A5103046654- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Cellular Mechanics and Interactions
- Cardiovascular Effects of Exercise
- Cerebrospinal fluid and hydrocephalus
- Machine Learning in Bioinformatics
- Electrospun Nanofibers in Biomedical Applications
- Genetic Associations and Epidemiology
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Rare Diseases
- Bioinformatics and Genomic Networks
- Traumatic Brain Injury and Neurovascular Disturbances
- Force Microscopy Techniques and Applications
- Medicinal Plant Pharmacodynamics Research
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Biomedical and Engineering Education
- Cardiac Structural Anomalies and Repair
- Intracerebral and Subarachnoid Hemorrhage Research
- Web Data Mining and Analysis
- Apelin-related biomedical research
- Gene Regulatory Network Analysis
- Text and Document Classification Technologies
- DNA and Nucleic Acid Chemistry
- thermodynamics and calorimetric analyses
University of Oulu
2022-2025
Vellore Institute of Technology University
2016-2023
Vardhman Mahavir Medical College & Safdarjung Hospital
2022
University of California, San Francisco
2014
Rutgers, The State University of New Jersey
2007-2014
Johnson University
2007-2009
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic vessel development, mutations of ANGPT2 were recently found However, mechanistic basis Ang2 activity not fully understood. Here, we used deletion, blocking Abs, transgene induction, transfer to study how Ang2, its Tie2 receptor, Tie1 vessels. We...
Abstract Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest their possible involvement Alzheimer’s disease (AD). Here we find APdE9 and 5xFAD mouse models AD, amyloid-β (Aβ) is confined to blood dLV morphology or function not altered. The induction sustained atrophy hyperplasia AD mice by blocking overexpressing C, impaired improved, respectively, macromolecular...
Inside the incompressible cranium, volume of cerebrospinal fluid is directly linked to blood volume: a change in either will induce compensatory other. Vasodilatory lowering pressure has been shown result an increase intracranial pressure, which, normal circumstances should return equilibrium by increased efflux. In this study, we investigated effect on fluorescent tracer absorption into systemic circulation. Blood was performed i.v. administration nitric oxide donor (sodium nitroprusside, 5...
Abstract Background The perivascular conduct pathway that connects the cerebrospinal fluid spaces with interstitial in parenchyma are of importance for solute clearance from brain. In this pathway, relatively wide space (PVS) surrounding pial arteries provides a low-resistant passage while around perforating arteries, movement is along basement membrane (BM), prevents free exchange fluids and solutes. We hypothesize selectivity involves specific components vascular BM, which mainly composed...
Background Tropomyosin is a prototypical coiled coil along its length with subtle variations in structure that allow interactions actin and other proteins. Actin binding globally stabilizes tropomyosin. Tropomyosin-actin interaction occurs periodically the of However, it not well understood how tropomyosin binds actin. Principal Findings Tropomyosin's periodic sites make differential contributions to two components binding, cooperativity affinity, can be classified as primary or secondary...
Tropomyosin is a coiled coil that associates N-terminus to C-terminus form continuous strand along both sides of the actin filament and regulates its function. One long, high molecular weight tropomyosin molecule spans length seven subunits. In these forms there 7-fold periodicity in noninterface residues have been proposed correspond quasi-equivalent binding sites. Interruption stable, canonical by destabilize interhelical interface, such as Ala clusters, required for binding. Previous...
The potential alterations to structure and associations with thin filament proteins caused by the dilated cardiomyopathy (DCM) associated tropomyosin (Tm) mutants E40K E54K, hypertrophic (HCM) Tm E62Q L185R, were investigated. In order ascertain what cause of known functional effects may be, structural protein-protein interaction studies conducted utilizing actomyosin ATPase activity measurements spectroscopy. measurements, both HCM DCM mutant E54K increases in Ca2+-induced maximal...
Abstract Background Inside the incompressible cranium, volume of cerebrospinal fluid (CSF) is directly linked to blood volume: a change in either will induce compensatory other. Vasodilatory lowering pressure has been shown result an increase intracranial pressure, which, normal circumstances should return equilibrium by increased efflux. In this study, we investigated effect (BPL) on fluorescent CSF tracer absorption into systemic circulation. Methods BPL was performed i.v. administration...
Mesenchymal stem cells, because of their ability to differentiate along variable cell lineages and renew themselves is a topic interest in orthopedics for potential role avascular necrosis femoral head, osteoarthritis, intervertebral disc disease, ligamentous meniscal injuries, inducing growth osteogenesis imperfecta gene therapy. They also possess immunosuppressive immunomodulatory properties. cells can be procured from different tissue sources, such as umbilical cord, synovial tissue,...