Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. Since the influence vascular stressors prompts cross-reactivity with microbial human HSPD1 (HSP60), which results in degradation endothelium intimal infiltration by mononuclear cells, HSP60 viewed as key player autoimmune theory atherosclerosis. The aim study: present pilot study investigated whether tag SNP rs11682567 associated risk IS. Materials methods: DNA samples from 1176 unrelated Russian subjects...

HSPA8 is involved in many stroke-associated cellular processes, playing a pivotal role the protein quality control system. Here we report results of pilot study aimed at determining whether SNPs are linked to risk ischemic stroke (IS). DNA samples from 2139 Russians (888 IS patients and 1251 healthy controls) were genotyped for tagSNPs (rs1461496, rs10892958, rs1136141) gene using probe-based PCR. SNP rs10892958 was associated with an increased (risk allele G) smokers (OR = 1.37; 95% CI...

The aim of this study was to examine the role hereditary thrombophilia in development fetal growth retardation (FGR) population Central Russia.The case-control sample included 497 women third trimester pregnancy recruited during 2009-2013. participants were enrolled into two groups: patients with FGR (n = 250) and controls without 247). genotyped for four genetic markers thrombophilia: factor V Leiden (G > A FV, rs6025), prothrombin FII, rs1799963), VII FVII, rs6046), fibrinogen FI,...

To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663)A/G TNFR2 with development primary open angle glaucoma (POAG) among people in Central Russia.The study sample included 443 individuals, which 252 patients POAG and 191 individuals control group. Genotyping was performed using polymerase chain reaction. The distribution alleles genotypes studied DNA markers groups examined by 2×2 contingency tables χ2 Yates's correction for continuity...

The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in molecular basis essential hypertension (EH).A total 2160 unrelated Russian individuals comprising 1341 EH patients and 819 healthy controls were recruited into study. Seven common AHR single-nucleotide (SNPs) such as rs2066853, rs2292596, rs2228099, rs1048943, rs762551, rs1056836, rs1800566 genotyped by TaqMan-based allele discrimination...

Abstract The present study investigated a joint contribution of matrix metalloproteinases (MMPs) genes to ischemic stroke (IS) development and analyzed interactions between MMP genome‐wide associated loci for IS. A total 1288 unrelated Russians (600 IS patients 688 healthy individuals) from Central Russia were recruited the study. Genotyping seven single nucleotide polymorphisms (SNPs) (rs1799750, rs243865, rs3025058, rs11225395, rs17576, rs486055, rs2276109) eight done using Taq‐Man–based...

The purpose of this pilot study was to explore whether polymorphisms in genes encoding the catalytic (GCLC) and modifier (GCLM) subunits glutamate-cysteine ligase, a rate-limiting enzyme glutathione synthesis, play role development ischemic stroke (IS) extent brain damage. A total 1288 unrelated Russians, including 600 IS patients 688 age- sex-matched healthy subjects, were enrolled for study. Nine common single nucleotide (SNPs) GCLC GCLM genotyped using MassArray-4 system. SNP rs2301022...

The SERBP1 gene is a well-known regulator of SERPINE1 mRNA stability and progesterone signaling. However, the chaperone-like properties have recently been discovered. present pilot study investigated whether SNPs are associated with risk clinical manifestations ischemic stroke (IS). DNA samples from 2060 unrelated Russian subjects (869 IS patients 1191 healthy controls) were genotyped for 5 common SNPs—rs4655707, rs1058074, rs12561767, rs12566098, rs6702742 SERBP1—using probe-based PCR....

The unique chaperone-like properties of C19orf53, discovered in 2020 as a "hero" protein, make it an intriguing subject for research relation to ischemic stroke (IS). Our pilot study aimed investigate whether C19orf53 SNPs are associated with IS. DNA samples from 2138 Russian subjects (947 IS and 1308 controls) were genotyped 7

The present pilot study aimed to investigate whether common single nucleotide polymorphisms (SNPs) in the gene encoding glutathione S-transferase omega 1 (GSTO1), both individually and combination with variants of catalytic subunit glutamate cysteine ligase (GCLC) environmental risk factors, are associated psoriasis. research included a total 944 participants, comprising 474 individuals diagnosed psoriasis 470 healthy control subjects. Five SNPs GSTO1 gene—specifically, rs11191736,...

Gene encoding flavin-containing monooxygenase 3 (FMO3), a microsomal antioxidant defense enzyme, has been suggested to contribute essential hypertension (EH). The present study was designed investigate whether common functional polymorphism E158K (rs2266782) of the FMO3 gene is associated with EH susceptibility in Russian population. A total 2 995 unrelated subjects from Kursk (1 362 patients and 843 healthy controls) Belgorod (357 422 population regions Central Russia were recruited for...

Numerous studies demonstrated an importance of cytochrome P-450 epoxygenase pathway arachidonic acids metabolism for the pathogenesis essential hypertension (EH). The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), CYP2C19 (rs4244285) are associated with susceptibility EH in Russian population. A total 816 unrelated individuals comprising 425 patients 391...

Background: Ischemic stroke (IS) is the leading cause of death and disability worldwide. Chaperone proteins protect brain cells from ischemic damage by restoring structures damaged proteins. C9orf16 (also known as BBLN) belongs to class heat-resistant obscure (HERO) proteins, characterized ability stabilize various suppress neurotoxicity reduce proteotoxic stress. In this regard, it may play a potentially significant role in risk development clinical manifestations IS. The aim study: To...

: Recently identified Hero proteins, which possess chaperone-like functions, are promising candidates for research into atherosclerosis-related diseases, including ischemic stroke (IS).

Compromised defense against reactive oxygen species (ROS) is considered important in the pathogenesis of type 2 diabetes mellitus (T2DM); therefore, genes encoding antioxidant enzymes may contribute to disease susceptibility. This study investigated whether polymorphisms glutathione S-transferase M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) jointly risk T2DM.In all, 1120 unrelated Russian subjects (600 T2DM patients, 520 age- sex-matched healthy subjects), were recruited study. Genotyping was...

Ischemic stroke (IS) is one of the most serious cardiovascular events associated with high risk death or disability. The growing body evidence highlights molecular chaperones as especially important players in pathogenesis disease. Since six small proteins called "Hero" have been recently identified a novel class we aimed to evaluate whether SNP rs4644832

The present study was designed to investigate whether the susceptibility acute pancreatitis (AP) attributable polymorphism rs10273639 at PRSS1-PRSS2 locus is dependent on alcohol consumption and cigarette smoking.A total of 603 unrelated Russian individuals including 304 patients with physician-diagnosed AP 299 sex- age-matched healthy controls have been recruited for study. A (-408C>T) genotyped by TaqMan-based assay.A variant allele -408T (P = 0.003) genotypes -408CT plus TT 0.002) were...

Background: Arterial hypertension (AH) is the most common disease of cardiovascular system.Intracellular chemical and oxidative stress, which can be associated both with direct exposure to toxic xenobiotics their excessive activation during biotransformation, may lead endothelial dysfunction increased risk AH development.The aim study: To investigate association single nucleotide polymorphisms genes involved in biotransformation (rs1048943 CYP1A1, rs762551 CYP1A2, rs1056836 CYP1B1, rs1799930...