A5074604408- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Blood transfusion and management
- Radiomics and Machine Learning in Medical Imaging
- Gallbladder and Bile Duct Disorders
- Meta-analysis and systematic reviews
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Venous Thromboembolism Diagnosis and Management
- Hernia repair and management
- Anesthesia and Pain Management
- Intestinal and Peritoneal Adhesions
- Organ Transplantation Techniques and Outcomes
- Hip and Femur Fractures
- Esophageal and GI Pathology
- Trauma and Emergency Care Studies
- Liver Disease and Transplantation
- Gastrointestinal Tumor Research and Treatment
- MRI in cancer diagnosis
- Pain Management and Opioid Use
- Palliative Care and End-of-Life Issues
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2016-2025
University of Toronto
2016-2025
Sunnybrook Research Institute
2017-2025
Sunnybrook Hospital
2013-2024
Institute for Clinical Evaluative Sciences
2018-2024
Public Health Ontario
2024
University Hospital Southampton NHS Foundation Trust
2023
University of Helsinki
2023
Helsinki University Hospital
2023
### What you need to know What is the best way use oxygen therapy for patients with an acute medical illness? A systematic review published in Lancet April 2018 found that supplemental inpatients normal saturation increases mortality.1 Its authors concluded should be administered conservatively, but they did not make specific recommendations on how do it. An international expert panel used inform this guideline. It aims promptly and transparently translate potentially practice-changing...
IMPORTANCE Trauma is the leading cause of death among US children.Whether pediatric trauma centers (PTCs), mixed (MTCs), or adult (ATCs) offer a survival benefit compared with one another when treating injured children controversial.Ascertaining optimal care environment will better inform quality improvement initiatives and accreditation standards.OBJECTIVE To evaluate association between type center (PTC, MTC, ATC) in-hospital mortality young (5 years younger), older (aged 6-11 years),...
Instruments that are useful in clinical or research practice will, when the object of measurement is stable, yield similar results applied at different times, situations, by users. Studies measure relation differences between patients subjects and error (reliability studies) becoming increasingly common orthopaedic literature. In this paper, we identify aspects reliability studies suggest features improve reader's confidence results. One concept serves as foundation for all further...
Purpose Improvement in the quality of life patients with cancer requires attention to symptom burden across continuum care, use patient-reported outcomes key achieving optimal care. Yet there have been few studies that examined symptoms early postdiagnosis period during which suboptimal control may be common. A comprehensive analysis temporal trends and risk factors for newly diagnosed is essential guide supportive care strategies. Methods retrospective observational study was performed who...
Objective: The objective of this study was to test the hypothesis that distal pancreatectomy (DP) without intraperitoneal drainage does not affect frequency grade 2 or higher complications. Background: use routine drains during DP is controversial. Prior study, no prospective trial focusing on has been reported. Methods: Patients undergoing for all causes at 14 high-volume pancreas centers were preoperatively randomized placement a drain drain. Complications and their severity tracked 60...
Gastrectomy remains a major operation with potential for significant deterioration in patients' health-related quality of life (QOL). This study assessed differences QOL among patients after distal (DG), proximal (PG), or total (TG) gastrectomy.We prospectively enrolled undergoing gastrectomy at our institution between 2002 and 2007. Participants completed the European Organization Research Treatment Cancer cancer (QLQ-C30) gastric (QLQ-STO22) questionnaires preoperatively 5 postoperative...
To assess whether CT-derived texture features predict survival in patients undergoing resection for pancreatic ductal adenocarcinoma (PDAC). Thirty with pre-operative CT from 2007 to 2012 PDAC were included. Tumor size and five namely uniformity, entropy, dissimilarity, correlation, inverse difference normalized calculated. Mann–Whitney rank sum test was used compare tumor normal pancreas. Receiver operating characteristics (ROC) analysis, Cox regression Kaplan-Meier tests association of...
<h3>Importance</h3> Motor vehicle crashes (MVCs) are a leading public health concern. Emergency medical service (EMS) response time is modifiable, system-level factor with the potential to influence trauma patient survival. The relationship between EMS and MVC mortality unknown. <h3>Objectives</h3> To measure association times at population level across US counties. <h3>Design, Setting, Study Population</h3> This population-based study included MVC-related deaths in 2268 counties,...
Adhesive small-bowel obstruction (aSBO) is a potentially chronic, recurring surgical illness. Although guidelines suggest trials of nonoperative management, the long-term association this approach with recurrence poorly understood.To compare incidence aSBO in patients undergoing operative management at their first admission compared management.This longitudinal, propensity-matched, retrospective cohort study used health administrative data for province Ontario, Canada, treated from April 1,...
We set out to compare the incidence of bowel repair and/or resection in a large cohort patients with adhesive small obstruction (SBO) managed operatively.Laparoscopic lysis adhesions for SBO (aSBO) is becoming more common, yet might increase risk injury given distended potentially compromised bowel.We used administrative discharge data derived from geographic region, identifying who underwent surgery their first episode aSBO during 2005 2014. Procedure codes were determine exposure: either...
Abstract In this work, we assess the reproducibility and prognostic value of CT-derived radiomic features for resectable pancreatic ductal adenocarcinoma (PDAC). Two radiologists contoured tumour regions on pre-operative CT two cohorts from institutions undergoing curative-intent surgical resection PDAC. The first (n = 30) second 68) were used training validation proposed model overall survival (OS), respectively. Radiomic extracted using PyRadiomics library those with weak inter-reader...
Tranexamic acid reduces bleeding and blood transfusion in many types of surgery, but its effect patients undergoing liver resection for a cancer-related indication remains unclear.
Ablative therapies extend the capability of delivering potentially curative treatment for bilateral hepatic colorectal metastases.To compare long-term effectiveness ablation with that resection in patients metastases.Review a prospective database 2123 operative cases metastases.A large institution expertise and resection.Patients liver metastases undergoing operation intent. A total 141 had been treated (BR) 95 undergone ablation.Radiofrequency or microwave alone combination (A/R) compared...