A5075915105- Eating Disorders and Behaviors
- Behavioral Health and Interventions
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Obesity, Physical Activity, Diet
- Impact of Technology on Adolescents
- Regulation of Appetite and Obesity
- Mental Health Research Topics
- Child Nutrition and Feeding Issues
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
- Humor Studies and Applications
- Neural and Behavioral Psychology Studies
- Child Development and Digital Technology
- Animal health and immunology
- Xenotransplantation and immune response
- Adipose Tissue and Metabolism
- Hair Growth and Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Veterinary Medicine and Surgery
- Obesity and Health Practices
- Identity, Memory, and Therapy
- Cardiovascular Disease and Adiposity
TU Dresden
2016-2025
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2013-2023
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie
2013-2023
Karolinska Institutet
2021
University Hospital Carl Gustav Carus
2013-2020
University of Freiburg
2020
Athinoula A. Martinos Center for Biomedical Imaging
2015-2016
Massachusetts General Hospital
2015-2016
Harvard University
2015-2016
Mind Research Network
2016
Individuals with anorexia nervosa are thought to exert excessive self-control inhibit primary drives.This study used functional MRI (fMRI) interrogate interactions between the neural correlates of cognitive control and motivational processes in brain reward system during anticipation monetary reward-related feedback. In order avoid confounding effects undernutrition, we studied female participants recovered from closely matched healthy controls. The fMRI analysis (including node-to-node...
The etiology of anorexia nervosa (AN) is poorly understood. Results from functional brain imaging studies investigating the neural profile AN using cognitive and emotional task paradigms are difficult to reconcile. Task-related often require a high level compliance can only partially explore distributed nature complexity function. In this study, resting state connectivity was used investigate well-characterized networks potentially relevant understand mechanisms underlying symptomatology AN....
Background. Patients with anorexia nervosa (AN) are characterized by a very low body weight but readily give up immediate rewards (food) for long-term goals (slim figure), which might indicate an unusual level of self-control. This everyday clinical observation may be quantifiable in the framework anticipation-discounting dilemma. Method. Using cross-sectional design, this study compared capacity to delay reward 34 patients suffering from acute AN (acAN), 33 weight-recovered (recAN) and 54...
Abstract Objective For adolescents, DSM‐5 differentiates anorexia nervosa (AN) and atypical AN with the 5th BMI‐centile‐for‐age. We hypothesized that diagnostic weight cut‐off yields (i) lower loss in (ii) discrepant premorbid BMI distributions between two disorders. Prior studies demonstrate predicts admission patients AN. explore these relationships Method Based on BMI‐centile < or ≥5th, participants included 411 female adolescent inpatients 49 from our registry study. Regression...
Abstract The neural underpinnings of anorexia nervosa (AN) are poorly understood. Results from existing functional brain imaging studies using disorder‐relevant food‐ or body‐stimuli have been heterogeneous and may be biased due to varying compliance strategies the participants. In this study, resting state connectivity was used. To explore distributed nature complexity function we characterized network patterns in patients with acute AN. Thirty‐five unmedicated female AN 35 closely matched...
Abstract Regulation of emotions is necessary for successful attainment short-term and long-term goals. However, over-regulation may also have its costs. In anorexia nervosa (AN), forgoing food intake despite emaciation endocrine signals that promote eating an example “too much” self-control. Here we investigated whether voluntary emotion regulation in AN patients comes with associated disorder-relevant Thirty-five acute thirty-five age-matched healthy controls (HCs) performed established...
Theoretical models and recent advances in the treatment of anorexia nervosa (AN) have increasingly focused on role alterations processing regulation emotions. To date, however, our understanding these changes is still limited reports emotional dysregulation AN been based largely self-report data, there a relative lack objective experimental evidence or neurobiological data. The current functional magnetic resonance imaging (fMRI) study investigated hemodynamic correlates passive viewing...
Prior research has investigated whether the capacity of individuals with anorexia nervosa (AN) to forgo food rewards in their pursuit thinness may manifest as more delayed gratification delay discounting tasks, but results have been mixed. In a previous study examining mouse-cursor movement trajectories during task, underweight patients AN made similar decisions relative healthy controls, displayed stable levels decision-making conflict. Here, we employed exact same methods test these...
Abstract Patients with anorexia nervosa (AN) are characterised by increased self-control, cognitive rigidity and impairments in set-shifting, but the underlying neural mechanisms poorly understood. Here we used functional magnetic resonance imaging (fMRI) to elucidate correlates of behavioural adaptation changes reward contingencies young acutely ill AN patients. Thirty-six adolescent/young adult, non-chronic female patients 36 age-matched healthy females completed a well-established...
<h3>Background:</h3> We have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and default mode (DMN) patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC recovered from nervosa to examine whether abnormalities are a state or trait marker of disease. To extend understanding nervosa, also estimated between large-scale networks. <h3>Methods:</h3> Girls women pair-wise, age- sex-matched...
Patients with anorexia nervosa forgo eating despite emaciation and severe health consequences. Such dysfunctional decision-making might be explained by an excessive level of self-control, alterations in homeostatic hedonic regulation, or interplay between these processes. We aimed to understand value-based its association the gut hormone ghrelin. Besides function, ghrelin has been implicated regulation appetite reward via modulation phasic dopamine signalling.In a cross-sectional design, we...
Atrophic brain changes in acute anorexia nervosa (AN) are often visible to the naked eye on computed tomography or magnetic resonance imaging scans, but it remains unclear what is driving these effects. In neurological diseases, neurofilament light (NF-L) and tau protein have been linked axonal damage. Glial fibrillary acidic (GFAP) has associated with astroglial injury. an attempt shed new factors potentially underlying past findings of structural alterations AN, current study investigated...
Individuals with anorexia nervosa (AN) are thought to engage in excessive amounts of self-control, which may contribute disorder development and maintenance. This "overcontrol" explain previous findings increased activity connectivity frontal brain regions involved top-down control functions response diverse stimuli including emotionally salient visual food stimuli. However, these observations were made largely tasks demanding explicit stimulus processing. Given the omnipresence cues their...
BackgroundEpigenetic variation in the serotonin transporter gene (SLC6A4) has been shown to modulate functioning of brain circuitry associated with salience network (SN) and thereby may heighten risk for mental illness.This study is first test this epigenetic-brain-behavior pathway patients anorexia nervosa (AN). MethodsResting state functional connectivity (rsFC) data blood samples were obtained from 55 acutely underweight female AN age-matched healthy controls (HC).Imaging was decomposed...
The amygdala is a subcortical limbic structure consisting of histologically and functionally distinct subregions. New automated structural magnetic resonance imaging (MRI) segmentation tools facilitate the in vivo study individual nuclei clinical populations such as patients with anorexia nervosa (AN) who show symptoms indicative dysregulation. This first to investigate volumes AN, their relationships leptin, key indicator AN-related neuroendocrine alterations, further measures.T1-weighted...
A massive but reversible reduction of cortical thickness and subcortical gray matter (GM) volumes in Anorexia Nervosa (AN) has been recently reported. However, the literature on alterations white (WM) volume microstructure changes both acutely underweight AN (acAN) after recovery (recAN) is sparse results are inconclusive. Here, T1-weighted diffusion-weighted MRI data a sizable sample young medication-free acAN (n = 35), recAN 32), age-matched female healthy controls (HC, n 62) were...