A5101828863- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Liver physiology and pathology
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Macrophage Migration Inhibitory Factor
- NF-κB Signaling Pathways
- Aquaculture disease management and microbiota
- Toxic Organic Pollutants Impact
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Protein Kinase Regulation and GTPase Signaling
- Radiopharmaceutical Chemistry and Applications
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Aquaculture Nutrition and Growth
- T-cell and B-cell Immunology
- Carcinogens and Genotoxicity Assessment
- Cytokine Signaling Pathways and Interactions
- Chemical Reactions and Isotopes
Boston University
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Shantou University
2021-2023
Tianjin Medical University
2022
Second Hospital of Tianjin Medical University
2022
Huazhong University of Science and Technology
2016-2019
Peking Union Medical College Hospital
2019
Tufts University
2016
Shenyang Pharmaceutical University
2016
Boston Medical Center
2010
The endogenous ligand-activated aryl hydrocarbon receptor (AHR) plays an important role in numerous biologic processes. As the known number of AHR-mediated processes grows, so too does importance determining what AHR ligands are produced, how their production is regulated, and consequences ensue. Consequently, our studies were designed primarily to determine whether ER<sup>−</sup>/PR<sup>−</sup>/Her2<sup>−</sup> breast cancer cells have potential produce and, if so, these controlled. We...
Self-renewing, chemoresistant breast cancer stem cells are believed to contribute significantly invasion, migration and patient relapse. Therefore, the identification of signaling pathways that regulate acquisition stem-like qualities is an important step towards understanding why patients relapse development novel therapeutics specifically target cell vulnerabilities. Recent studies identified a role for aryl hydrocarbon receptor (AHR), environmental carcinogen implicated in initiation,...
While immunotherapy has shown some efficacy in lung adenocarcinoma (LUAD) patients, many respond only partially or not at all. One limitation improving outcomes is the lack of a complete understanding immune checkpoint regulation. Here, we investigated possible link between an environmental chemical receptor implicated cancer and regulation, AhR, known but counterintuitive mediator immunosuppression (interferon (IFN)-γ), regulation two checkpoints (PD-L1 IDO). AhR gene-edited LUAD cell...
Over 45,000 new cases of oral and pharyngeal cancers are diagnosed account for over 8,000 deaths a year in the United States. An environmental chemical receptor, aryl hydrocarbon receptor (AhR), has previously been implicated squamous cell carcinoma (OSCC) initiation as well normal tissue-specific stem self-renewal. These previous studies inspired hypothesis that AhR plays role both acquisition progression OSCC, formation maintenance cancer stem-like cells. To test this hypothesis, activity...
The aim of the present study was to evaluate expression levels aryl hydrocarbon receptor (AHR) and its target gene CYP1B1 correlate their with Wnt5a/b-β-catenin, CD44+/CD24(-/low) cancer stem cell (CSC) subset factors associated poor prognosis in inflammatory breast (IBC) non-IBC patients. methods analysis used were quantitative real-time PCR, western blotting, immunohistochemistry flow cytometry. Compared tissues, IBC tissues exhibited overexpression AHR gene/protein CYP1B1. mRNA clinical...
We have postulated that the aryl hydrocarbon receptor (AHR) drives later, more lethal stages of some cancers when chronically activated by endogenous ligands. However, other studies suggested that, under circumstances, AHR can oppose tumor aggression. Resolving this apparent contradiction is critical to design AHR-targeted cancer therapeutics. Molecular (siRNA, shRNA, repressor, CRISPR-Cas9) and pharmacological (AHR inhibitors) approaches were used confirm hypothesis inhibition reduces human...
Significance Immune checkpoint inhibitors have emerged as critical therapeutics for several cancer types, including head and neck squamous cell carcinoma. However, enthusiasm remains constrained by the fact that only a minority of patients benefit. Therefore, there is need to identify new immunotherapy targets. Here, we provide evidence supporting our hypothesis aryl hydrocarbon receptor (AhR) influences multiple immune checkpoints in model oral carcinoma (OSCC). Remarkably, transplant...
Rationale: Nanomaterials capable of specifically interacting with proteins are very important for protein storage and vaccine delivery. Supramolecular hydrogels based on peptides have emerged as promising adjuvants because their good compatibility, ease antigen incorporation display, efficiency in activating immune responses. Methods: We synthesized a self-assembling peptide (Fbp-GDFDFDYDK(γE)2-NH2, Comp. 1 ) serving supramolecular chaperone The gelation was triggered by simply mixing...
