A5080189585- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and genetic disorders
- Bone and Joint Diseases
- Microbial metabolism and enzyme function
- Fatty Acid Research and Health
- Immune responses and vaccinations
- Advanced MRI Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Immune cells in cancer
- Atrial Fibrillation Management and Outcomes
Radboud University Medical Center
2018-2024
Radboud University Nijmegen
2018-2024
Ludwig-Maximilians-Universität München
2020
Medical University of Graz
2020
Munich Cluster for Systems Neurology
2020
German Center for Neurodegenerative Diseases
2020
University Medical Center Utrecht
2020
Utrecht University
2020
University Medical Center
2020
Background and Purpose— Cerebral small vessel disease (cSVD) is the major vascular cause of cognitive decline dementia. The pathogenesis cSVD remains largely unknown, although several studies suggest a role for systemic inflammation. In certain pathophysiological situations, monocytes can reprogram toward long-term proinflammatory phenotype, which has been termed trained immunity. We hypothesize that immunity contributes to progression cSVD. Methods— Individuals with mild-to-severe...
Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate hemorrhage in patients atrial fibrillation treated vitamin K antagonists, direct oral anticoagulants, antiplatelets, combination therapy (i.e. concurrent anticoagulant antiplatelet).
<h3>Objective</h3> To test the hypothesis that multi-shell diffusion models improve characterization of microstructural alterations in cerebral small vessel disease (SVD), we assessed associations with processing speed performance, longitudinal change, and reproducibility metrics. <h3>Methods</h3> We included 50 patients sporadic 59 genetically defined SVD (cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy [CADASIL]) cognitive testing standardized 3T MRI,...
To determine the contribution of acute infarcts, evidenced by diffusion-weighted imaging positive (DWI+) lesions, to progression white matter hyperintensities (WMH) and other cerebral small vessel disease (SVD) markers.We performed monthly 3T magnetic resonance (MRI) for 10 consecutive months in 54 elderly individuals with SVD. MRI included high-resolution multishell DWI, 3-dimensional fluid-attenuated inversion recovery, T1, susceptibility-weighted imaging. We determined DWI+ lesion...
To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role origin SVD markers on MRI.We included 503 from Radboud University Nijmegen Diffusion Tensor Magnetic Resonance Imaging Cohort (RUN DMC) study (mean age 65.6 years [SD 8.8], 56.5% male) 1.5T MRI 2006 and, if available, follow-up 2011 2015. We screened DWI scans (n = 1,152) for DWI+ lesions, assessed lesion evolution...
Abstract While structural network analysis consolidated the hypothesis of cerebral small vessel disease (SVD) being a disconnection syndrome, little is known about functional changes on level brain networks. In patients with genetically defined SVD (CADASIL, n = 41) and sporadic ( 46), we independently tested that networks change burden mediate effect cognitive performance, in particular slowing processing speed. We further determined test–retest reliability measures participating...
Neuropathology studies show a high prevalence of cortical microinfarcts (CMIs) in aging individuals, especially patients with cerebrovascular disease and dementia. However, most, are invisible on T1- T2-weighted magnetic resonance imaging (MRI), raising the question how to explain this mismatch. Studies small acute infarcts, detected diffusion-weighted (DWI), suggest that infarcts largest their phase reduce size thereafter. Therefore, we hypothesized subset CMI MRI can be phase. our...
Objective To determine whether the presence of diffusion-weighted imaging-positive (DWI+) lesions is associated with recurrent stroke after intracerebral haemorrhage (ICH). Methods The REstart or STop Antithrombotics Randomised Trial (RESTART) assessed effect restarting versus avoiding antiplatelet therapy ICH on major vascular events for up to 5 years. We rated DWI sequences MRI done before randomisation DWI+ lesion presence, masked outcome and use. Cox proportional hazards regression...
We characterize the associations of total cerebral small vessel disease (SVD) burden with brain structure, trajectories vascular risk factors, and cognitive functions in mid-to-late life. Participants were 623 community-dwelling adults from Whitehall II Imaging Sub-study multi-modal MRI (mean age 69.96, SD = 5.18, 79% men). used linear mixed-effects models to investigate SVD up 25-year retrospective performance. General modelling was concurrent grey matter (GM) density white (WM)...
