Derek K. Chu
A5079201163- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
- IL-33, ST2, and ILC Pathways
- Respiratory and Cough-Related Research
- Infection Control and Ventilation
- Clinical practice guidelines implementation
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Meta-analysis and systematic reviews
- Health Systems, Economic Evaluations, Quality of Life
- Long-Term Effects of COVID-19
- Health and Medical Studies
- COVID-19 and healthcare impacts
- Health Policy Implementation Science
- COVID-19 and Mental Health
- Nasal Surgery and Airway Studies
- Sepsis Diagnosis and Treatment
- Pharmaceutical studies and practices
McMaster University
2015-2024
Impact
2019-2024
St. Joseph’s Healthcare Hamilton
2019-2024
ENT and Allergy
2021-2024
Stanford University
2024
McMaster University Medical Centre
2013-2023
Bellevue College
2023
Department of Health Research
2020-2022
Bridge University
2022
Ontario Clinical Oncology Group
2022
### What you need to know What is the best way use oxygen therapy for patients with an acute medical illness? A systematic review published in Lancet April 2018 found that supplemental inpatients normal saturation increases mortality.1 Its authors concluded should be administered conservatively, but they did not make specific recommendations on how do it. An international expert panel used inform this guideline. It aims promptly and transparently translate potentially practice-changing...
Abstract Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care pathways differences between national or regional Better understanding of the mechanisms has enabled stratified approach management severe asthma, supporting use targeted treatments with biologicals. However, there are still many issues that require further clarification. These include selection certain...
Abstract This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy was developed using the Grading Recommendations, Assessment, Development Evaluations (GRADE) approach. Food diagnosis starts with an allergy‐focused clinical history followed by tests to determine IgE sensitization, such as serum allergen‐specific (sIgE) skin prick test (SPT), basophil activation (BAT), if available. Evidence sensitization should be...
<h2>Abstract</h2> This practice parameter update focuses on 7 areas in which there are new evidence and recommendations. Diagnostic criteria for anaphylaxis have been revised, patterns of defined. Measurement serum tryptase is important diagnosis to identify underlying mast cell disorders. In infants toddlers, age-specific symptoms may differ from older children adults, patient age not correlated with reaction severity, unlikely be the initial an allergen first exposure. Different community...
An evidence-based approach is considered the gold standard for health decision-making. Sometimes, a guideline panel might judge certainty that desirable effects of an intervention clearly outweigh its undesirable as high, but body supportive evidence indirect. In such cases, application Grading Recommendations, Assessment, Development and Evaluations (GRADE) grading strength recommendations inappropriate. Instead, GRADE Working Group has recommended developing ungraded best or good practice...
Atopic dermatitis (AD) is an inflammatory skin condition with multiple systemic treatments and uncertainty regarding their comparative impact on AD outcomes.
Cow's milk allergy (CMA) is the most common food in infants. The replacement with specialized formulas an established clinical approach to ensure adequate growth and minimize risk of severe allergic reactions when breastfeeding not possible. Still, given availability multiple options, such as extensively hydrolyzed cow's protein formula (eHF-CM), amino acid (AAF), rice (HRF) soy (SF), there some uncertainty suitable choice respect health outcomes. Furthermore, addition probiotics a has been...
Eosinophils natively inhabit the small intestine, but a functional role for them there has remained elusive. Here, we show that eosinophil-deficient mice were protected from induction of Th2-mediated peanut food allergy and anaphylaxis, Th2 priming was restored by reconstitution with il4+/+ or il4−/− eosinophils. controlled CD103+ dendritic cell (DC) activation migration intestine to draining lymph nodes, events necessary priming. Eosinophil in vitro vivo led degranulation eosinophil...