Francesca Romana Mancini
A5068098615- Nutritional Studies and Diet
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Consumer Attitudes and Food Labeling
- Cancer-related Molecular Pathways
- Cancer Risks and Factors
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Obesity, Physical Activity, Diet
- Nutrition, Genetics, and Disease
- Per- and polyfluoroalkyl substances research
- RNA modifications and cancer
- Tea Polyphenols and Effects
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- Air Quality Monitoring and Forecasting
- Phytochemicals and Antioxidant Activities
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
Inserm
2016-2025
Centre de recherche en Epidémiologie et Santé des Populations
2016-2025
Université de Versailles Saint-Quentin-en-Yvelines
2017-2025
Université Paris-Saclay
2017-2025
Institut Gustave Roussy
2017-2024
Sapienza University of Rome
1992-2024
Politecnico di Milano
2022-2024
Institut de Recherche en Santé, Environnement et Travail
2024
University of Florence
2021-2024
Centre International de Recherche sur le Cancer
2023
Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk unknown and has been understudied in European populations to date.
Two isomeric series of dual binding site acetylcholinesterase (AChE) inhibitors have been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase, AChE-induced self-induced β-amyloid (Aβ) aggregation, β-secretase (BACE-1) cross blood−brain barrier. The new hybrids consist a unit 6-chlorotacrine multicomponent reaction-derived pyrano[3,2-c]quinoline scaffold as the active-site peripheral-site interacting moieties, respectively, connected through an...
Abstract Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices complement body mass index (BMI) when assessing all-cause mortality. used data from 352,985 participants in European Prospective Investigation into Cancer Nutrition (EPIC) Cox proportional hazards models adjusted for other risk factors. During a mean follow-up 16.1 years, 38,178 died....
Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications development diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer Nutrition (EPIC) cohort investigate association between circulating levels...
OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal uncertain. To investigate this, we studied the of genetically predicted diabetes. RESEARCH DESIGN AND METHODS We conducted genome-wide studies among 52,018 individuals European ancestry to discover novel genetic variants. performed Mendelian randomization analyses estimate differences in up 80,983 case participants and 842,909 noncase participants. compared...
Abstract Background Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and cancer risk in humans. Methods Associations between prediagnostic plasma of 17 primary, secondary, tertiary metabolites (conjugated unconjugated) were evaluated a nested case-control study within the European Prospective Investigation into Cancer Nutrition (EPIC) cohort. quantified by tandem mass spectrometry samples from 569...
BackgroundUnhealthy diets, the rise of non-communicable diseases, and declining health planet are highly intertwined, where food production consumption major drivers increases in greenhouse gas emissions, substantial land use, adverse such as cancer mortality. To assess potential co-benefits from shifting to more sustainable we aimed investigate associations dietary emissions use with all-cause cause-specific mortality incidence rates.MethodsUsing data 443 991 participants European...
In 2016, the EFSA Panel on Contaminants in Food Chain (CONTAM) published a scientific opinion acute health risks related to presence of cyanogenic glycosides (CNGs) raw apricot kernels which an reference dose (ARfD) 20 μg/kg body weight (bw) was established for cyanide (CN). present opinion, CONTAM concluded that this ARfD is applicable effects CN regardless dietary source. To account differences bioavailability after ingestion certain food items, specific factors were used. Estimated mean...
Endocrine‐disrupting chemicals are proposed to increase breast cancer (BC) incidence. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), two perfluorinated alkylated substances (PFASs), suspected be ubiquitously present in the blood of human population worldwide. We investigated associations between serum concentrations these BC risk. Etude Epidémiologique auprès de femmes l'Education Nationale is a cohort 98,995 French women born 1925–1950 followed up since 1990. sampled...
Abstract Objective To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades nutritional quality of food products and is used to derive Nutri-Score front-of-packet label guide consumers towards healthier choices, associated with mortality. Design Population based cohort study. Setting European Prospective Investigation into Cancer Nutrition (EPIC) from 23 centres in 10 countries. Participants 521 324 adults; at recruitment, country specific validated...
Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence the long-term effect ambient air BaP on breast cancer (BC) limited. Thus we evaluated associations between exposure risk BC, overall according to menopausal status molecular subtypes (estrogen receptor negative/positive (ER−/ER+) progesterone (PR−/PR+)), stage grade...
Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations HCC is derived mostly from case-control designs, with sparse information prospective cohorts. Our objective was to apply comprehensive metabolite profiling detect metabolites whose serum concentrations are associated development, using biological samples within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where...
Abstract Background Perturbations in circulating metabolites prior to a breast cancer diagnosis are not well characterised. We aimed gain more detailed knowledge help understand and prevent the disease. Methods Baseline plasma samples from 791 cases matched controls E3N (EPIC-France) cohort were profiled by nuclear magnetic resonance (NMR)-based untargeted metabolomics. Partial least-squares discriminant analysis (PLS-DA) models built NMR profiles predict disease outcome, odds ratios false...
Nitrogen dioxide (NO2) is an important air pollutant due to its adverse effects on human health. Yet, current evidence the association between NO2 and risk of breast cancer lacks consistency. In this study, we investigated long-term exposure in French E3N cohort study. Association with was assessed a nested case-control study within including 5222 cases identified over 1990-2011 follow-up period matched controls. Annual mean concentrations at participants' residential addresses for each year...
Energy conservation techniques for sensor networks typically rely on the assumption that data sensing and processing consume considerable less energy than communication. This does not hold in some practical application scenarios, where ad hoc developed units require power consumption comparable with, or even larger than, of radio. In this paper we focus an embedded monitoring snow composition mountain slopes avalanche forecasting. To lower propose adaptive sampling algorithm able to...
Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum infertile fertile men from metropolitan, urban rural Italian areas. PFOS PFOA also evaluated seminal plasma. In peripheral blood mononuclear cells (PBMCs) same subjects, gene expression a panel nuclear receptors (NRs), namely estrogen receptor α...