Neuroimaging in older adults commonly reveals signs of cerebral small vessel disease (SVD). SVD is believed to be caused by chronic hypoperfusion based on animal models and longitudinal studies with inter-scan intervals years. Recent imaging evidence, however, suggests a role for acute ischaemia, as indicated incidental diffusion-weighted lesions (DWI+ lesions), the origin SVD. Furthermore, it becomes increasingly recognised that focal likely affect structure function brain areas remote from...
Background: The etiology of cerebral small vessel disease (SVD) remains elusive, though evidence is accumulating that inflammation contributes to its pathophysiology. We recently showed retrospectively pro-inflammatory monocytes are associated with the long-term progression white matter hyperintensities (WMHs). In this prospective high-frequency imaging study, we hypothesize incidence SVD coincides a monocyte phenotype. Methods: Individuals underwent monthly magnetic resonance (MRI) for 10...
Cerebral small vessel disease (SVD) is considered a disconnection syndrome, which can be quantified using structural brain network analysis obtained from diffusion MRI. Network demanding approach and the added benefit over simpler MRI largely unexplored in SVD. In this pre-registered study, we assessed clinical technical validity of two non-overlapping samples SVD patients RUN DMC study (n = 52 for exploration longitudinal n 105 validation). We compared connectome pipelines utilizing...
Background Small hyperintense lesions are found on diffusion-weighted imaging (DWI) in patients with sporadic small vessel disease (SVD). Their exact role SVD progression remains unclear due to their asymptomatic and transient nature. The main objective is investigate the of DWI+lesions radiological relationship clinical outcomes. Methods Participants were included from Radboud University Nijmegen Diffusion tensor MRI Cohort. assessed four time points over 14 years. Outcome measures...
Recent studies suggest that a subset of cortical microinfarcts may be identifiable on T2* but invisible T1 and T2 follow-up images. We aimed to investigate whether are associated with iron accumulation after the acute stage. The RUN DMC – InTENse study is serial MRI including individuals cerebral small vessel disease (SVD). 54 Participants underwent 10 monthly 3 T MRIs, diffusion-weighted imaging, quantitative R1 (=1/T1), R2 (=1/T2), R2* (=1/T2*) mapping, from which parameters within areas...
It is unclear why cerebral small vessel disease (SVD) leads to lacunar stroke in some and non-lobar intracerebral hemorrhage (ICH) others. We investigated differences MRI markers of SVD patients with or ICH.We included from two prospective cohort studies either (RUN DMC) ICH (FETCH). Differences (white matter hyperintensities [WMH], lacunes, microbleeds [CMB]) between groups were univariable tests; multivariable logistic regression analysis, adjusted for age, sex, vascular risk factors;...
The current study aimed to investigate whether diffusion-weighted imaging-positive (DWI+) lesions after acute intracerebral hemorrhage (ICH) are associated with underlying small vessel disease (SVD) or linked the ICH. We included patients ≥18 years spontaneous ICH confirmed on neuroimaging and performed 3T MRIs a median of 11 days (interquartile range [IQR] 6–43). DWI+ were assessed in relation hematoma (perihematomal vs. distant ipsilateral contralateral). Differences clinical...
Abstract We characterize the associations of total cerebral small vessel disease (SVD) burden with brain structure, trajectories vascular risk factors, and cognitive functions in mid-to-late life. Participants were 623 community-dwelling adults from Whitehall II Imaging Sub-study multi-modal MRI (mean age 69.96 SD=5.18, 79% men). used linear mixed-effects models to investigate SVD up 25-year retrospective performance. General modelling was concurrent grey matter (GM) density white (WM)...
In a cohort of 54 patients with sporadic cerebral small vessel disease, associations between diffusion MRI measures and processing speed were investigated both at low high b-values, revealing complementary microstructural information. Associations found by skeletonization confirmed an independent tractometry approach, which was further utilized to identify set association tracts associated cognition.