A5078623365- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Nitric Oxide and Endothelin Effects
- Cerebrovascular and Carotid Artery Diseases
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Function and Risk Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vitamin C and Antioxidants Research
- Peripheral Artery Disease Management
- Wnt/β-catenin signaling in development and cancer
- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Diet and metabolism studies
- Lipid metabolism and disorders
- Bariatric Surgery and Outcomes
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Pharmacology and Obesity Treatment
- Lymphatic System and Diseases
- Cardiac Fibrosis and Remodeling
Boston University
2014-2024
Boston Medical Center
1996-2021
University of Yamanashi
2019
University of Shizuoka
2019
Keio University
2019
Nagoya University
2016
Alzheimer’s Disease Neuroimaging Initiative
2015
Brigham and Women's Hospital
2015
University of Michigan
2015
Pfizer (United States)
2015
Background — Brachial artery endothelial function is impaired in individuals with atherosclerosis and coronary risk factors improves reduction therapy. However, the predictive value of brachial dysfunction for future cardiovascular events unknown. Methods Results We preoperatively examined vasodilation using ultrasound 187 patients undergoing vascular surgery. Patients were prospectively followed 30 days after Forty-five had a postoperative event, including cardiac death (3), myocardial...
Background — Epidemiological studies suggest that tea consumption decreases cardiovascular risk, but the mechanisms of benefit remain undefined. Endothelial dysfunction has been associated with coronary artery disease and increased oxidative stress. Some antioxidants have shown to reverse endothelial dysfunction, contains antioxidant flavonoids. Methods Results To test hypothesis will we randomized 66 patients proven consume black water in a crossover design. Short-term effects were examined...
Adipose tissue secretes proteins referred to as adipokines, many of which promote inflammation and disrupt glucose homeostasis. Here we show that secreted frizzled-related protein 5 (Sfrp5), a previously linked the Wnt signaling pathway, is an anti-inflammatory adipokine whose expression perturbed in models obesity type 2 diabetes. Sfrp5-deficient mice fed high-calorie diet developed severe intolerance hepatic steatosis, their adipose showed accumulation activated macrophages was associated...
Formation of nitric oxide-derived oxidants may serve as a mechanism linking inflammation to development atherosclerosis. Nitrotyrosine, specific marker for protein modification by oxidants, is enriched in human atherosclerotic lesions and low-density lipoprotein (LDL) recovered from atheroma.To determine whether systemic levels nitrotyrosine are associated with the prevalence coronary artery disease (CAD) modulated hydroxymethylglutaryl coenzyme-A reductase inhibitor (statin) therapy.A...
Objectives— Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis has been linked insulin resistance. Methods Results— We measured sensitivity by glucose tolerance test vascular function ultrasound venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline during 5 days bed rest. Bed rest led a 67% increase response loading ( P <0.001) suggesting increased resistance produced total...
Background —Loss of endothelium-derived nitric oxide (EDNO) contributes to the clinical expression coronary artery disease (CAD). Increased oxidative stress has been linked impaired endothelial vasomotor function in atherosclerosis, and recent studies demonstrated that short-term ascorbic acid treatment improves function. Methods Results —In a randomized, double-blind, placebo-controlled study, we examined effects single-dose (2 g PO) long-term (500 mg/d) on EDNO-dependent flow-mediated...
Objective— Experimental studies suggest that adipose inflammation is etiologically linked to obesity-induced systemic disease. Our goal was characterize the state of in human fat relation vascular function and metabolic parameters obese individuals. Methods Results— We collected subcutaneous abdominal 77 subjects (BMI ≥30 kg/m 2 ) quantified macrophage population using targeted immunohistochemistry. Brachial artery vasodilator examined high-resolution ultrasound. In 50 subjects, an inflamed...
In vitro and animal studies demonstrate that myeloperoxidase catalytically consumes nitric oxide as a substrate, limiting its bioavailability function. We therefore hypothesized circulating levels of would predict risk endothelial dysfunction in human subjects.Serum was measured by enzyme-linked immunoassay, brachial artery flow-mediated dilation nitroglycerin-mediated were determined ultrasound hospital-based population 298 subjects participating an ongoing study the clinical correlates...
Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and risk have garnered most headlines strong, but less attention has been paid other omnipresent toxicants in our ecosystem. Perfluoroalkyl polyfluoroalkyl substances (PFASs) man-made chemicals extensively used industrial consumer products worldwide aqueous film-forming foam utilized...
The purpose of this study was to determine whether periodontal disease is associated with endothelial dysfunction and systemic inflammation. Epidemiological studies suggest that severe increased cardiovascular risk, but the mechanisms remain unknown.We assessed flow-mediated dilation nitroglycerin-mediated brachial artery using vascular ultrasound in 26 subjects advanced 29 control subjects. groups were matched for age sex, patients hypercholesterolemia, diabetes mellitus, hypertension,...
Some epidemiological studies have shown that increased iron stores are associated with cardiovascular events. Redox-active may contribute to lipid peroxidation, endothelial cell activation, and generation of reactive oxygen species (especially hydroxyl radical, via Fenton chemistry). Increased oxidative stress is impaired action endothelium-derived nitric oxide in patients atherosclerosis.To test the hypothesis reducing vascular would reverse dysfunction, we examined effects chelator...
Reactive hyperemia is the compensatory increase in blood flow that occurs after a period of tissue ischemia, and this response blunted patients with cardiovascular risk factors. The predictive value reactive for events atherosclerosis relative importance compared other measures vascular function have not been previously studied.We prospectively measured brachial artery flow-mediated dilation by ultrasound 267 peripheral arterial disease referred surgery (age 66+/-11 years, 26% female)....
Inflammatory activity in fat tissue has recently been implicated mechanisms of insulin resistance and obesity-related metabolic dysfunction. Toll-like receptors (TLRs) play a key role innate immune responses recent studies implicate the TLR pathway inflammation atherosclerosis. The aim this study was to examine differential expression function human adipose tissue.We biopsied subcutaneous abdominal from 16 obese subjects (age 39+/-11 years, BMI 49+/-14 kg/m2) characterized using quantitative...
We previously reported that adenosine monophosphate-activated protein kinase (AMPK) activity is lower in adipose tissue of morbidly obese individuals who are insulin resistant than comparably people sensitive. However, the number patients and parameters studied were small. Here, we compared abdominal subcutaneous, epiploic, omental fat from 16 classified as sensitive or based on homeostatic model assessment resistance. confirmed AMPK diminished group. A custom PCR array revealed increases...
Abnormal endothelial function promotes atherosclerotic vascular disease in diabetes. Experimental studies indicate that disruption of insulin signaling, through the activity protein kinase C-β (PKCβ) and nuclear factor κB, reduces nitric oxide availability. We sought to establish whether similar mechanisms operate endothelium human diabetes mellitus.We measured expression response freshly isolated cells from patients with type 2 mellitus (n=40) nondiabetic controls (n=36). Unexpectedly, we...
Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance obese individuals. Cell culture studies and gain-of-function mouse models suggest that canonical Wnt proteins modulate adipose expansion. However, no genetic evidence supports for endogenous dysfunction, noncanonical signaling remains largely unexplored. Here we provide from human, mouse, cell showing Wnt5a-mediated, contributes to obesity-associated metabolic by increasing inflammation. Wnt5a expression...