A5102972140- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Treatment of Major Depression
- Neurological and metabolic disorders
- Stress Responses and Cortisol
- Transcranial Magnetic Stimulation Studies
- Neuroscience of respiration and sleep
- Obsessive-Compulsive Spectrum Disorders
- Face Recognition and Perception
- Cannabis and Cannabinoid Research
- Electroconvulsive Therapy Studies
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
German Center for Neurodegenerative Diseases
2020-2025
TU Dresden
2011-2023
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2019
National Center for Geriatrics and Gerontology
2007
Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of individuals. In this work we propose a fast accurate deep learning based neuroimaging pipeline for the automated processing structural human brain MRI scans, replicating FreeSurfer's anatomical segmentation including surface reconstruction cortical parcellation. To end, introduce an advanced architecture...
Biomarkers useful for the predementia stages of Alzheimer's disease are needed. Electroencephalography and magnetoencephalography (MEG) expected to provide potential biomarker candidates evaluating disease. However, physiological relevance EEG/MEG signal changes their role in pathophysiological processes such as amyloid-β deposition neurodegeneration need be elucidated. We evaluated 28 individuals with mild cognitive impairment 38 cognitively normal individuals, all whom were further...
Insufficient default mode network (DMN) suppression was linked to increased rumination in symptomatic Major Depressive Disorder (MDD). Since is known predict relapse and a more severe course of MDD, we hypothesized that similar DMN alterations might also exist during full remission MDD (rMDD), condition be associated with rates specifically patients adolescent onset. Within cross-sectional functional magnetic resonance imaging study activation connectivity (FC) were investigated 120 adults...
Amyloid-β (Aβ) deposition is known to starts decades before the onset of clinical symptoms Alzheimer's disease (AD), however, detailed pathophysiological processes underlying this preclinical period are not well understood. This study aimed investigate functional network alterations in cognitively intact elderly individuals at risk for AD, and assessed association between these changes Aβ deposition, glucose metabolism, brain structure. Forty-five normal subjects, who were classified into...
Abstract Previous studies have reported alterations in cortical thickness autism. However, few included enough autistic females to determine if there are sex specific differences structure This longitudinal study aimed investigate and trajectory of thinning across childhood. Participants 290 (88 females) 139 nonautistic (60 individuals assessed at up 4 timepoints spanning ~2–13 years age (918 total MRI timepoints). Estimates early late childhood as well the were modeled using spatiotemporal...
Hippocampal volume loss has been related to chronic stress as well genetic factors. Although and environmental variables affecting hippocampal have extensively studied mental illness, limited evidence is available with respect G × E interactions on volume. The present MRI study investigated interaction effects between three well-studied functional variants (COMT Val158Met, BDNF Val66Met, 5-HTTLPR) associated a measure of adversity (life events questionnaire) in large sample healthy humans...
Abstract Regulation of emotions is necessary for successful attainment short-term and long-term goals. However, over-regulation may also have its costs. In anorexia nervosa (AN), forgoing food intake despite emaciation endocrine signals that promote eating an example “too much” self-control. Here we investigated whether voluntary emotion regulation in AN patients comes with associated disorder-relevant Thirty-five acute thirty-five age-matched healthy controls (HCs) performed established...
Psychopathy is characterized by severe deficits in emotion processing and empathy. These emotional might not only affect the feeling of own emotions, but also understanding others' mental states. The present study aims on identifying neurobiological correlates social-cognitive related alterations psychopathy.We applied a paradigm for investigation face processing, recognition, affective Theory Mind (ToM) to 11 imprisoned psychopaths 18 healthy controls. Functional magnetic resonance imaging...
Abstract Metabolic syndrome (MetS) is a major public health burden worldwide and associated with brain abnormalities. Although insulin resistance considered pivotal feature of MetS, its role in the pathogenesis MetS‐related alterations general population unclear. Therefore, 973 participants (mean age 52.5 years) population‐based Rhineland Study, we assessed morphology relation to MetS resistance, evaluated what extent pattern structural changes seen overlap those resistance. Cortical...
Background It is known that eyes-open (EO) and eyes-closed (EC) conditions invoke different organizations of brain functional networks, such as sensorimotor, attention, salience networks in healthy participants. Functional connectivity (FC) extracted from resting-state magnetic resonance imaging data, under either EO or EC conditions, has been widely applied to explore the neural substrates Alzheimer's disease (AD). However, impact eye on FC within AD continuum remains not fully understood....
