A5026208589- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Psychopathy, Forensic Psychiatry, Sexual Offending
- EEG and Brain-Computer Interfaces
- SARS-CoV-2 detection and testing
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Eating Disorders and Behaviors
- SARS-CoV-2 and COVID-19 Research
- Child and Adolescent Psychosocial and Emotional Development
- Alzheimer's disease research and treatments
- Child Abuse and Trauma
- Attachment and Relationship Dynamics
- COVID-19 Clinical Research Studies
- Mindfulness and Compassion Interventions
- Parvovirus B19 Infection Studies
- Personality Disorders and Psychopathology
- Health, Environment, Cognitive Aging
- Cytomegalovirus and herpesvirus research
- Dementia and Cognitive Impairment Research
- Viral Infections and Vectors
- Heart Rate Variability and Autonomic Control
Euroimmun Medizinische Labordiagnostika (Germany)
2019-2025
Oulu University Hospital
2018-2022
University of Oulu
2018-2022
Leibniz Institute for Neurobiology
2014-2021
Otto-von-Guericke University Magdeburg
2015-2019
Cognitive Neuroimaging Lab
2019
University of Tübingen
2017
Massachusetts General Hospital
2015
Technische Universität Dresden
2015
Center for Behavioral Brain Sciences
2014-2015
The topic of investigating how mindfulness meditation training can have antidepressant effects via plastic changes in both resting state and brain activity is important the rapidly emerging field neuroplasticity. In present study, we used a longitudinal design fMRI before after 40 days 13 novices. After training, compared differences network connectivity between rest using common functional methods. Interregional methods were paired with local measures such as Regional Homogeneity. As...
The physiological underpinnings of the necessity sleep remain uncertain. Recent evidence suggests that increases convection cerebrospinal fluid (CSF) and promotes export interstitial solutes, thus providing a framework to explain why all vertebrate species require sleep. Cardiovascular, respiratory vasomotor brain pulsations have each been shown drive CSF flow along perivascular spaces, yet it is unknown how such may change during in humans. To investigate these pulsation phenomena relation...
Neurobehavioral models of pedophilia and child sexual offending suggest a pattern temporal in particular prefrontal disturbances leading to inappropriate behavioral control subsequently an increased propensity sexually offend against children. However, clear empirical evidence for such mechanisms is still missing. Using go/nogo paradigm combination with functional magnetic resonance imaging (fMRI) we compared performance neural response patterns among three groups men matched age IQ:...
Low image sampling rates used in resting state functional magnetic resonance imaging (rs-fMRI) may cause aliasing of the cardiorespiratory pulsations over very low frequency (VLF) BOLD signal fluctuations which reflects to connectivity (FC). In this study, we examine effect rate on currently rs-fMRI FC metrics. Ultra-fast fMRI encephalography (MREG) data, sampled with TR 0.1 s, was downsampled different subsampled repetition times (sTR, range 0.3-3 s) for comparisons. Echo planar k-space (TR...
Abstract Increasing neuroimaging evidence suggests that mindfulness meditation expertise is related to different functional and structural configurations of the default mode network (DMN), salience (SN) executive at rest. However, longitudinal studies observing resting plasticity effects in brains novices who started practice are scarce generally one dimension, such as or effects. The purpose this study was investigate brain changes (e.g. DMN) after 40 days training set these context...
In monocentric studies, patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia exhibited alterations of functional cortical connectivity in resting-state MRI (rs-fMRI) analyses. Multicenter studies provide access to large sample sizes, but rs-fMRI may be particularly sensitive multiscanner effects. We used data from five centers the "German initiative for diagnostic biomarkers" (psymri.org), comprising 367 cases, including AD patients, MCI healthy older controls,...
Abstract The neural underpinnings of anorexia nervosa (AN) are poorly understood. Results from existing functional brain imaging studies using disorder‐relevant food‐ or body‐stimuli have been heterogeneous and may be biased due to varying compliance strategies the participants. In this study, resting state connectivity was used. To explore distributed nature complexity function we characterized network patterns in patients with acute AN. Thirty‐five unmedicated female AN 35 closely matched...
Previous resting-state functional connectivity studies in patients with anorexia nervosa used independent component analysis or seed-based to probe specific brain networks. Instead, modelling the entire as a complex network allows determination of graph-theoretical metrics, which describe global and local properties how networks are organized they interact.To determine differences between female acute pairwise matched healthy controls, we fMRI computed well-established graph metrics across...
The large number of multicollinear regional features that are provided by resting state (rs) fMRI data requires robust feature selection to uncover consistent networks functional disconnection in Alzheimer's disease (AD). Here, we compared elastic net regularized and classical stepwise logistic regression respect consistency diagnostic accuracy using rs-fMRI from four centers the "German resting-state initiative for biomarkers" (psymri.org), comprising 53 AD patients 118 age sex matched...