Abstract Induced pluripotent stem cells (iPSCs) stand to revolutionize the way we study human development, model disease, and eventually, treat patients. However, these cell sources produce progeny that retain embryonic and/or fetal characteristics. The failure mature definitive, adult-type is a major barrier for iPSC-based disease modeling drug discovery. To directly address concerns, have developed chemically defined, serum feeder-free–directed differentiation platform generate...
In inflammatory bowel diseases (IBD), high mobility group box 1 (HMGB1), as an endogenous molecule, can promote cytokines secretion by acting on TLR2/4 resulting in tissue damage. The underlying mechanisms remain unclear. Here we report a novel role of HMGB1 controlling the maintenance and function intestine-resident group-3 innate lymphoid cells (ILC3s) that are important effector implicated mucosal homeostasis IBD pathogenesis. We showed mice treated with anti-HMGB1 Ab, or genetically...
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor with important functions in the immune response and cancer. AHR agonists are provided by environment, commensal flora metabolism. Considering physiological functions, may have effects on health disease. Thus, quantification of biological samples scientific clinical relevance. We compared different reporter systems for detection serum Multiple Sclerosis (MS) patients, assessed influence transfection methods cell...
Hepatocyte nuclear factor 4α (HNF4α), a liver-specific transcription factor, plays significant role in functions. However, its functions are poorly understood the regulation of inflammatory response. In order to obtain genomic view HNF4α this context, microarray analysis was used probe expression profile an response induced by cytokine stimulation model knock-down HepG2 cells.The over five thousand genes cells is significantly changed with dramatic reduction concentration compared native...
Previously, we have demonstrated that IL-33 administration protecting TNBS-induced experimental colitis is associated with facilitation of Th2/Tregs responses in mice. However, whether regulates autophagy to ameliorate unclear. (2 μg/day, intraperitoneal injection), while facilitating responses, also enhances the mice as well macrophages. In meantime, observed inhibition 3-methyladenine (3-MA) (24 mg/kg, injection) exacerbates colitis. On contrary, rapamycin mg/kg,intragastric...
Abstract Most host organisms undergo metabolic changes in response to pathogens, environmental cues or simply boost their immunity. Metabolic modulation has therefore been exploited by both and pathogens outwit the other during host–pathogen interactions. Recent studies have revealed that a growing number of metabolites processes crustaceans are crucial Here, we reviewed recent work on immune reprogramming takes place induced as strategy withstand these clear pathogen. In aquaculture...
HNF-4α (hepatocyte nuclear factor-4α) is a key regulator of liver-specific gene expression. To understand the mechanisms governing regulation function during APR (acute-phase response), effects transcription co-activators, including p300, PGC-1α (peroxisome-proliferator-activated receptor-γ co-activator-1α) and SRC (steroid receptor co-activator)-1α were investigated in an injury cell model. We have shown previously that HNF-4α-sensitive genes ApoB (apolipoprotein B), TTR (transthyretin)...
Transthyretin is a negative acute phase protein whose serum level decreases during the response. gene expression in liver regulated at transcriptional level, and controlled by hepatocyte nuclear factor (HNF)‐4α other HNFs. The site‐directed mutagenesis of HNF‐4, HNF‐1, HNF‐3 HNF‐6 binding sites transthyretin proximal promoter dramatically activity. Interestingly, mutation HNF‐4 site not only abolishes response to HNF‐4α, but also reduces significantly However, merely affects specific HNFs,...
Abstract —The expression of inducible nitric oxide synthase (iNOS) is a characteristic response to inflammation and can be inhibited with sodium salicylate. We used the cytokine-induced iNOS induction in cardiac fibroblasts as model system which test hypothesis that effects on mitogen-activated protein kinases (MAPKs) may explain mechanism by salicylate exerts its anti-inflammatory effects. Tumor necrosis factor-α (TNF-α) alone induce extracellular signal-regulated kinase (ERK), p38 MAPK,...
-The anti-inflammatory effects of salicylate are well known, but the intracellular mechanisms underlying those remain to be clarified and not explained solely by an influence on cyclooxygenase activity. In present study, we have used cardiac fibroblasts stimulated either angiotensin II (Ang II) or platelet-derived growth factor (PDGF) demonstrate inhibitory effect phosphorylation nonreceptor tyrosine kinases, proline-rich kinase 2 (PYK2) c-Src, immunoprecipitation immunoblotting methods....