A5063868414- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Pesticide Exposure and Toxicity
- Per- and polyfluoroalkyl substances research
- Pesticide and Herbicide Environmental Studies
- Insect and Pesticide Research
- Air Quality and Health Impacts
- Neuroendocrine regulation and behavior
- Microplastics and Plastic Pollution
- Mycotoxins in Agriculture and Food
- Fatty Acid Research and Health
- Agricultural safety and regulations
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Sex and Gender in Healthcare
- Estrogen and related hormone effects
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Nanoparticles: synthesis and applications
- Environmental Toxicology and Ecotoxicology
- Stress Responses and Cortisol
- Viral Infections and Immunology Research
- Food composition and properties
- Probiotics and Fermented Foods
Istituto Superiore di Sanità
2016-2025
Joint Research Centre
2015
Several studies report that endocrine disrupting chemicals (EDC) able to interfere with homeostasis may affect women's reproductive health. We analyzed EDC serum levels and nuclear receptors (NRs) expression in order have an indication of the internal dose biologically active compounds a measurement indicators their effects, as result repeated uptake from environmental source.The percentage patients detectable bisphenol A (BPA) concentrations was significantly higher infertile compared...
Abstract Bisphenol A (BPA) is a widespread endocrine disrupter mainly used in food contact plastics. Much evidence supports the adverse effects of BPA, particularly on susceptible groups such as pregnant women. The present study considered placental development – relevant for pregnancy outcomes and fetal nutrition/programming potential target BPA. Pregnant CD‐1 mice were administered per os with vehicle, 0.5 (BPA05) or 50 mg kg −1 (BPA50) body weight day from gestational (GD) 1 to GD11. At...
Beauvericin (BEA) and Enniatins (ENN) are mycotoxins produced by Fusarium fungi detected in food feed; there insufficient data to establish their reference values. To evaluate BEA ENN oral toxicity, an integrated approach was applied. Among ENN, Enniatin B (ENNB) selected as test substance. The is composed by: i) vitro acute vivo genotoxicity tests; ii) a repeated‐dose toxicity study focused on genotoxic, immune, endocrine, nervous endpoints the reproductive/developmental screening. For BEA,...
Internal levels of selected endocrine disruptors (EDs) (i.e., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum infertile fertile men from metropolitan, urban rural Italian areas. PFOS PFOA also evaluated seminal plasma. In peripheral blood mononuclear cells (PBMCs) same subjects, gene expression a panel nuclear receptors (NRs), namely estrogen receptor α...
Chlorpyrifos (CPF) is one of the most widely used organophosphate pesticides worldwide. Epidemiological studies on pregnant women and their children suggest a link between in utero CPF exposure delay psychomotor cognitive maturation. A large number animal models have shown adverse effects developing brain more recently endocrine targets. Our aim was to determine if developmental affects social responsiveness associated molecular neuroendocrine markers at adulthood. Pregnant CD1 outbred mice...
Increasing evidence from animal and human studies indicates that chlorpyrifos (CPF), similar to other organophosphorus insecticides still widely used, is a developmental neurotoxicant. Developmental exposure CPF in rodents induces sex-dimorphic behavioral changes at adulthood, including social agonistic responses, which suggests may interfere with maturation of neuroendocrine mechanisms.We assessed the hypothesis affects levels neurohypophyseal hormones acting as modulators behavior mammals,...
Within the PREVIENI project, infertile and fertile women were enrolled from metropolitan, urban rural Italian areas. Blood/serum levels of several endocrine disrupters (EDs) (perfluorooctane sulfonate, PFOS; perfluorooctanoic acid, PFOA; di-2-ethylhexyl-phthalate, DEHP; mono-(2-ethylhexyl)-phthalate, MEHP; bisphenol A, BPA) evaluated concurrently with nuclear receptors (NRs) gene expression (ERa, ERb, AR, AhR, PPARg, PXR) in peripheral blood mononuclear cells (PBMCs). Infertile metropolitan...
Humans are exposed to residues of organophosphate and neonicotinoid pesticides, commonly used in agriculture. Children particularly vulnerable and, among possible adverse outcomes, the increased incidence premature mammary gland development (thelarche) has raised concern. We evaluated toxicological effects chlorpyrifos (CPF), imidacloprid (IMI) glyphosate (GLY) at exposure concentrations occurring children on tumorigenic MCF-7 non-tumorigenic MCF-12A breast cell lines, as representative...
Unhealthy lifestyles, such as chronic consumption of a Western Diet (WD), have been associated with increased systemic inflammation and oxidative stress (OS), condition that may favour cognitive dysfunctions during aging. Polyphenols, rosmarinic acid (RA) buffer low-grade OS, characterizing the aging brain is sustained by WD, promoting healthspan. The aim this study was to evaluate ability RA prevent decline in mouse model WD-driven unhealthy gain knowledge on specific molecular pathways...
Transgender (TG) describes individuals whose gender identity differs from the social norms. TG people undergoing gender-affirming hormone therapy (HT) may be considered a sub-group of population susceptible to environmental contaminants for their targets and modes action. The aim this study is set appropriate HT doses identify specific biomarkers implement animal models. Four adult rats/group/sex were subcutaneously exposed three (plus control) selected starting available data....
Significant evidence supports that many endocrine disrupting chemicals could affect female reproductive health. Aim of this study was to compare the internal exposure bisphenol A (BPA), perfluorooctane sulphonate (PFOS), perfluorooctanoic acid (PFOA), monoethylhexyl phthalate (MEHP), and di(2-ethylhexyl) (DEHP) in serum samples 111 infertile women 44 fertile women. Levels gene expression nuclear receptors (ER α , ER β AR, AhR, PXR, PPAR γ ) were also analyzed as biomarkers effective dose....
Lactococcus lactis is one of the most important microorganisms in dairy industry and has "generally recognized as safe" (GRAS) status. L. belongs to group lactic acid bacteria (LAB) encountered a wide range environments. Recently, use intramammary infusion live culture LAB been investigated new antibiotic alternative for treating mastitis ruminants. Controversial results are described literature regarding its efficacy safety. In this study we conducted in-depth investigation mammary gland...
Obesity, and the obesity-associated inflammation, represents a major risk factor for development of chronic diseases, including colorectal cancer (CRC). Dysfunctional visceral adipose tissue (AT) is now recognized as key player in morbidities, although biological processes underpinning increased CRC obese subjects are still matter debate. Recent findings have pointed to specific alterations expression pattern non-coding RNAs (ncRNAs), such microRNAs (miRNAs), long (lncRNAs), mechanisms...
The general population (including children) is exposed to chemical mixtures. Plasticizers such as Bisphenol A (BPA) and Phthalates (mainly Bis(2-ethylhexyl) phthalate-DEHP) are widespread contaminants classified endocrine disrupters which share some toxicological profiles coexist in food environment.