Luís Taborda‐Barata
A5045743473- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Food Allergy and Anaphylaxis Research
- Inhalation and Respiratory Drug Delivery
- Contact Dermatitis and Allergies
- Respiratory and Cough-Related Research
- Dermatology and Skin Diseases
- Mobile Health and mHealth Applications
- Eosinophilic Esophagitis
- Air Quality and Health Impacts
- Lung Cancer Diagnosis and Treatment
- Delphi Technique in Research
- IL-33, ST2, and ILC Pathways
- Medication Adherence and Compliance
- Mast cells and histamine
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Occupational exposure and asthma
- Digital Mental Health Interventions
- Climate Change and Health Impacts
- Food Safety and Hygiene
- COVID-19 and healthcare impacts
- Health Literacy and Information Accessibility
- Nasal Surgery and Airway Studies
University of Beira Interior
2016-2025
Hospital Center of Cova da Beira
2016-2025
Universidade do Porto
2024
Centre for Health Technology and Services Research
2024
Odense University Hospital
2023
Luxembourg Institute of Health
2023
Charité - Universitätsmedizin Berlin
2021
Humboldt-Universität zu Berlin
2021
Clinical Academic Center of Braga
2020
Hospitais da Universidade de Coimbra
2020
The relationship of expression the C-C chemokines eotaxin, eotaxin 2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4 to kinetics infiltrating eosinophils, basophils, other inflammatory cells was examined in allergen-induced, late-phase allergic reactions skin human atopic subjects. EG2+ eosinophils peaked at 6 h correlated significantly with mRNA protein, whereas declining 24 eotaxin-2 mRNA. In contrast, no significant correlations were observed between BB1+ basophil...
Human eosinophils are cytokine-producing cells that prominent in IgE-dependent allergic tissue reactions. IL-4 promotes the development of Th2-type phenotype T and is an essential cofactor for IgE production by B cells. We detected mRNA reverse transcription-PCR blood from atopic asthmatics. By specific ELISA, 108 +/- 20 pg protein/10(6) could be extracted whole cells, approximately 30% was released after incubation with serum-coated particles. Using immunocytochemistry, asthmatics nonatopic...
Asthma is characterized by bronchial mucosal inflammation. Although allergen-induced activation of cells binding allergen-specific immunoglobulin E (IgE) through high-affinity receptors (Fc(epsilon)RI) believed to play some role in asthma, inappropriate synthesis total or IgE cannot be demonstrated ("intrinsic") patients despite the fact that nature inflammation similar atopic ("extrinsic") asthmatics. We have studied numbers and phenotype Fc(epsilon)RI-bearing biopsies from 12 10 nonatopic...
Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This particularly relevant since AR understood differently across European countries, as reflected by rhinitis-related search in Google Trends. study aims to assess co-medication regional Europe, using real-world data. We analysed 2015-2020 MASK-air® compared days under no medication, monotherapy the visual analogue scale (VAS) levels for overall symptoms ('VAS Global Symptoms')...
MASK-air
Adherence to rhinitis treatment has been insufficiently assessed. We aimed use data from the MASK-air mHealth app assess adherence oral antihistamines (OAH), intra-nasal corticosteroids (INCS) or azelastine-fluticasone in patients with allergic rhinitis. included regular European users self-reported and reporting at least 1 day of OAH, INCS azelastine-fluticasone. assessed weeks during which answered questionnaire on all days. restricted our analyses provided between January June, encompass...
The C-C chemokines RANTES and monocyte chemotactic protein-3 (MCP-3) are potent chemoattractants in vitro for eosinophils other cell types associated with allergic reactions. We tested the hypothesis that allergen-induced infiltration of eosinophils, T cells, macrophages skin atopic subjects is accompanied by appearance mRNA+ cells MCP-3. Cryostat sections were obtained from biopsies six 6, 24, 48 h after allergen challenge. Tissue was processed immunocytochemistry (ICC) situ hybridization...
Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with avoidance environmental triggers in alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen air density, relatively low temperature humidity, increased UV radiation at moderate induce several physiological immunological adaptation responses. include aeroallergens such as house dust mites...
Validated questionnaires are used to assess asthma control over the past 1-4 weeks from reporting. However, they do not adequately capture in patients with fluctuating symptoms. Using Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily score (e-DASTHMA).We MASK-air data (freely available users 27 countries) develop different scores asthma. Data-driven were based on symptoms reported by a visual analogue scale (VAS) self-reported...
Abstract Background In allergic rhinitis and asthma, adolescents young adult patients are likely to differ from older patients. We compared adolescents, adults on symptoms, control levels, medication adherence. Methods a cross‐sectional study (2015–2022), we assessed European users of the MASK‐air mHealth app three age groups: (13–18 years), (18–26 (>26 years). them their reported asthma use adherence treatment Allergy symptoms were by means visual analogue scales (VASs) or combined...
IL-13, like IL-4, induces up-regulation of vascular cell adhesion molecule-1 (VCAM-1) expression on human endothelial cells in vitro. This may contribute to local accumulation alpha4beta1+ inflammatory cells, such as eosinophils, macrophages, and T cells. We tested the hypothesis that allergic reactions vivo, IL-13 IL-4 are both involved VCAM-1/alpha4beta1-dependent recruitment Cryostat cutaneous sections from 13 atopic subjects taken 6, 24, 48 h after allergen challenge were processed for...
The COVID-19 pandemic has now affected around 190 million people worldwide, accounting for more than 4 confirmed deaths. Besides ongoing global vaccination, finding protective and therapeutic strategies is an urgent clinical need. SARS-CoV-2 mostly infects the host organism via respiratory system, requiring angiotensin-converting enzyme 2 (ACE2) transmembrane protease serine (TMPRSS2) to enter target cells. Therefore, these surface proteins are considered potential druggable targets....
Eosinophils synthesize and store various cytokines with potential autocrine activity. We hypothesized that eosinophils RANTES, a CC-chemokine potent eosinophil chemotactic Expression of RANTES mRNA in highly purified populations was detected by reverse transcription followed polymerase chain reaction analysis. In situ hybridization (ISH) 35S-labeled RANTES-specific riboprobes showed 6.8-10% peripheral blood obtained from atopic subjects expressed mRNA, increasing to 25% after incubation (16...