A5002812160- Celiac Disease Research and Management
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Galectins and Cancer Biology
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Microbial Metabolites in Food Biotechnology
- Extracellular vesicles in disease
- Food Allergy and Anaphylaxis Research
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- interferon and immune responses
- Food composition and properties
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Immunodeficiency and Autoimmune Disorders
- Intestinal and Peritoneal Adhesions
- SARS-CoV-2 and COVID-19 Research
Bambino Gesù Children's Hospital
2017-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2022
Istituto Superiore di Sanità
2011-2014
BackgroundCeliac Disease (CD) is a multifactorial autoimmune enteropathy (with prevalence of approximately 1% worldwide) that exhibits wide spectrum clinical, serological and histological manifestations. For the diagnosis paediatric CD, gold standard combination tests high TGA-IgA values greater than 10 times upper limit normal) duodenal biopsy positive but low titer). Therefore, diagnostic test totally excludes an invasive approach has not been discovered so far discovery novel biological...
Celiac disease (CD) is an autoimmune enteropathy, triggered by dietary gluten. The only treatment a strict gluten-free diet. Oats are included in the list of ingredients European Regulation, but safety oats CD still matter debate. present study examined capability different oat cultivars activating gliadin-induced transglutaminase-2 (TG2)-dependent events some vitro models CD. In addition, we compared this with electrophoresis pattern peptic-tryptic digests proteins cultivars.K562(S) cells...
Celiac Disease (CD) is a chronic inflammatory enteropathy, triggered in genetically susceptible individuals by dietary gluten. Gluten able to elicit proliferation of specific T cells and secretion cytokines the small intestine. In this study we investigated possibility that p10-mer, decapeptide from durum wheat (QQPQDAVQPF), which was previously shown prevent activation celiac peripheral lymphocytes, may exert an inhibitory effect on peptic-tryptic digested gliadin (PT-Gly)-stimulated...
Objective. Celiac disease (CD) has strongly been established as associated with some site-specific gastrointestinal malignancies. On the contrary, according to few reports available, risk of colon carcinoma in CD patients described similar that general population. In this cohort study, we describe a group Italian celiac patients. Materials and methods. The study population included all diagnosed at Collaborating Centers Registry between 1st January 1982 31st December 2006. Upon diagnosis...
In recent years, the clinical use of extracellular miRNAs as potential biomarkers disease has increasingly emerged a new and powerful tool. Serum, urine, saliva stool contain that can exert regulatory effects not only in surrounding epithelial cells but also modulate bacterial gene expression, thus acting "master regulator" many biological processes. We think order to have holistic picture health status an individual, we consider comprehensively "omics" data, such profiling form different...
Background The mucosal tissues play a central role in the transmission of HIV-1 infection as well pathogenesis AIDS. Despite several clinical studies reported intestinal dysfunction during HIV infection, mechanisms underlying HIV-induced impairments epithelial barrier are still unclear. It has been postulated that alters enterocytic function and proteins have detected cell types mucosa. In present study, we analyzed effect accessory Nef protein on human line. Methodology/Principal Findings...
After the increasing number of SARS-CoV-2 infections all over world, researchers and clinicians are struggling to find a vaccine or innovative therapeutic strategies treat this viral infection. The SARS-CoV infection that occurred in 2002, MERS other more common infectious diseases such as HCV, led discovery many RNA-based drugs. Among them, siRNAs antisense LNAs have been demonstrated effective antiviral effects both animal models humans. Owing high genomic homology (80-82%) use these...