A5036895632- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Galectins and Cancer Biology
- Celiac Disease Research and Management
- Trace Elements in Health
- Trypanosoma species research and implications
- RNA Interference and Gene Delivery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Research on Leishmaniasis Studies
- RNA Research and Splicing
- Fatty Acid Research and Health
- Toxin Mechanisms and Immunotoxins
- Lipid metabolism and disorders
- Cellular Mechanics and Interactions
- Metabolomics and Mass Spectrometry Studies
- Microscopic Colitis
- Adrenal Hormones and Disorders
- Immune Cell Function and Interaction
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Heavy Metal Exposure and Toxicity
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2024
Bambino Gesù Children's Hospital
2012-2024
University of Bari Aldo Moro
2019-2022
Boston Children's Hospital
2013
BackgroundCeliac Disease (CD) is a multifactorial autoimmune enteropathy (with prevalence of approximately 1% worldwide) that exhibits wide spectrum clinical, serological and histological manifestations. For the diagnosis paediatric CD, gold standard combination tests high TGA-IgA values greater than 10 times upper limit normal) duodenal biopsy positive but low titer). Therefore, diagnostic test totally excludes an invasive approach has not been discovered so far discovery novel biological...
Human serum IgM Abs are composed of heavily glycosylated polymers with five glycosylation sites on the μ (heavy) chain and one site J chain. In contrast to IgG glycans, which vital for a number biological functions, virtually nothing is known about structure-function relationships glycans. Natural earliest Ig produced recognizes multiple Ags low affinity, whereas immune induced by Ag exposure characterized higher specificity. anti-lymphocyte present in healthy individuals increases...
Summary Background Circulating microRNAs (miRNAs) may act as biomarkers of metabolic disturbances. Objective The aim this study was to identify serum miRNAs signature early insulin resistance in obese preschoolers. Methods Twelve children, aged 2–6 years, six resistant (IR) and controls were selected being age‐matched, sex‐matched body mass index‐matched. Profiling 179 circulating miRNAs, known be widely expressed the bloodstream, investigated by quantitative polymerase chain reaction at...
Obesity, a low-grade inflammatory condition, represents major risk factor for the development of several pathologies including colorectal cancer (CRC). Although adipose tissue state is now recognized as key player in obesity-associated morbidities, underlying biological processes are complex and not yet precisely defined. To this end, we analyzed transcriptome profiles human visceral adipocytes from lean obese subjects affected or by CRC RNA sequencing (n=6 subjects/category), validated...
Obesity, and the obesity-associated inflammation, represents a major risk factor for development of chronic diseases, including colorectal cancer (CRC). Dysfunctional visceral adipose tissue (AT) is now recognized as key player in morbidities, although biological processes underpinning increased CRC obese subjects are still matter debate. Recent findings have pointed to specific alterations expression pattern non-coding RNAs (ncRNAs), such microRNAs (miRNAs), long (lncRNAs), mechanisms...
The effect of Leishmania infantum soluble antigen (LSA) and recombinant Kinetoplastid Membrane Protein 11 (rKMP11) on the induction ex vivo specific IFN-γ (n = 69) antibody responses 108) was determined in dogs. All dogs were tested for serological response to both antigens divided into Group 1: healthy (Asturias, Spain, n 26), 2: sick 46), 3: Ibizan hounds (Mallorca, 22) 4: (Bari, Italy, 14). Antibody levels higher LSA when compared rKMP11 (p 0.001). all seronegative 18% low seropositive...
MicroRNAs (miRNAs) are a class of small noncoding RNAs acting as post-transcriptional gene expression regulators in many physiological and pathological conditions. During the last few years, novel mammalian miRNAs have been predicted experimentally with bioinformatics approaches validated by next-generation sequencing. Although these strategies prompted discovery several miRNAs, total number genes still seems larger. Here, exploiting species conservation human, mouse, rat hairpin we...
In recent years, the clinical use of extracellular miRNAs as potential biomarkers disease has increasingly emerged a new and powerful tool. Serum, urine, saliva stool contain that can exert regulatory effects not only in surrounding epithelial cells but also modulate bacterial gene expression, thus acting "master regulator" many biological processes. We think order to have holistic picture health status an individual, we consider comprehensively "omics" data, such profiling form different...
Toll-like receptor (TLR)7/8 plays a crucial role in host recognition/response to viruses and its mucosal expression directly correlates with intestinal inflammation. The aim of this study was investigate the TLR7/8 stimulation epithelium shaping phenotype functions innate immunity cell subsets, define direct and/or epithelial cell-mediated mechanisms agonist R848 immunomodulatory activity. We describe novel, TLR8-mediated, pro- anti-inflammatory effects on ex-vivo cultured human blood...
After the increasing number of SARS-CoV-2 infections all over world, researchers and clinicians are struggling to find a vaccine or innovative therapeutic strategies treat this viral infection. The SARS-CoV infection that occurred in 2002, MERS other more common infectious diseases such as HCV, led discovery many RNA-based drugs. Among them, siRNAs antisense LNAs have been demonstrated effective antiviral effects both animal models humans. Owing high genomic homology (80-82%) use these...
Colorectal cancer (CRC) is a major life-threatening disease, being the third most common and leading cause of death worldwide. Enhanced adiposity, particularly visceral fat, risk factor for CRC, obesity-associated alterations in metabolic, inflammatory immune profiles adipose tissue (VAT) strongly contribute to promoting or sustaining intestinal carcinogenesis. The role diet nutrition obesity CRC has been extensively demonstrated, AT represents main place where diet-induced signals are...
Abstract This case report describes the clinical, dermoscopic and histopathological findings of three different neoplastic lesions (angiokeratoma, squamous cell carcinoma multiple melanocytomas) non‐tumoral skin in a hairless Chinese crested dog following chronic sun exposure. The was characterized by “sunburn cells”, collagen degeneration, dermal elastosis fibrosis, described most species as caused UV light Cutaneous angiokeratomas have been rarely reported canine literature. In this...
<h3>Background</h3> Fibromyalgia (FM) is a syndrome characterized by chronic widespread pain that affects about 2–8% of the general population, especially female gender [1].The pathogenesis FM not completely understood and diagnosis clinical.MicroRNAs, class small non-coding RNAs ∼22–24 nucleotides, are involved in different post-transcriptional processes have been identified as important biomarkers many diseases [2]. Recently, it has hypothesized modulation protein expression, potentially...
Canine leishmaniosis (CanL) due to Leishmania infantum is characterized by the development of both cellular and humoral immune responses. The dysfunction T cell-mediated immunity leads a lack proliferation cells in response antigens with consequence parasite dissemination that seems be related cell exhaustion mediated regulatory B expressing immunoglobulin D (IgD). aim this study was determine compare total serum IgD dogs clinical clinically healthy dogs. A 147 dog sera were studied. All...