A5101671372- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Cervical Cancer and HPV Research
- Economic and Financial Impacts of Cancer
- Occupational and environmental lung diseases
- BRCA gene mutations in cancer
- Nutritional Studies and Diet
- Pancreatic and Hepatic Oncology Research
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Lysosomal Storage Disorders Research
- Health Literacy and Information Accessibility
- Autopsy Techniques and Outcomes
- Consumer Attitudes and Food Labeling
- Hereditary Neurological Disorders
- Menopause: Health Impacts and Treatments
- Skin and Cellular Biology Research
- Cystic Fibrosis Research Advances
- Mental Health and Patient Involvement
- Assisted Reproductive Technology and Twin Pregnancy
- Obesity and Health Practices
- Coal and Coke Industries Research
- Nutrition and Health in Aging
- Delphi Technique in Research
Services Australia
2014-2022
NHS Grampian
2021
Centre international de recherche sur le cancer
2012-2020
World Health Organization - Pakistan
2019
Centre de recherche en Epidémiologie et Santé des Populations
2016
Aarhus University
2016
National Institute for Public Health and the Environment
2016
Inserm
2016
Massey University
2007-2015
King's College Hospital NHS Foundation Trust
2014
BackgroundBreast cancer is the second leading cause of death from in women sub-Saharan Africa, yet there are few well characterised large-scale survival studies with complete follow-up data. We aimed to provide robust estimates this setting and apportion gaps.MethodsThe African Breast Cancer-Disparities Outcomes (ABC-DO) prospective cohort study was done at eight hospitals across five countries (Namibia, Nigeria, South Uganda, Zambia). prospectively recruited (aged ≥18 years) who attended...
Breast cancer is the most common among women and prevention strategies are needed to reduce incidence worldwide. A healthy lifestyle index score (HLIS) was generated investigate joint effect of modifiable factors on postmenopausal breast risk. The study included 242,918 from multinational European Prospective Investigation into Cancer Nutrition (EPIC) cohort, with detailed information diet assessed at baseline. HLIS constructed five (diet, physical activity, smoking, alcohol consumption...
Improving breast cancer survival in sub-Saharan Africa (SSA) is urgently needed, requiring early diagnosis and improved access to treatment. However, data on the types of barriers receiving therapy this region are limited have not been compared between different SSA countries treatment settings. In health care settings across Uganda, Nigeria Namibian sites prospective African Breast Cancer - Disparities Outcomes cohort study, we assessed percentage newly diagnosed patients who received...
Breast cancer (BC) survival rates in sub-Saharan Africa (SSA) are low part due to advanced stage at diagnosis. As one component of a study the entire journey SSA women with BC, we aimed identify shared and setting-specific drivers BC. Women newly diagnosed multicountry African Cancer-Disparities Outcomes (ABC-DO) completed baseline interview their information was extracted from medical records. Ordinal logistic regression used estimate odds ratios (OR) 95% confidence intervals (CI) for (I,...
It has been estimated that at least a third of the most common cancers are related to lifestyle and as such preventable. Key modifiable factors have individually associated with cancer risk; however, less is known about combined effects these factors. This study generated healthy index score (HLIS) investigate joint effect on risk overall cancers, alcohol-related tobacco-related obesity-related reproductive-related cancers. The included 391,608 men women from multinational European...
Introduction Sub-Saharan African (SSA) women with breast cancer (BC) have low survival rates from this potentially treatable disease. An understanding of context-specific societal, health-systems and woman-level barriers to BC early detection, diagnosis treatment are needed. Methods The Breast Cancer—Disparities in Outcomes (ABC-DO) is a prospective hospital-based study overall survival, impact on quality life (QOL) delays along the journey SSA. ABC-DO currently recruiting Namibia, Nigeria,...
Abstract Background There are many proven and suspected occupational causes of lung cancer, which will become relatively more important over time, as smoking prevalence decreases. Methods We interviewed 457 cases aged 20–75 years notified to the New Zealand Cancer Registry during 2007–2008, 792 population controls. collected information on demographic details, potential confounders, employment history. Associations were estimated using logistic regression adjusted for gender, age, ethnicity,...
Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities Outcomes cohort, we dissected diagnostic journey to inform downstaging interventions. At hospital presentation for cancer, women recalled their journey, including dates of first noticing symptoms and health-care provider (HCP) visits. Negative binomial regression models were used identify correlates length journey. Among...
Abstract We examined the geospatial dimension of delays to diagnosis breast cancer in a prospective study 1541 women newly diagnosed African Breast Cancer—Disparities Outcomes (ABC‐DO) Study. Women were recruited at treatment facilities Namibia, Nigeria, Uganda and Zambia. The baseline interview included information used generate features: urban/rural residence, travel mode facility straight‐line distances from home first‐care provider diagnostic/treatment facility, categorized into...
Abstract We conducted a nationwide case‐control study of bladder cancer in adult New Zealanders to identify occupations that may contribute the risk Zealand population. A total 213 incident cases (age 25–70 years) notified Cancer Registry during 2003 and 2004, 471 population controls, were interviewed face‐to‐face. The questionnaire collected demographic information full occupational history. relative risks for associated with ever being employed particular industries calculated by...
Previous studies into occupational risk factors for non-Hodgkin's lymphoma (NHL) in New Zealand have indicated that farmers and meat workers are at increased these neoplasms. A new nationwide case-control study was conducted to assess whether previously observed associations persist identify other occupations may contribute the of NHL population.A total 291 incident cases (age 25-70 years) notified Cancer Registry during 2003 2004, 471 population controls, were interviewed face-to-face. The...
There is limited evidence on the association between dietary folate intake and risk of breast cancer (BC) by hormone receptor expression in tumors. We investigated relationship BC using data from European Prospective Investigation into Cancer Nutrition (EPIC).
The human GLB1 gene produces two alternatively spliced transcripts that encode the lysosomal enzyme β-galactosidase (GLB1) and elastin binding protein (EBP). Mutations at locus, which are responsible for storage disorder GM1 gangliosidosis, may affect either both proteins or only. EBP, when affected, contributes to specific features of gangliosidosis patients, such as cardiomyopathy connective-tissue abnormalities. Here we report development reliable quantitative assays based on real-time...
Since the discovery in 1989 that mutations cystic fibrosis transmembrane conductance regulator (CFTR) underlie (CF), most common life shortening genetic disorder Caucasians, it has been possible to identify heterozygous mutation carriers at risk of having affected children. The Human Genetics Society Australasia produced a position statement with recommendations relation population-based screening for CF. These include: (1) should be offered all relatives people or CF (cascade testing) as...
The definition of population-specific outcomes is an essential precondition for the implementation value-based health care. We developed a minimum standard outcome set overall adult (OAH) to facilitate care in tracking, comparing, and improving adults across multiple conditions, which would be particular relevance primary public populations. International Consortium Health Outcomes Measurement (ICHOM) convened international panel (patients, clinicians, topic experts). Following development...
Background To examine the association between occupation and leukaemia. Methods We interviewed 225 cases (aged 20–75 years) notified to New Zealand Cancer Registry during 2003–04, 471 controls randomly selected from Electoral Roll collecting demographic details, information on potential confounders a comprehensive employment history. Associations leukaemia were analysed using logistic regression adjusted for gender, age, ethnicity smoking. Results Elevated odds ratios (ORs) observed in...
This study investigated the role that demographic and tumour factors play in explaining ethnic inequalities breast cancer survival.Breast cases notified to New Zealand Cancer Registry (NZCR) from April 2005 2007 were followed up 2009. Māori, Pacific non-Māori/non-Pacific women categorised according ethnicity on NZCR. Deprivation was analysed as quintiles of area-based index socio-economic position. Relative survival rates estimated using ethnic-specific life tables. Missing values imputed...
Accurate survival estimates are needed for guiding cancer control efforts in sub-Saharan Africa, but previous studies have been hampered by unknown biases due to excessive loss follow-up (LTFU). In the African Breast Cancer-Disparities Outcomes Study, a prospective breast cohort study, we implemented active mobile health follow-up, telephoning each woman or her next-of-kin (NOK) trimonthly on phone update information vital status. Dates of every contact with women/NOK were analyzed from...