Mihaela Zidarn
A5075212241- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Delphi Technique in Research
- Health and Medical Studies
- Insect and Pesticide Research
- Healthcare and Venom Research
- Urticaria and Related Conditions
- Mast cells and histamine
- Pharmaceutical studies and practices
- Vitamin K Research Studies
- Nasal Surgery and Airway Studies
- Occupational exposure and asthma
- Immunotherapy and Immune Responses
- Health Systems, Economic Evaluations, Quality of Life
- Enzyme function and inhibition
- Nursing Diagnosis and Documentation
- Olfactory and Sensory Function Studies
- SARS-CoV-2 detection and testing
University Clinic of Pulmonary and Allergic Diseases Golnik
2016-2025
University of Ljubljana
2012-2025
Charité - Universitätsmedizin Berlin
2021
Sanofi (France)
2021
Takeda (Italy)
2021
Novartis (Ireland)
2021
ENT and Allergy
2021
Humboldt-Universität zu Berlin
2021
Angela Boškin Faculty of Health Care
2021
Medical University of Warsaw
2017
BM32 is a grass pollen allergy vaccine based on recombinant fusion proteins consisting of nonallergenic peptides from the IgE-binding sites 4 major allergens and hepatitis B preS protein.We sought to study safety clinical efficacy immunotherapy (allergen immunotherapy) with in patients pollen-induced rhinitis controlled asthma.A double-blind, placebo-controlled, multicenter allergen field was conducted for 2 seasons. After baseline season, subjects (n = 181) were randomized received 3...
Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This particularly relevant since AR understood differently across European countries, as reflected by rhinitis-related search in Google Trends. study aims to assess co-medication regional Europe, using real-world data. We analysed 2015-2020 MASK-air® compared days under no medication, monotherapy the visual analogue scale (VAS) levels for overall symptoms ('VAS Global Symptoms')...
MASK-air
Adherence to rhinitis treatment has been insufficiently assessed. We aimed use data from the MASK-air mHealth app assess adherence oral antihistamines (OAH), intra-nasal corticosteroids (INCS) or azelastine-fluticasone in patients with allergic rhinitis. included regular European users self-reported and reporting at least 1 day of OAH, INCS azelastine-fluticasone. assessed weeks during which answered questionnaire on all days. restricted our analyses provided between January June, encompass...
The strongest and best-documented risk factor for drug hypersensitivity (DH) is the history of a previous reaction. Accidental exposures to drugs may lead severe or even fatal reactions in sensitized patients. Preventable prescription errors are common. They often due inadequate medical poor assessment recurrence Proper documentation essential information doctor make sound therapeutic decision. European Network on Drug Allergy Interest Group Academy Clinical Immunology have formed task force...
Abstract Background In patients who require venom immunotherapy (VIT), there is a need to identify underlying mast cell (MC) disorders since these may affect the risk and severity of future sting reactions long‐term effectiveness VIT. Methods 1319 individuals with Hymenoptera allergy (HVA) needed VIT from referral centers in Slovenia, Austria, Croatia, Poland underwent examination for KIT p.D816V peripheral blood leukocytes (PBL) using highly sensitive PCR test tryptase genotyping by digital...
Previous reports suggest the usefulness of basophil activation testing (BAT) in Hymenoptera-allergic patients with negative venom-specific IgE antibodies. We sought to evaluate diagnostic utility this a routine clinical laboratory setting.Twenty-one anaphylactic reactions Hymenoptera sting (median grade III) and were routinely prospectively tested BAT.We able diagnose 81% (17 21) BAT 57% (12 intradermal skin testing. Three wasp venom-allergic showed positivity rVes v 5. Four (19%) for all...
Adverse systemic reactions (SRs) are more common in honeybee venom immunotherapy (VIT) than wasp VIT. Factors that might be associated with SRs during the VIT poorly understood.Our aim was to evaluate risk factors for build-up phase of immunotherapy.We included 93 patients who underwent ultra-rush The adverse and their severity compared various immunological (sIgE, tIgE, basophil CD63 response, baseline tryptase, skin tests), patient-specific (age, sex, cardiovascular conditions medications,...
Abstract Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. includes mHealth apps, offer the potential to redesign aspects of healthcare delivery. The capacity apps collect large amounts longitudinal, real‐time, real‐world data enables progression biomedical knowledge. Apps for rhinitis rhinosinusitis were searched in Google Play Apple App stores, via automatic market research tool recently developed using JavaScript. Over...
The delivery of vaccines plays a pivotal role in influencing the strength and longevity immune response controlling reactogenicity. Mucosal immunization, as compared to parenteral vaccination, could offer greater protection against respiratory infections while being less invasive. While oral vaccination has been presumed effective believed target mainly gastrointestinal tract, trans-buccal using mucoadhesive films (MAF) may allow targeted mucosa. Here we present an strategy for mucosal...
An important advantage of allergen immunotherapy as compared to pharmacotherapy for allergic rhinitis is the long-term effect that persists after completing immunotherapy. The mechanism sustained not completely understood.We conducted a 7-year study monitoring allergen-specific basophil response and serological markers in 20 subjects with moderate-to-severe grass pollen-allergic just before beginning up-dosing subcutaneous pollen immunotherapy, first season, 1-2 years completion 3-5...
Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., "real-world data"). We aimed to compare AR pharmacological on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) allergy symptom control considering the minimal important difference (MID) (iv) effect AIT. assessed MASK-air® app (May 2015-December 2020) by users...
Allergic rhinitis (AR) and asthma may affect health-related quality of life. However, national estimates on the life patients with AR or are lacking.
Hereditary angioedema (HAE) is a rare autosomal dominant disease characterized by swelling of the face, lips, tongue, larynx, genitalia, or extremities, with abdominal pain caused intra-abdominal edema. HAE mutations affecting C1 inhibitor gene, SERPING1, resulting in low levels (Type I HAE) normal ineffective II HAE). A nationwide survey identified nine unrelated families Slovenia, among whom 17 individuals from eight were recruited for genetic analyses. diagnosis was established presence...
Background Allergy to bee and wasp venom can lead life-threatening systemic reactions. The identification of the culprit species is important for allergen-specific immunotherapy. Objectives To determine a panel recombinant allergens which suitable or as allergen sources search molecular surrogates clinical severity sting Methods Sera from eighty-seven patients with detailed documentation their reaction (Mueller grade) who had been subjected titrated skin testing were analyzed wasp-specific...