The choice of a meaningful baseline condition is crucial issue for each experimental design. In the case cognitive emotion regulation, it common to either let participants passively view emotional stimuli without any further specific instructions or instruct them actively attend and permit arising emotions, contrast one these conditions with regulation condition. While “view” strategy can be assumed allow more spontaneous response, “permit” may result in pronounced affective response. As...
Abstract A common and mostly effective emotion regulation strategy is reappraisal. During reappraisal, activity in cognitive control brain regions increases associated with responding (e.g., the amygdala) diminishes. Immediately after it has been observed that amygdala again, which might reflect a paradoxical aftereffect. While there extensive empirical evidence for these neural correlates of regulation, only few studies targeted association individual differences personality traits. The aim...
In the electroencephalogram (EEG), early anticipatory processes are accompanied by a slow negative potential, initial contingent variation (iCNV), occurring between 500 and 1500 ms after cue onset over prefrontal cortical regions in tasks with cue-target intervals of about 3 s or longer. However, temporal sequence distributed activity contributing to iCNV generation remains unclear. During generation, selectively enhanced low-beta has been reported. Here we studied order activation foci...
The Implicit Association Test (IAT) is a widely used latency-based categorization task that indirectly measures the strength of automatic associations between target and attribute concepts. So far, little known about perceptual cognitive processes underlying personality IATs. Thus, present study examined event-related potential indices during execution an IAT measuring neuroticism (N = 70). effect was strongly modulated by P1 component indicating early facilitation relevant visual input...
Background The serotonin transporter (5-HTT) is abundantly expressed in humans by the gene SLC6A4 and removes (5-HT) from extracellular space. A blood-brain relationship between platelet synaptosomal 5-HT reuptake has been suggested, but it unknown today, if uptake can predict neural activation of human brain networks that are known to be under serotonergic influence. Methods functional magnetic resonance study was performed 48 healthy subjects maximal velocity (Vmax) assessed blood...
The hippocampus is one of the most studied neuroanatomical structures due to its involvement in attention, learning, and memory as well atrophy ageing, neurological, psychiatric diseases. Hippocampal shape changes, however, are complex cannot be fully characterized by a single summary metric such hippocampal volume determined from MR images. In this work, we propose an automated, geometry-based approach for unfolding, point-wise correspondence, local analysis features thickness curvature....
The neuroimage analysis community has neglected the automated segmentation of olfactory bulb (OB) despite its crucial role in function. lack an automatic processing method for OB can be explained by challenging properties (small size, location, and poor visibility on traditional MRI scans). Nonetheless, recent advances acquisition techniques resolution have allowed raters to generate more reliable manual annotations. Furthermore, high accuracy deep learning methods solving semantic problems...
Across various axis-1 disorders, the severity of dissociative symptoms is significantly related to a history childhood traumatization. Thus, question arises if coping with trauma leads neural adaptations that enhance frequency processing during adulthood. The aim two reported studies therefore was identify and replicate gray matter alterations associated dissociation.In first study, whole-brain MRI data were acquired for 22 female in-patients trauma-spectrum disorders severe trauma....
Emotion regulation is an indispensable part of mental health and adaptive behavior. Research into emotion processes has largely focused on the concurrent effects volitional regulation. However, there scarce evidence considering post-regulatory with regard to neural mechanisms emotional experiences. Therefore, we compared cognitive at different (immediate, short- long-term) time intervals. In fMRI study N = 46 (N 30 re-exposure) young healthy adults, neuronal responses negative neutral...
Emotion regulation is an indispensable part of mental health and adaptive behavior. Research into emotion processes has largely focused on the concurrent effects volitional regulation. However, there scarce evidence considering post-regulatory with regard to neural mechanisms emotional experiences. Therefore, we compared cognitive at different (immediate, short- long-term) time intervals. In fMRI study N=46 (N=30 re-exposure) young healthy adults, neuronal responses negative neutral pictures...
Abstract Hippocampal volumetry is an essential tool in researching and diagnosing mesial temporal lobe epilepsy (mTLE). However, it has a limited ability to detect subtle alterations hippocampal morphometry. Here, we establish apply novel geometry‐based that enables point‐wise morphometric analysis based on intrinsic coordinate system of the hippocampus. We hypothesized this uncovers structural not measurable by volumetry, but associated with histological underpinnings neuropsychological...