Abstract Objectives During the current pandemic, antibody testing based on venous serum helps to determine whether tested person has been previously infected with SARS-CoV-2. Alternatively, capillary blood can be taken via a finger prick (dried spots, DBS). In this study, paired DBS and venipuncture samples were using two serological assays evaluate usability of for detection anti-SARS-CoV-2 antibodies. Methods Paired collected from 389 volunteers, whom 75 had recent PCR-confirmed SARS-CoV-2...
Abstract Resting‐state fMRI studies have gained widespread use in exploratory of neuropsychiatric disorders. Graph metrics derived from whole brain functional connectivity been used to reveal disease‐related variations many disorders including major depression (MDD). These techniques show promise developing diagnostics for these often difficult identify However, the analysis resting‐state datasets is increasingly beset by a myriad approaches and methods, each with underlying assumptions....
Epilepsy causes measurable irregularity over a range of brain signal frequencies, as well autonomic nervous system functions that modulate heart and respiratory rate variability. Imaging dynamic neuronal signals utilizing simultaneously acquired ultra-fast 10 Hz magnetic resonance encephalography (MREG), direct current electroencephalography (DC-EEG), near-infrared spectroscopy (NIRS) can provide more comprehensive picture human function. Spectral entropy (SE) is nonlinear method to...
Abstract Determination of antibodies against ToRCH antigens at the beginning pregnancy allows assessment both maternal immune status and risks to an adverse outcome. Age-standardised seroprevalences were determined in sera from 1009 women childbearing age residing Mexico, Brazil, Germany, Poland, Turkey or China using a multiparametric immunoblot containing antigen substrates for Toxoplasma gondii , rubella virus, cytomegalovirus (CMV), herpes simplex viruses (HSV-1, HSV-2), Bordetella...
Objectives. Seasonal affective disorder (SAD) is a subtype of recurrent unipolar or bipolar depressive with higher prevalence in winter than summer. The biological underpinnings SAD are so far poorly understood. Studies examining have found disturbances between the molecular and connectivity scales. aim study was to explore changes functional typical for SAD. Methods. We investigated unmedicated, untreated patients healthy controls using resting-state magnetic resonance imaging (rs-fMRI)...
Abstract Introduction Functional magnetic resonance imaging ( fMRI ) combined with simultaneous electroencephalography EEG ‐ has become a major tool in mapping epilepsy sources. In the absence of detectable epileptiform activity, resting state may still detect changes blood oxygen level‐dependent signal, suggesting intrinsic alterations underlying brain physiology. Methods this study, we used coefficient variation CV critically sampled 10 Hz ultra‐fast (magnetoencephalography, MREG signal to...
Cross-frequency coupling between slow and fast brain rhythms, in the form of phase-amplitude (PAC), is proposed to enable coordination neural oscillatory activity required for cognitive processing. PAC has been identified neocortex mesial temporal regions, varying according task being performed also at rest. observed anterior thalamic nucleus (ATN) during memory The thalamus active resting state be involved switching task-free states such as rest, which attention internally-focused,...
Serological testing for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is used to detect ongoing or past SARS-CoV-2 infections. To study the kinetics of anti-SARS-CoV-2 and assess diagnostic performances eight serological assays, we 129 serum samples collected on known days post symptom onset (dpso) from 42 patients with polymerase chain reaction-confirmed disease 2019 (COVID-19) 54 healthy blood donors, children infected seasonal coronaviruses. The sera were...
Ultra-fast functional magnetic resonance encephalography (MREG) enables separate assessment of cardiovascular, respiratory, and vasomotor waves from brain pulsations without temporal aliasing. We examined effects breath hold- (BH) related changes on cardiovascular using MREG to study the physiological nature cerebrovascular reactivity. used alternating 32 s BH 88 resting normoventilation (NV) change during combined with simultaneously measured respiration, continuous non-invasive blood...
To understand the interplay between affective social information processing and its influence on mental states we investigated changes in functional connectivity (FC) patterns after audio exposure to emotional biographic narratives.While lying 7T MR scanner, 23 male participants listened narratives of early childhood experiences three persons, each having either a secure, dismissing, or preoccupied attachment representation. Directly prototypical narratives, underwent 10-minute resting-state...
Attachment patterns influence actions, thoughts and feeling through a person's "inner working model". Speech charged with attachment-dependent content was proposed to modulate the activation of cognitive-emotional schemata in listeners. We performed 7 Tesla rest-task-rest functional magnetic resonance imaging (fMRI)-experiment, presenting auditory narratives prototypical dismissing attachment representations investigate their effect on 23 healthy males. then examined effects participants'...