A5086072296- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Oral health in cancer treatment
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Salivary Gland Tumors Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Advances in Oncology and Radiotherapy
- Colorectal and Anal Carcinomas
- Cancer survivorship and care
- Nonmelanoma Skin Cancer Studies
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Multiple and Secondary Primary Cancers
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Polyomavirus and related diseases
Institut de Cancérologie Strasbourg
2011-2024
Levi Strauss (United States)
2017-2022
Inserm
2020
Centre de Radiothérapie Bayard
2020
Gefluc Languedoc Roussillon
2011-2019
Eurométropole de Strasbourg
2011-2018
Interface (United States)
2018
Hôpital d'Hautepierre
2017
Université de Strasbourg
2015-2016
Xerostomia is a major toxic effect associated with intensity-modulated radiotherapy (IMRT) for oropharyngeal cancers.
Patients with human papillomavirus (HPV)-related oropharyngeal tumors display improved prognosis. The biological basis of this tumor phenotype is poorly understood. We investigated whether increased lymphocyte infiltrate in HPV-positive squamous cell carcinomas could account for better previously identified, an Affymetrix GeneChip analysis 83 HPV-unrelated and 11 HPV-related carcinoma the oropharynx, several candidate genes, including CD8α CD3ζ. Their expression was validated study by...
// Nathalie Bonnin 1, 2, 3 , Emma Armandy Julien Carras 2 Sylvain Ferrandon Priscillia Battiston-Montagne Marc Aubry 4, 5, 6 Sébastien Guihard 7 David Meyronet 3, 8 Jean-Philippe Foy 9 Pierre Saintigny Sonia Ledrappier Alain Jung Ruth Rimokh 10 Claire Rodriguez-Lafrasse 11 Delphine Poncet 10, 1 Hospices Civils de Lyon, France EMR3738, Equipe Radiobiologie Cellulaire et Moléculaire, Faculté Médecine Lyon Sud - Charles Mérieux, Oullins, Université 4 Rennes Européenne Bretagne, Biosit,...
We performed a cost-effectiveness analysis (CEA) comparing an adaptive radiotherapy (ART) strategy, based on weekly replanning, aiming to correct the parotid gland overdose during treatment and expecting therefore decrease xerostomia, when compared standard IMRT. conducted ARTIX trial, randomized, parallel-group, multicentric study systematic replanning ART The primary endpoint was frequency of xerostomia at 12 months, measured by stimulating salivary flow with paraffin. CEA designed...
Human papillomavirus (HPV)-related oropharyngeal cancer represents a distinct head and neck squamous cell carcinoma (HNSCC) subpopulation, with improved disease-free overall survival. In general, HPV-positive HNSCCs express wild-type TP53, which could explain its increased radiosensitivity. However, the molecular mechanisms underlying this higher sensitivity remain elusive. We have previously shown that HPV-related carcinomas decreased levels of NEDD8-activating enzyme 1/amyloid β precursor...
Abstract Background Large-scale trials have shown that hypofractionated adjuvant breast radiotherapy was as effective in terms of survival and local control conventional fractionated radiotherapy, acute toxicity reduced with radiotherapy. However, there is a lack data about the regional nodal irradiation (RNI). The aim this study to assess effect fractionation on radiation-related skin patients receiving RNI addition whole-breast or chest wall irradiation, using real-life data. Methods We...
Head and neck squamous cell carcinomas (HNSCCs) are heterogeneous tumors, well known for their frequent relapsing nature. To counter recurrence, biomarkers early diagnosis, prognosis, or treatment response prediction urgently needed. miRNAs can profoundly impact normal physiology enhance oncogenesis. Among all of the miRNAs, miR-30 family is frequently downregulated in HNSCC. Here, we determined how levels 3p passenger strands miR-30a miR-30e affect tumor behavior clarified functional role...
Radiation therapy is a well-recognized, effective modality used for palliative care. Most studies completed to date have endpoints of one month or greater after treatment completion. This study analyzed the response rates at different time points during first treatment.From May 2010 November 2011, 61 patients treated 74 metastases were included in study. The end defined as completion (CT) and d8, d15 d30 treatment. rate was measured by worst pain last 24 hours administered opioid dose....
Background: Anxiety impacts patient outcomes and quality of life in response to cancer diagnosis. A prospective phase 3 trial randomizing 126 patients was conducted determine whether a specific one-on-one procedure announcement provided by radiation therapist before CT scan simulation decreases anxiety for with breast requiring radiotherapy. Material Methods: measured using the STAI form, QLQ-C30 BR-23 questionnaires were used evaluate life. Results: Mean trait or state scores simulation,...
For most patients suffering from recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC), chemotherapy is the main option after considering surgery reirradiation. Cetuximab combined with a platinum-fluorouracil regimen (EXTREME) has been standard of care for over decade. Nevertheless, significant number remain unfit this because age, severe comorbidities, or poor performance status. The aim study to investigate an alternative sufficient efficacy safety.We reviewed...
Moderately hypofractionated whole-breast radiotherapy (HFRT) has proven to be as safe and efficient normofractionated (NFRT) in randomized trials resulting major changes clinical practice. Toxicity rates observed selected trial patients may differ from those unselected with possible comorbidities frailty real-life. This study aimed examine the influence of HFRT versus NFRT on acute toxicity identify risks factors dermatitis real-life patients.Prospective data breast cancer patients, treated...