A5010691356- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Photoacoustic and Ultrasonic Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced MRI Techniques and Applications
- Wireless Body Area Networks
- Microwave Imaging and Scattering Analysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Cerebrospinal fluid and hydrocephalus
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Infrared Thermography in Medicine
- Ultrasound and Hyperthermia Applications
- Antenna Design and Analysis
- Spectroscopy and Chemometric Analyses
- Atomic and Subatomic Physics Research
- Advanced Chemical Sensor Technologies
- Wireless Communication Networks Research
- Ultra-Wideband Communications Technology
- Brain Tumor Detection and Classification
- Indoor and Outdoor Localization Technologies
- Thermoregulation and physiological responses
University of Oulu
2016-2025
Oulu University Hospital
1983-2024
Indian Institute of Technology BHU
2023
Banaras Hindu University
2023
Politecnico di Milano
2023
Technische Universität Dresden
2023
Thapar Institute of Engineering & Technology
2023
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion hyperosmolar mannitol improves outcome in primary central nervous system lymphoma. Proper is crucial for treatment, yet there are no means available its real-time monitoring. The intact maintains a mV-level electrical potential difference between blood and brain tissue, giving rise to measurable signal at scalp. Therefore, we used direct-current electroencephalography (DC-EEG) characterize spatiotemporal...
The development of new medical monitoring applications requires precise modeling the human body effects as well simulating and emulating realistic scenarios conditions. first aim this paper is to develop adjustable 3D emulation platforms which could be used for evaluating emerging microwave-based monitoring/sensing such detection brain tumors, strokes, breast cancers capsule endoscopy studies. phantom recipes are developed microwave ranges shaped molds. second validate feasibility...
In study of the brain, oxygenation changes in cerebral cortex are great interest, since concentrations oxyhaemoglobin and deoxyhaemoglobin change due to coupling hemodynamics cortical neural activity. order non-invasively monitor by near-infrared spectroscopy (NIRS), light should penetrate into brain tissue a depth approximately 1-2 cm. Many studies show that increasing source-detector distance, illuminating penetrates deeper tissue. Using tissue-mimicking phantom measurements, forehead vivo...
Functional connectivity of the resting-state networks brain is thought to be mediated by very-low-frequency fluctuations (VLFFs <0.1 Hz) in neuronal activity. However, vasomotor waves and cardiorespiratory pulsations influence indirect measures function, such as functional magnetic resonance imaging blood-oxygen-level-dependent (BOLD) signal. How strongly physiological oscillations correlate with spontaneous BOLD signals not known, partially due differences data-sampling rates different...
Fluctuations in brain water content has attracted increasing interest, particularly as regards studies of the glymphatic system, which is connected with complex organization dural lymphatic vessels, responsible for cleaning tissue. Disturbances circulation are associated several disorders, including dementia. This article introduces an approach to noninvasive measurement dynamics human utilizing near-infrared spectroscopy (NIRS). We demonstrate possibility sense dynamic variations between...
Inside the incompressible cranium, volume of cerebrospinal fluid is directly linked to blood volume: a change in either will induce compensatory other. Vasodilatory lowering pressure has been shown result an increase intracranial pressure, which, normal circumstances should return equilibrium by increased efflux. In this study, we investigated effect on fluorescent tracer absorption into systemic circulation. Blood was performed i.v. administration nitric oxide donor (sodium nitroprusside, 5...
The development of new medical-monitoring applications requires precise modeling effects on the human body as well simulation and emulation realistic scenarios conditions. first aim this paper is to develop adjustable 3D human-body platforms that could be used for evaluating emerging microwave-based medical monitoring/sensing such detection brain tumors, strokes, breast cancers, capsule endoscopy studies. New phantom recipes are developed microwave ranges molds with shapes. second validate...
Epilepsy causes measurable irregularity over a range of brain signal frequencies, as well autonomic nervous system functions that modulate heart and respiratory rate variability. Imaging dynamic neuronal signals utilizing simultaneously acquired ultra-fast 10 Hz magnetic resonance encephalography (MREG), direct current electroencephalography (DC-EEG), near-infrared spectroscopy (NIRS) can provide more comprehensive picture human function. Spectral entropy (SE) is nonlinear method to...
