A5033923017- Vestibular and auditory disorders
- Visual perception and processing mechanisms
- Spaceflight effects on biology
- Hearing, Cochlea, Tinnitus, Genetics
- High Altitude and Hypoxia
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Neural dynamics and brain function
- Space Science and Extraterrestrial Life
- Functional Brain Connectivity Studies
- Tactile and Sensory Interactions
- Space Exploration and Technology
- Advanced Neuroimaging Techniques and Applications
- Mitochondrial Function and Pathology
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Hearing Loss and Rehabilitation
- Photoacoustic and Ultrasonic Imaging
- Anesthesia and Neurotoxicity Research
- Electromagnetic Fields and Biological Effects
- Cerebrospinal fluid and hydrocephalus
- Neuroscience of respiration and sleep
- Cerebrovascular and genetic disorders
- Multisensory perception and integration
- Heart Rate Variability and Autonomic Control
Ludwig-Maximilians-Universität München
2013-2024
LMU Klinikum
2019-2024
German Center for Lung Research
2016-2023
Bernstein Center for Computational Neuroscience Munich
2022
Munich Cluster for Systems Neurology
2013-2021
München Klinik
2020
Research Center of Neurology
2020
Johannes Gutenberg University Mainz
2010-2017
Chonbuk National University Hospital
2017
Jeonbuk National University
2017
A prerequisite for many eye tracking and video-oculography (VOG) methods is an accurate localization of the pupil. Several existing techniques face challenges in images with artifacts under naturalistic low-light conditions, e.g. highly dilated pupils. For first time, we propose to use a fully convolutional neural network (FCNN) segmentation whole pupil area, trained on 3946 VOG hand-annotated at our institute. We integrate FCNN into DeepVOG, along established method gaze estimation from...
Significance Long-duration spaceflight induces detrimental changes in human physiology due to microgravity. One example is a cephalic fluid shift. Here, we prospectively investigated the quantitative cerebrospinal (CSF) volume of brain ventricular regions space crew by means region interest, observer-independent analysis on structural MRI scans. scans were collected before mission, shortly after and 7 mo return Earth. We found significant increase lateral third ventricles at postflight trend...
Spaceflight causes persisting sensorimotor neuroplasticity and reversible gray matter morphological changes.
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these whether they equally affect crews different space agencies remain unknown. We used MRI analyze alterations occurring in perivascular spaces (PVS) NASA European Space Agency astronauts Roscosmos cosmonauts after a 6-mo on International Station (ISS). found increased volume basal ganglia...
Abstract Objective Patients who have had vestibular neuritis (VN) show a remarkable clinical improvement especially in gait and posture >6 months after disease onset. Methods Voxel‐based morphometry was used to detect the VN‐induced changes gray white matter by means of structural magnetic resonance imaging. Twenty‐two patients were compared an average 2.5 years onset VN healthy sex‐and age‐matched control group. Results Our analysis revealed that all signal intensity increases for medial...
Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue become a space-faring species, it is imperative that fully understand the occur in human body, including brain. In this study, present findings brain structural associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average six months aboard International Space Station (ISS) were scanned MRI scanner...
The prospect of continued manned space missions warrants an in-depth understanding how prolonged microgravity affects the human brain. Functional magnetic resonance imaging (fMRI) can pinpoint changes reflecting adaptive neuroplasticity across time. We acquired resting-state fMRI data cosmonauts before, shortly after, and eight months after spaceflight as a follow-up to assess global connectivity over Our results show persisting decreases in posterior cingulate cortex thalamus increases...
Abstract Background In functional imaging studies, the insular cortex ( IC ) has been identified as an essential part of processing a whole spectrum multimodal sensory input. However, there are no lesion studies including sufficient number patients, which would reinforce data obtained from healthy subjects. Such should examine how damage to affects perception. We chose acute stroke patients with lesions affecting in order fill this gap. Methods A comprehensive profiling by applying...
Little is known about the cortical organization of human vestibular information processing. Instead a dedicated primary cortex, distributed network regions across cortex respond to input. The aim this study characterize corticocortical and compare it established results in non-human primates. We collected high-resolution multi-shell diffusion-weighted (DWI) state-of-the-art resting-state functional MR images 29 right-handed normal subjects. Ten per hemisphere were predefined from previous...
Earlier functional imaging studies on visually induced self-motion perception (vection) disclosed a bilateral network of activations within primary and secondary visual cortex areas which was combined with signal decreases, i.e., deactivations, in multisensory vestibular areas. This finding led to the concept reciprocal inhibitory interaction between systems. In order define involved special aspects such as intensity duration perceived circular vection (CV) or amount head tilt, correlation...
In previous imaging studies, the posterior insular cortex (IC) was identified as an essential part for vestibular otolith perception and considered a core region of human cortical network. However, it is still unknown whether lesions exclusively restricted to IC suffice provoke signs dysfunction. Thus, present data aimed test patients with showed We studied 10 acute unilateral stroke which were tested dysfunction, such tilts subjective visual vertical, out 475 patients. None affecting...
Functional dizziness syndromes are among the most common diagnoses made in patients with chronic dizziness, but their underlying neural characteristics largely unknown. The aim of this neuroimaging study was to analyze disease-specific brain changes phobic postural vertigo (PPV).We measured morphology, task response, and functional connectivity 44 PPV healthy controls.The analyses revealed a relative structural increase regions prefrontal cortex associated thalamic projection zones as well...
Background In previous imaging studies the insular cortex (IC) has been identified as an essential part of processing a wide spectrum perception and sensorimotor integration. Yet, there are no systematic lesion in sufficient number patients examining whether vestibular interaction somatosensory signals take place IC. Methods We investigated acute stroke with lesions affecting IC order to fill this gap. detail, we explored signs tone imbalance such deviation subjective visual vertical (SVV)....
Abstract While structural network analysis consolidated the hypothesis of cerebral small vessel disease (SVD) being a disconnection syndrome, little is known about functional changes on level brain networks. In patients with genetically defined SVD (CADASIL, n = 41) and sporadic ( 46), we independently tested that networks change burden mediate effect cognitive performance, in particular slowing processing speed. We further determined test–retest reliability measures participating...
Background: Up to now, there are few systematic studies in a sufficient number of patients with lesions involving the insular cortex (IC) examining whether damage IC is directly related dysarthria. Thus, this first study applying modern voxel-lesion behaviour mapping (VLBM) aimed examine involved dysarthria – and if so which part involved. Methods: Twenty-five acute stroke affecting peri-insular region were investigated employing VLBM analysis. Results: Present data indicated that associated...
Functional dizziness comprises a class of disorders, including phobic postural vertigo (PPV), that cause vestibular symptoms in the absence structural organic origin. For this reason, functional brain mechanisms have been implicated these disorders.Here, network organization was investigated 17 PPV patients and 18 healthy controls (HCs) during magnetic resonance imaging with visual motion stimulus, data initially collected described by Popp et al. (2018). Graph theoretical measures (degree...