsPatients undergoing for localized prostate cancer were randomized into two control frequencies (daily weekly). Costs calculated based on micro-costing results according hospitals' perspectives (in Euros, 2009) time horizon was radiation therapy.ResultsA total 208 patients enrolled...
Abstract Background Stereotactic Body Radiation Therapy (SBRT) is an innovative modality based on high precision planning and delivery. Cancer with bone metastases oligometastases are associated intermediate or good prognosis. We assume that prolonged survival rates would be achieved if both the primary tumor controlled by local treatment. Our purpose to demonstrate, via a multicenter randomized phase III trial, treatment of metastatic sites curative intent SBRT systemic standard care...
We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore decrease xerostomia, when compared standard IMRT. conducted ARTIX trial, randomized, parallel-group, multicentric study systematic replanning ART The primary endpoint was frequency of xerostomia at 12 months, measured by stimulating salivary flow with paraffin. CEA designed...
PurposeThe Advanced Radiotherapy Oto-Rhino-Laryngologie (ART-ORL) study (NCT02024035) was performed to prospectively evaluate the clinical and economic aspects of helical TomoTherapy volumetric modulated arc therapy (RapidArc, Varian Medical Systems, Palo Alto, CA) for patients with head neck cancer.Methods MaterialsFourteen centers participated in this prospective comparative study. Randomization not possible based on availability equipment. Patients epidermoid or undifferentiated...
Untreated obstructive sleep apnea-hypopnea syndrome (OSAHS) is associated with excessive daytime sleepiness, increased risk of cardiovascular (CV) disease, and road traffic accidents (RTAs), which impact survival health-related quality life. This study, funded by the French National Authority for Health (HAS), aimed to assess cost-effectiveness different treatments (i.e., continuous positive airway pressure [CPAP], dental devices, lifestyle advice, no treatment) in patients mild-to-moderate...
The glucuronidation of the AT1 nonpeptide angiotensin II receptor antagonist, SR 47436 (BMS 186295), was investigated in hepatic microsomes prepared from various species, i.e., Sprague-Dawley rat, Cynomolgus monkey and Caucasian humans. drug found to undergo N-glucuronidation on tetrazole moiety as confirmed by its hydrolysis beta-glucuronidase, associated radioactivity when UDP-[U-14C]glucuronic acid used substrate different techniques such high-performance liquid chromatography-mass...
In France, 2–15% of the population is affected annually by influenza, which causes significant socioeconomic disruption. Nevertheless, despite its importance for policy makers, few published studies have evaluated impact influenza B. Therefore, we assessed costs associated with B during 2010–2011 in France. Cases lab-confirmed were analyzed as part Influenza General Practice Study. Cost calculations based on micro-costing methods according to French Health Insurance (FHI) perspective (in...
Breast cancer is the most frequent in women industrialized countries. Lifestyle and environmental factors, particularly endocrine-disrupting pollutants, have been suggested to play a role breast risk. Current epidemiological studies, although not fully consistent, suggest positive association of risk with exposure several International Agency for Research on Cancer Group 1 air-pollutant carcinogens, such as particulate matter, polychlorinated biphenyls (PCB), dioxins, Benzo[a]pyrene (BaP),...
Background: There is no evidence to support surgery or radiotherapy as the best treatment for resectable oropharyngeal cancers with a negative HPV status. Predictive algorithms may help decide which strategy choose, but they will only be accepted by caregivers and European authorities if are interpretable. As proof of concept, we developed predictive interpretable algorithm predict locoregional relapse at 18 months first step towards that goal. Methods: The model was based on clinical...
Metabolism and disposition of irbesartan, an angiotensin II AT(1) receptor antagonist, were investigated in mice, rats, rabbits, macaques. In both rats macaques, irbesartan was characterized by a rapid oral absorption, large volume distribution, low plasma clearance, long terminal half-life. The bioavailability macaques notably higher than rats. Irbesartan highly protein bound A lower binding rate found mice rabbits. distribution studies performed rapidly distributed into most organs tissues...