This report focuses on designing and implementing a non-invasive blood pressure (NIBP) measuring device capable of being used during magnetic resonance imaging (MRI). Based pulse wave velocity in arterial blood, the uses obtained result to estimate diastolic pressure. Pulse transit times are measured by two fibre optical accelerometers placed over chest carotid artery. The fabricated accelerometer contains static fibres cantilever beam, whose free end is angled at 90 degrees act as...
Abstract A comparative application of major dynamic light scattering (DLS)‐based image methodologies applied to transcranial cerebral blood flow imaging is presented. In particular, the study delves into assessing capability Laser Doppler Flowmetry (LDF), Speckle Contrast Imaging (LSCI), and Diffuse Correlation Spectroscopy (DCS) in enhancing spatial temporal resolution imaging. An integral part focused on modulation through administration vasodilator drug, Sodium Nitroprusside (SNP). This...
The possibility to detect severity of skull fractures outside the hospital already in accident location would be a promising eHealth application. Such point-of-care type device smoothen patients’ path treatment after accident. Additionally, frequent and safe monitoring healing process smaller healthcare centers, as new telemedicine solution, enable early detection potential problems. Microwave technique has shown significant for portable devices since it enables safe, low-cost, high accuracy...
Interests towards wireless portable medical diagnostics and monitoring systems, which could be used outside hospital e.g. during pandemic or catastrophic situations, have increased recently. Additionally, solutions partially address widely recognized challenges related to healthcare equality in rural areas. Microwave based sensing has recently been as emerging technology for devices since they may enable development of safe, reliable, low-cost future’s telemedicine. The aim this paper is...
Abstract In-vivo microscopical studies indicate that brain cerebrospinal fluid (CSF) transport driven by blood vessel pulsations is reduced in the early stages of Alzheimer’s disease (AD). We hypothesized coupling pattern between cerebrovascular and CSF altered AD, this can be measured using multi-wavelength functional near-infrared spectroscopy (fNIRS). To study this, we quantified simultaneously cerebral hemo- hydrodynamics AD patients age-matched healthy controls. Physiological were...
A non-invasive device for measuring blood oxygen variations in human brain is designed, implemented, and tested MRI compatibility. The based on principles of near-IR reflectometry; power LEDs serve as sources probing radiation delivered to patient skin surface through optical fibres. Numerical Monte Carlo simulations propagation a multilayer model are performed evaluate signal levels at different source — detector separations three operation wavelengths an additional wavelength 915 nm. It...
Ultra-fast functional magnetic resonance encephalography (MREG) enables separate assessment of cardiovascular, respiratory, and vasomotor waves from brain pulsations without temporal aliasing. We examined effects breath hold- (BH) related changes on cardiovascular using MREG to study the physiological nature cerebrovascular reactivity. used alternating 32 s BH 88 resting normoventilation (NV) change during combined with simultaneously measured respiration, continuous non-invasive blood...
SignificanceCancer therapy treatments produce extensive changes in the physiological and morphological properties of tissues, which are also individual dependent. Currently, a key challenge involves developing more tailored cancer therapy, consequently, biological response measurement during such as tumor hypoxia, is high interest. This first time human cerebral haemodynamics tissue oxygenation index (TOI) were measured irradiation clinical radiotherapy functional near-infrared spectroscopy...
Functional near-infrared spectroscopy (fNIRS) has been utilized already around three decades for monitoring the brain, in particular, oxygenation changes cerebral cortex. In addition, other optical techniques are currently developed vivo imaging and near future can be potentially used more human brain research. This paper reviews most common label-free technologies exploited their current potential clinical applications. Label-free tissue do not require addition of dyes or molecular contrast...
This paper presents experimental measurements conducted using two noninvasive fibre optic methods for detecting heart pulse waves in the human body. Both can be used conjunction with magnetic resonance imaging (MRI). For comparison, also performs an MRI-compatible electrocardiogram (ECG) measurement. By simultaneous use of different measurement methods, propagation pressure generated by each sensed extensively areas body and at depths, example, on chest forehead fingertip. An accurate...
In study of the brain, oxygenation changes in cerebral cortex are increasingly monitored using optical methods based on near-infrared spectroscopy (NIRS). When monitoring blood cortex, at depth approximately 15 mm - 20 from skin surface, separation distance between source and detector becomes significant. Many studies show that by increasing source-detector distance, illuminating light penetrates deeper into tissue. this work, we use phantoms to determine experimentally minimum allows...