A5008325134- Extracellular vesicles in disease
- Lipid Membrane Structure and Behavior
- Bacterial Infections and Vaccines
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Microscopic Colitis
- Moringa oleifera research and applications
- interferon and immune responses
- Aquaculture Nutrition and Growth
- RNA modifications and cancer
- Quantum, superfluid, helium dynamics
- Celiac Disease Research and Management
- Viral Infections and Immunology Research
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Nanopore and Nanochannel Transport Studies
- Food Allergy and Anaphylaxis Research
Bambino Gesù Children's Hospital
2020-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2022
Roma Tre University
2022
It is widely acknowledged that mammalian exosomes (or extracellular vesicles), have a key role in intercellular communication, owing to the presence of various bioactive molecules such as lipids, proteins, and microRNAs within their inner compartment. Most recently, discovery vesicles isolated from edible plants (such vegetables fruits) similarity terms size content with has opened new perspectives on possible communication regulation important biological processes which these are involved....
Dynamic Light Scattering (DLS), Small Angle X-ray (SAXS) and Transmission Electron Microscopy (TEM) are physical techniques widely employed to characterize the morphology structure of vesicles such as liposomes or human extracellular (exosomes). Bacterial similar in size exosomes, although their function membrane properties have not been elucidated detail case exosomes. Here, we applied above cited techniques, synergy with thermodynamic characterization lipid using a turbidimetric technique...
A balanced diet is critical for human health, and edible plants play an important role in providing essential micronutrients as well specific microRNAs (miRNAs) that can regulate gene expression. Here we present the effects of Moringa oleifera (MO) miRNAs (mol-miRs) on lipid metabolism. Through silico studies identified potential genes involved metabolism targeted by mol-miRs. To this end, tested efficacy aqueous extract MO seeds (MOES), suggested traditional African ethnomedicine, or its...
In recent years, the clinical use of extracellular miRNAs as potential biomarkers disease has increasingly emerged a new and powerful tool. Serum, urine, saliva stool contain that can exert regulatory effects not only in surrounding epithelial cells but also modulate bacterial gene expression, thus acting "master regulator" many biological processes. We think order to have holistic picture health status an individual, we consider comprehensively "omics" data, such profiling form different...
After the increasing number of SARS-CoV-2 infections all over world, researchers and clinicians are struggling to find a vaccine or innovative therapeutic strategies treat this viral infection. The SARS-CoV infection that occurred in 2002, MERS other more common infectious diseases such as HCV, led discovery many RNA-based drugs. Among them, siRNAs antisense LNAs have been demonstrated effective antiviral effects both animal models humans. Owing high genomic homology (80-82%) use these...
Dynamic Light Scattering (DLS), Small Angle X-ray (SAXS) and Transmission Electron Microscopy (TEM) are physical techniques widely employed to characterize the morphology structure of vesicles such as liposomes or human extracellular (exosomes). Bacterial similar in size exosomes, although their function membrane properties have not been elucidated detail case exosomes. Here, we applied above cited techniques, synergy with thermodynamic characterization lipid using a turbidimetric technique...