A5041168651- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Acute Ischemic Stroke Management
- Gastroesophageal reflux and treatments
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Retinal Development and Disorders
- Neurological Disease Mechanisms and Treatments
- Sparse and Compressive Sensing Techniques
- Fetal and Pediatric Neurological Disorders
German Center for Neurodegenerative Diseases
2019-2025
Ludwig-Maximilians-Universität München
2020
Radboud University Nijmegen
2020
Radboud University Medical Center
2020
University Medical Center
2020
Munich Cluster for Systems Neurology
2020
Medical University of Graz
2020
University of Bonn
2019
Abstract Visual impairment and retinal neurodegeneration are intrinsically connected both have been associated with cognitive brain atrophy, but the underlying mechanisms remain unclear. To investigate whether transneuronal degeneration is implicated, we systematically assessed relation between visual function retinal, pathway, hippocampal degeneration. We analyzed baseline data from 3316 eligible Rhineland Study participants acuity (VA), optical coherence tomography (OCT), magnetic...
<h3>Objective</h3> To test the hypothesis that multi-shell diffusion models improve characterization of microstructural alterations in cerebral small vessel disease (SVD), we assessed associations with processing speed performance, longitudinal change, and reproducibility metrics. <h3>Methods</h3> We included 50 patients sporadic 59 genetically defined SVD (cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy [CADASIL]) cognitive testing standardized 3T MRI,...
Abstract Retinal assessments have been discussed as biomarkers for brain atrophy. However, available studies did not investigate all retinal layers due to older technology, reported inconsistent results, or were based on small sample sizes. We included 2872 eligible participants of the Rhineland Study with data spectral domain–optical coherence tomography (SD–OCT) and magnetic resonance imaging (MRI). used multiple linear regression examine relationships between measurements volumetric...
<title>Abstract</title> Peak width of skeletonized mean diffusivity (PSMD) is an emerging automated diffusion imaging marker showing clinically relevant changes in cerebral small vessel disease (cSVD), a leading cause stroke and dementia with no mechanism-based treatment. We conducted genome-wide association study PSMD 58,403 participants from 24 population-based cohorts (89% European, 10% East-Asian, 1% African-American), identifying 31 independent common variant associations. Additionally,...
Plasma neurofilament light chain (NfL) level is a sensitive yet aspecific marker of neurodegeneration. Its neuroanatomical and functional correlates in the general population are not fully elucidated. We thus assessed how brain's macrostructures microstructures cognitive function related to plasma NfL levels cognitively unimpaired adults over wide age range. Our analyses were based on cross-sectional data from Rhineland Study, community-based prospective cohort study. This study includes...
Abstract Diffusion-weighted magnetic resonance imaging (dMRI) permits a detailed in-vivo analysis of neuroanatomical microstructure, invaluable for clinical and population studies. However, many measurements with different diffusion-encoding directions possibly b-values are necessary to infer the underlying tissue microstructure within voxels accurately. Two challenges particularly limit utility dMRI: long acquisition times feasible scans only few directional measurements, heterogeneity...
Abstract Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker cSVD in older age, were recently shown to be significantly associated with (WM) microstructure on diffusion tensor imaging (signal-based) young adults. To provide new insights into these early changes WM their relation cSVD, we sought explore genetic underpinnings cutting-edge tissue-based markers across adult lifespan....
In diffusion MRI, dropout refers to a strong attenuation of the measured signal that is caused by bulk motion during encoding. When left uncorrected, will be erroneously interpreted as high diffusivity in affected direction. We present method automatically detect dropout, and replace measurements with imputed values.Signal detected deriving an outlier score from simple harmonic oscillator-based reconstruction estimation (SHORE) fit all measurements. The defined are substantially lower than...
Abstract Reports linking proton pump inhibitors (PPIs) with cognition and dementia show conflicting results, limited evidence on underlying biological mechanisms. However, existing studies did not investigate brain microstructure, which could provide valuable insights into early structural changes indicative of cognitive decline. Analyses were based cross-sectional baseline data from the Rhineland Study ( n = 7,465; mean age 55.3 ± 13.7 years, range 30–95 56.5% women). Using multivariate...
To improve the quality of mean apparent propagator (MAP) reconstruction from a limited number q-space samples.We implement an ℓ1 -regularised MAP (MAPL1) to consider higher order basis functions and fit without increasing samples. We compare MAPL1 with least-squares optimization subject non-negativity (MAP), Laplacian-regularized (MAPL). use simulations crossing fibers compute normalized squared error (NMSE) Pearson's correlation coefficient evaluate in q-space. also coefficient-based...
Abstract Background Neuroimaging plays an essential role in epidemiological studies and a special focus is directed towards the employment of versatile MRI acquisition processing. The proposed multi‐purpose protocol was designed for large‐scale long‐term population neuroimaging includes structural, diffusion‐weighted, functional modalities. It directly links extensive set contrasts with fully automated data processing pipelines quality assurance image‐derived phenotypes. Method largely based...
To compare different q-space reconstruction methods for undersampled diffusion spectrum imaging data.We compared the quality of three methods: Mean Apparent Propagator (MAP); Compressed Sensing using Identity (CSI) and Dictionary (CSD) with simulated data in vivo acquisitions. We used retrospective undersampling so that fully sampled could be as ground truth. normalized mean squared error (NMSE) Pearson's correlation coefficient indices. Additionally, we evaluated two propagator-based...
Abstract Background Neurofilament light (NfL) protein level is considered a non‐specific marker of neurodegeneration. NfL levels have been associated with established, non‐blood based neurodegenerative markers, including cognitive performance and reduced brain volume. However, most studies were small (N<300), compared in patients (MCI, Alzheimer’s disease) those healthy controls. We investigated to what extent are MRI measures volume microstructure, large non‐demented population‐based...
Abstract Background Neuroimaging plays an essential role in epidemiological studies and a special focus is directed towards the employment of versatile MRI acquisition processing. The proposed multi‐purpose protocol was designed for large‐scale long‐term population neuroimaging includes structural, diffusion‐weighted, functional modalities. It directly links extensive set contrasts with fully automated data processing pipelines quality assurance image‐derived phenotypes. Method largely based...
Abstract Background White matter (WM) integrity declines with age and is affected by neurodegenerative diseases. Physical activity promotes neuronal health in animals, associated WM microstructure metrics humans. However, previous diffusion tensor imaging (DTI) studies were limited small sample sizes subjective questionnaire‐based physical assessments. Moreover, recently introduced neurite orientation dispersion density (NODDI) may offer complementary insights. Therefore, we examined the...
Abstract Purpose: The aim of the present study was to evaluate potential electrophysiological changes after autologous translocation choroid and retinal pigment epithelium for subfoveal choroidal neovascularisation in patients with age‐related macular degeneration. Methods: A consecutive series 20 suffering from secondary degeneration underwent tranlocation ERG recorded one day prior surgery no earlier than 4 weeks silicone oil removal. Results: amplitudes were significantly reduced surgery....
Abstract Background Cerebral small vessel disease (cSVD) is a leading cause of vascular cognitive impairment and dementia. Mounting evidence suggests that early life factors contribute to cSVD. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI‐marker cSVD in older age, were recently found show strong associations with microstructure on diffusion tensor imaging (DTI) already young adults their twenties. Here we aimed use multi‐shell further explore genetic...