A5100607355- Genetic Associations and Epidemiology
- Clinical practice guidelines implementation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Pharmacological Effects of Natural Compounds
- Hormonal and reproductive studies
- COVID-19 and healthcare impacts
- Hormonal Regulation and Hypertension
- Kidney Stones and Urolithiasis Treatments
- Tuberculosis Research and Epidemiology
- Pediatric Urology and Nephrology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Sexual Differentiation and Disorders
- Circular RNAs in diseases
- Birth, Development, and Health
- Healthcare cost, quality, practices
- Coffee research and impacts
- Healthcare and Venom Research
- Conferences and Exhibitions Management
- COVID-19 Pandemic Impacts
- Mycobacterium research and diagnosis
- Enhanced Recovery After Surgery
- Complementary and Alternative Medicine Studies
- Prostate Cancer Treatment and Research
Sichuan University
2018-2025
Humanitas University
2025
McMaster University
2025
Impact
2025
Department of Health Research
2025
University of Manchester
2025
Beijing Union University
2025
China Medical University
2020-2024
West China Hospital of Sichuan University
2018-2024
Fourth Affiliated Hospital of China Medical University
2024
An evidence-based approach is considered the gold standard for health decision-making. Sometimes, a guideline panel might judge certainty that desirable effects of an intervention clearly outweigh its undesirable as high, but body supportive evidence indirect. In such cases, application Grading Recommendations, Assessment, Development and Evaluations (GRADE) grading strength recommendations inappropriate. Instead, GRADE Working Group has recommended developing ungraded best or good practice...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is the main cause for hepatocellular carcinoma (HCC). This study was intended to identify function of long non-coding RNA (lncRNA) lncARSR in NAFLD and its role human HCC cells (HepG2) proliferation invasion. Methods LncARSR expression detected both high acid-treated HepG2 mouse model. After gain- loss-of-function approaches mice, lipid accumulation livers from mice determined by H&E staining, Oil Red-O staining or Nile Red...
Objective Pancreatic cancer is associated with poor prognosis and dismal survival rates. This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by pancreatic stellate cells (PSCs) in Gemcitabine (Gem) resistance under hypoxia, which involves the methylation SOCS3 EZH2 recruitment. Methods The were isolated from PSCs hypoxic (HPSCs), co-cultured transduced manipulated UCA1, EZH2, SOCS3. interaction among was characterized RIP ChIP assays. Next, MTT assay, flow cytometry...
BackgroundHealth equity aims to provide all individuals with equal and fair opportunities achieve optimal health. Practice guidelines can play a pivotal role in advancing health equity, yet, few organizations utilize tools systematically integrate considerations. Thus, it is important establish foundation for practical support the systematic integration of This manuscript proposes principles considerations practice guideline enterprise.MethodsIn process developing an extension GIN-McMaster...
Objective: T cell-mediated rejection (TCMR) is a major concern following liver transplantation (LT), and identifying its predictors could help improve post-transplant prognosis. This study aimed to develop model predict the risk of TCMR in children adults after LT. Method: Pre-transplant demographic characteristics, intraoperative parameters, especially early laboratory data for 1,221 LT recipients (1,096 125 children) were obtained from Hospital, University, between 1 January 2015, 2022....
miR-196b-5p expression is deregulated in many malignant tumors. Although has been implicated the transformation of colorectal cancer, its role this specific type cancer not fully explored. Thus, present study was aimed to examine cellular function and biological behavior cancer.miR-196b-5p measured tissues cell lines using quantitative real-time PCR. Cell counting kit-8 (CCK-8) assay Transwell were used detect proliferation, migration, invasion lines, whereas flow cytometry applied...
The aim of this study was to examine the association between coffee and prostate cancer. Firstly, we conducted an observational using data from National Health Nutrition Examination Survey (NHANES) 1999–2010. Coffee intake derived 24 h dietary recalls. Weighted multivariable-adjusted logistic regression applied evaluate association. Then, performed Mendelian randomization (MR) explore possible causal effect on cancer risk. Primary secondary genetic instruments were obtained genome-wide...
No consensus exists about the causal relationship between vitamin D (VD) and male factor infertility due to heterogeneity confounding factors even in randomized controlled trials (RCTs). This study aimed investigate association 25 hydroxyvitamin (25OHD) levels through Mendelian randomization (MR) provide complementary information for optimization of future RCTs.Two-sample MR analyses with four steps were performed. Single-nucleotide polymorphisms (SNPs) VD extracted from 417,580 Europeans UK...
Abstract Background The causal effects of individual risk factors metabolic syndrome on erectile dysfunction (ED) are still unclear. Objectives To evaluate the effect ED through Mendelian randomization (MR). Materials and methods Data for were obtained from multiple databases with 173,082–757,601 individuals, that collected a genome‐wide association study including 223,805 Europeans. We performed univariate MR analysis using inverse‐variance weighted, MR‐Egger, weighted‐median, weighted mode...
BackgroundUrinary incontinence (UI) is a common health problem that affects the quality of life and millions people in United States (US). We aimed to investigate association between sitting time UI symptoms US population.MethodsA cross-sectional survey participants aged 20 above from National Health Nutrition Examination Survey 2007–2018 was performed. A self-report questionnaire reported complete data on UI, covariates included. Weighted multivariable logistic regression models were used...
Background: The impact of educational attainment (EA) on multiple urological and reproductive health outcomes has been explored in observational studies. Here we used Mendelian randomization (MR) to investigate whether EA causal effects 14 outcomes. Methods: We obtained summary statistics for from genome-wide association studies (GWAS). MR analyses were applied explore the potential between them. Inverse variance weighted was primary analytical method. Results: Genetically predicted one...
This study aimed to investigate whether testosterone mediates or confounds the effect of obesity-related traits on prostate cancer (PCa) using Mendelian randomization (MR) analysis.Data (body mass index [BMI], waist-to-hip ratio [WHR], and adjusted for body [WHRadjBMI]) were obtained from up 806,834 people European ancestry; data (bioavailable [BT], total [TT], sex hormone-binding globulin [SHBG]) extracted 194,453 participants in UK Biobank; summary-level PCa (79,194 cases 61,112 controls)...
Abstract Anaesthetics are commonly applied in pharmacokinetic (PK) studies to assure smooth handling of experimental procedures or promote animal welfare. However, the influence anaesthetics on PK co‐administered drug is generally unknown but assumes ignorable. The goal study was investigate effect tricaine methanesulfonate (MS‐222), 2‐phenoxyethanol (2‐PE) and eugenol (EUG) florfenicol (FF) Nile tilapia. Twenty‐eight fish were repeatedly exposed 90 ppm EUG, 300 MS‐222 900 2‐PE before FF...