A5015152982- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Peroxisome Proliferator-Activated Receptors
- NF-κB Signaling Pathways
- Environmental Toxicology and Ecotoxicology
- Birth, Development, and Health
- Immune Response and Inflammation
- Bone health and treatments
- Adipose Tissue and Metabolism
- Marine Biology and Environmental Chemistry
- Estrogen and related hormone effects
- Carcinogens and Genotoxicity Assessment
- Cell death mechanisms and regulation
- Pharmacogenetics and Drug Metabolism
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Air Quality and Health Impacts
- Eicosanoids and Hypertension Pharmacology
- Immunotherapy and Immune Responses
- Fatty Acid Research and Health
- Retinoids in leukemia and cellular processes
- Health, Environment, Cognitive Aging
Boston University
2016-2025
Centre International de Recherche sur le Cancer
2023
Public Health Department
2019
Environmental Protection Agency
2019
Oak Ridge Institute for Science and Education
2019
Northeastern University
2014
Woods Hole Oceanographic Institution
1998-2014
Wake Forest University
2014
Yokohama City University
2005
Boston Public Schools
2002
Recent experimental models and epidemiological studies suggest that specific environmental contaminants (ECs) contribute to the initiation pathology of non-alcoholic fatty liver disease (NAFLD). However, underlying mechanisms linking EC exposure with NAFLD remain poorly understood there is no data on their impact human metabolome. Herein, we hypothesized ECs, particularly perfluorinated alkyl substances (PFAS), impacts metabolism, specifically bile acid metabolism.In a well-characterized...
Background: The use of alternative flame retardants has increased since the phase out pentabromodiphenyl ethers (pentaBDEs). One alternative, Firemaster® 550 (FM550), induces obesity in rats. Triphenyl phosphate (TPP), a component FM550, structure similar to that organotins, which are obesogenic rodents.Objectives: We tested hypothesis components FM550 biologically active peroxisome proliferator-activated receptor γ (PPARγ) ligands and estimated indoor exposure TPP.Methods: its were assessed...
Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and risk have garnered most headlines strong, but less attention has been paid other omnipresent toxicants in our ecosystem. Perfluoroalkyl polyfluoroalkyl substances (PFASs) man-made chemicals extensively used industrial consumer products worldwide aqueous film-forming foam utilized...
Environmental toxicants (ETs) are associated with adverse health outcomes. Here we hypothesized that exposures to ETs linked obesity and insulin resistance partly through a dysbiotic gut microbiota changes in the serum levels of secondary bile acids (BAs). Serum BAs, per- polyfluoroalkyl substances (PFAS) additional twenty-seven were measured by mass spectrometry 264 Danes (121 men 143 women, aged 56.6 ± 7.3 years, BMI 29.7 6.0 kg/m
Microsomal cytochrome P-450 1A (CYP1A) in a vertebrate model (the teleost fish scup) is inactivated by the aryl hydrocarbon receptor agonist 3,3′,4,4′-tetrachlorobiphenyl (TCB). Here, mechanism of CYP1A inactivation and its relationship to reactive oxygen species (ROS) formation were examined using liver microsomes from scup rat expressed human CYP1As. In vitro activity 7-ethoxyresorufin <i>O-</i>deethylation TCB was time dependent, NADPH irreversible. increased microsomal oxidation rates,...
The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array of biological processes. Recently, the AHR was shown control host immunity by affecting balance between inflammatory T cells that produce IL-17 (Th17) IL-22 versus regulatory (Treg) tolerance. While ligands can mediate this effect, endogenous are likely be more relevant immune responses. We investigated downstream metabolites tryptophan...
Adverse lung outcomes from exposure to per-and polyfluoroalkyl substances (PFAS) are known; however, the mechanism of action is poorly understood. To explore this, human bronchial epithelial cells were grown and exposed varied concentrations short-chain (perfluorobutanoic acid, perflurobutane sulfonic acid GenX) or long-chain (PFOA perfluorooctane (PFOS)) PFAS, alone in a mixture identify cytotoxic concentrations. Non-cytotoxic PFAS this experiment selected assess NLRP3 inflammasome...
Background: Bis-(2-ethylhexyl) tetrabromophthalate (TBPH) is widely used as a replacement for polybrominated diphenyl ethers (PBDEs) in commercial flame retardant mixtures such Firemaster 550. It also mixture called DP 45. Mono-(2-ethyhexyl) (TBMEHP) potentially toxic metabolite.Objectives: We vitro and rodent vivo models to evaluate human exposure the potential metabolism toxicity of TBPH.Methods: Dust collected from homes, offices, cars was measured TBPH by gas chromatography followed mass...
We have postulated that the aryl hydrocarbon receptor (AHR) drives later, more lethal stages of some cancers when chronically activated by endogenous ligands. However, other studies suggested that, under circumstances, AHR can oppose tumor aggression. Resolving this apparent contradiction is critical to design AHR-targeted cancer therapeutics. Molecular (siRNA, shRNA, repressor, CRISPR-Cas9) and pharmacological (AHR inhibitors) approaches were used confirm hypothesis inhibition reduces human...
Adipocyte differentiation in bone marrow is potentially deleterious to both integrity and lymphopoiesis. Here, we examine the hypothesis that organotins, common environmental contaminants are dual ligands for peroxisome proliferator–activated receptor (PPAR) γ its heterodimerization partner retinoid X (RXR), potent activators of adipogenesis. A C57Bl/6-derived multipotent mesenchymal stromal cell (MSC) line, BMS2, was treated with rosiglitazone, a PPARγ agonist, bexarotene, an RXR or series...
Background:Diabetes and obesity are major threats to public health in the United States abroad. Understanding role that chemicals our environment play development of these conditions is an emerging issue environmental health, although identifying prioritizing for testing beyond those already implicated literature challenging. This review intended help researchers generate hypotheses about may contribute diabetes obesity-related outcomes by summarizing relevant findings from U.S....
Abstract The potential for chemical exposures to exacerbate the development and/or prevalence of metabolic disorders, such as obesity, is currently great societal concern. Various in vitro assays are available assess adipocyte differentiation, though little work has been done standardize protocols and compare models effectively. This study compares several adipogenic cell culture systems under a variety conditions variability responses. Two sources 3T3-L1 preadipocytes well OP9 were assessed...
Organotins are members of the environmental obesogen class contaminants because they activate peroxisome proliferator-activated receptor γ (PPARγ), essential regulator adipogenesis. Exposure to thiazolidinediones (PPARγ ligands used treat type 2 diabetes) is associated with increased fractures. Diminished bone quality likely results from PPARγ's role in promoting adipogenesis while suppressing osteogenesis marrow multipotent mesenchymal stromal cells (BM-MSC). We hypothesized that...