<h3>Context</h3> Major depressive disorder (MDD), panic disorder, and social anxiety are among the most prevalent frequently co-occurring psychiatric disorders in adults may have, at least part, a common etiology. <h3>Objective</h3> To identify unique shared neuroanatomical profile of depression anxiety, controlling for illness severity, medication use, sex, age onset, recurrence. <h3>Design</h3> Cross-sectional study. <h3>Setting</h3> Netherlands Study Depression Anxiety....

In the context of chronic childhood emotional maltreatment (CEM; abuse and/or neglect), adequately responding to facial expressions is an important skill. Over time, however, this adaptive response may lead a persistent vigilance for expressions. The amygdala and medial prefrontal cortex (mPFC) are key regions in face processing. However, neurobiological correlates processing adults reporting CEM yet unknown. We examined amydala mPFC reactivity faces (Angry, Fearful, Sad, Happy, Neutral) vs...

The neurobiology of social anxiety disorder (SAD) is not yet fully understood. Structural and functional neuroimaging studies in SAD have identified abnormalities various brain areas, particularly the amygdala elements salience network. This study first to examine resting-state connectivity a drug-naive sample patients without psychiatric comorbidity healthy controls, using seed regions interest bilateral amygdala, dorsal anterior cingulate cortex for network, posterior default mode Twelve...

Panic disorder (PD) is a prevalent and debilitating but its neurobiology still poorly understood. We investigated resting-state functional connectivity (RSFC) in PD without comorbidity three networks that have been linked to before. This could provide new insights how integration of brain regions involved fear panic might relate the symptomatology PD.Eleven patients eleven pair-wise matched healthy controls underwent fMRI. used seed regions-of-interest bilateral amygdala (limbic network),...

Background/Study Context: The ability to interpret emotionally salient stimuli is an important skill for successful social functioning at any age. objective of the present study was disentangle age and gender effects on emotion recognition in voices faces.Methods: Three groups participants (young, range: 18–35 years; middle-aged, 36–55 older, 56–75 years) identified basic emotions presented faces a forced-choice paradigm. Five (angry, fearful, sad, disgusted, happy) nonemotional category...

Background Depression has been associated with limbic hyperactivation and frontal hypoactivation in response to negative facial stimuli. Anxiety disorders have also increased activation of emotional structures such as the amygdala insula. This study examined what extent brain regions involved perception faces is specific depression anxiety a large community-based sample out-patients. Method An event-related functional magnetic resonance imaging (fMRI) paradigm was used including angry,...

Major depressive disorder (MDD) is characterized by affective symptoms and cognitive impairments, which have been associated with changes in limbic prefrontal activity as well monoaminergic neurotransmission. A genome-wide association study implicated the polymorphism rs2522833 piccolo (PCLO) gene—involved neurotransmission—as a risk factor for MDD. However, role of PCLO allele emotion processing executive function or its effect on their neural substrate has never studied. We used functional...

van Tol MJ, der Wee NJA, Demenescu LR, Nielen MMA, Aleman A, Renken R, Buchem MA, Zitman FG, Veltman DJ. Functional MRI correlates of visuospatial planning in out-patient depression and anxiety. Objective: Major depressive disorder (MDD) has been associated with executive dysfunction related abnormal prefrontal activity, whereas the status function (EF) frequently co-occurring anxiety disorders comorbid depression–anxiety is unclear. We aimed to study functional (visuospatial) MDD test for...

Avoidance to look others in the eye is a characteristic symptom of Autism Spectrum Disorders (ASD), and it has been hypothesised that quantitative monitoring gaze patterns could be useful objectively evaluate treatments. However, tools measure behaviour on regular basis at manageable cost are missing. In this paper, we investigated whether smartphone-based tool address problem. Specifically, assessed accuracy with which phone-based, state-of-the-art eye-tracking algorithm iTracker can...

Background Abnormal brain activations during processing of emotional facial expressions in depressed patients have been demonstrated. We investigated the natural course activation response to faces depression, indexed by functional magnetic resonance imaging (fMRI) scans preceding and following change depressive state. hypothesized a decrease amygdala, anterior cingulate cortex (ACC), insula with pathology. Methods A 2-year longitudinal fMRI study was conducted as part Netherlands Study...

Abstract A salience network (SN) anchored in the anterior insula (AI) and dorsal cingulate cortex (dACC) plays a key role switching between brain networks during detection attention regulation. Previous fMRI studies have associated expectancy behaviors SN activation with novelty seeking (NS) reward dependence (RD) personality traits. To address question of how functional connectivity (FC) is modulated by internal (expectancy‐related) assignment different traits, 68 healthy participants...

Emotion recognition deficits emerge with the increasing age, in particular, a decline identification of sadness. However, little is known about age-related changes emotion processing sensory, affective, and executive brain areas. This functional magnetic resonance imaging (fMRI) study investigated neural correlates auditory prosody across adult lifespan. Unattended detection emotional was assessed 21 young (age range: 18–35 years), 19 middle-aged 36–55 15 older 56–75 years) adults....

Through education, a social group transmits accumulated knowledge, skills, customs, and values to its members. So far, the best of our association between educational attainment neural correlates emotion processing has been left unexplored. In retrospective analysis The Netherlands Study Depression Anxiety (NESDA) functional magnetic resonance imaging (fMRI) study, we compared two groups fourteen healthy volunteers with intermediate high attainment, matched for age gender. data concerned...

To understand the interplay between affective social information processing and its influence on mental states we investigated changes in functional connectivity (FC) patterns after audio exposure to emotional biographic narratives.While lying 7T MR scanner, 23 male participants listened narratives of early childhood experiences three persons, each having either a secure, dismissing, or preoccupied attachment representation. Directly prototypical narratives, underwent 10-minute resting-state...

Attachment patterns influence actions, thoughts and feeling through a person's "inner working model". Speech charged with attachment-dependent content was proposed to modulate the activation of cognitive-emotional schemata in listeners. We performed 7 Tesla rest-task-rest functional magnetic resonance imaging (fMRI)-experiment, presenting auditory narratives prototypical dismissing attachment representations investigate their effect on 23 healthy males. then examined effects participants'...

The brain's connectivity skeleton – a rich club of strongly interconnected members - was initially shown to exist in human structural networks, but recent evidence suggests functional counterpart. This typically includes key regions (or hubs) from multiple canonical reducing the cost inter-network communication. posterior cingulate cortex (PCC), hub node embedded within default mode network, is known facilitate communication between brain networks and member 'rich club'. Here, we assessed...

Anxiety disorders are common and debilitating conditions with higher prevalence in women. However, factors that predispose women to anxiety phenotypes not clarified. Here we investigated potential contribution of the single nucleotide polymorphism rs2236418 GAD2 gene changes regional inhibition/excitation balance, anxiety-like traits, related neural activity both sexes. One hundred five healthy individuals were examined high-field (7T) multimodal magnetic resonance imaging (MRI); including...