Plasma neurofilament light chain (NfL) level is a sensitive yet aspecific marker of neurodegeneration. Its neuroanatomical and functional correlates in the general population are not fully elucidated. We thus assessed how brain's macrostructures microstructures cognitive function related to plasma NfL levels cognitively unimpaired adults over wide age range. Our analyses were based on cross-sectional data from Rhineland Study, community-based prospective cohort study. This study includes...

Introduction Detecting early pathological cognitive decline is critical for dementia and aging-related research clinical diagnostics. Rey's Auditory Verbal Learning Test (AVLT) commonly used to measure episodic verbal memory. The test requires participants learn a list of 15 words over several trials. Since multiple testing often required detect decline, but repeating the same can bias results, we developed 10 German AVLT word lists.Method We randomly assigned lists 4,000 (aged 30–94 years)...

Impaired speech-in-noise perception affects individuals' daily lives and is a frequent symptom of age-related hearing loss, which common disabling condition health concern in aging populations. The relative impact sensitivity loss different cognitive functions on not well understood. We aimed to assess what extent were associated with sentence-in-noise performance across the adult lifespan.This study based data 2585 participants Rhineland Study, German community-based cohort persons age 30...

To identify cognitive measures that may be particularly sensitive to early decline in preclinical Alzheimer's disease (AD), we investigated the relation between genetic risk for AD and task performance a large population-based cohort study. We measured on memory, processing speed, executive function, crystallized intelligence eye movement tasks 5182 participants of Rhineland Study, aged 30 95 years. quantified by creating three weighted polygenic scores (PRS) based genome-wide significant...

Abstract Background Spermidine is the most abundant polyamine in human body, but its intracellular concentrations decrease with ageing. supplementation reportedly protected against age‐related changes cognition and brain structures fruit flies (Gupta et al, 2013), increased memory performance older adults (Wirth 2018). However, effects of dietary spermidine intake on brain‐related outcomes are unclear. Therefore, we evaluated whether how cross‐sectionally associated cognitive function a...

Abstract Background Food systems play a major role in both human and planetary health. In 2019, the EAT‐Lancet Commission proposed universal, healthy reference diet, intending to improve environmental sustainability prevent non‐communicable diseases (Willet et al, 2019). Adherence diet (ELR‐diet) has been previously associated with lower cardiometabolic mortality risk (Knuppel 2019; Stubbendorff 2022). However, effects of ELR‐diet on brain‐related outcomes remain largely unexplored....

Schizophrenia is a heterogeneous disorder with substantial heritability. The use of endophenotypes may help clarify its aetiology. Measures from the smooth pursuit and antisaccade eye movement tasks have been identified as for schizophrenia in twin family studies. However, genetic basis overlap between these oculomotor markers largely unknown. Here, we tested whether polygenic risk scores (PRS) were associated performance general population.Analyses based on data 2956 participants (aged...

We introduce a new and time-efficient memory-encoding paradigm for functional magnetic resonance imaging (fMRI). This is optimized mapping multiple contrasts using mixed design, auditory (environmental/vocal) visual (scene/face) stimuli. demonstrate that the evokes robust neuronal activity in typical sensory memory networks. were able to detect sensory-specific encoding activities cortices. Also, we detected stimulus-selective activation environmental-, voice-, scene-, face-selective brain...

Abstract Background Neurofilament light (NfL) protein level is considered a non‐specific marker of neurodegeneration. NfL levels have been associated with established, non‐blood based neurodegenerative markers, including cognitive performance and reduced brain volume. However, most studies were small (N<300), compared in patients (MCI, Alzheimer’s disease) those healthy controls. We investigated to what extent are MRI measures volume microstructure, large non‐demented population‐based...

Recently, several large-scale studies employed task-based functional magnetic resonance imaging (fMRI) to map brain activity in a general population. These population are not motived by one single hypothesis, but acquire fMRI data the context of cognitive functions, lifestyle, health and biomarkers. Yet, most conventional task paradigms optimized for question unsuitable under high time-pressure. Here, we propose highly efficient task-paradigm mapping multisensory memory-related (<10 min)....

Recently, several large-scale studies employed task-based functional magnetic resonance imaging (fMRI) to map brain activity in a general population. These population are not motived by one single hypothesis, but acquire fMRI data the context of cognitive functions, lifestyle, health and biomarkers. Yet, most conventional task paradigms optimized for question unsuitable under high time-pressure. Here, we propose highly efficient task-paradigm mapping multisensory memory-related (<10 min)....