A5083343203- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Healthcare Systems and Technology
- Telemedicine and Telehealth Implementation
- Cerebrospinal fluid and hydrocephalus
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Electronic Health Records Systems
- Mobile Health and mHealth Applications
- Innovations in Medical Education
- EEG and Brain-Computer Interfaces
- Hormonal and reproductive studies
- Migraine and Headache Studies
- Neuroscience and Neuropharmacology Research
- Diversity and Career in Medicine
- Microtubule and mitosis dynamics
- MRI in cancer diagnosis
- Trigeminal Neuralgia and Treatments
- Alzheimer's disease research and treatments
- Social Media in Health Education
- Health Literacy and Information Accessibility
- Medical Education and Admissions
- Sleep and Wakefulness Research
Oulu University Hospital
2015-2025
University of Oulu
2015-2025
University of Turku
1964-2009
Kuopio University Hospital
2002
Tampere University
1977-1994
Tampere University Hospital
1994
The theory on the glymphatic convection mechanism of cerebrospinal fluid holds that cardiac pulsations in part pump from peri-arterial spaces through extracellular tissue into peri-venous facilitated by aquaporin water channels. Since pulses cannot be sole propulsion, we searched for additional human brain with ultra-fast magnetic resonance encephalography. We detected three types physiological mechanisms affecting cerebral pulsations: cardiac, respiratory, and very low frequency pulsations....
The physiological underpinnings of the necessity sleep remain uncertain. Recent evidence suggests that increases convection cerebrospinal fluid (CSF) and promotes export interstitial solutes, thus providing a framework to explain why all vertebrate species require sleep. Cardiovascular, respiratory vasomotor brain pulsations have each been shown drive CSF flow along perivascular spaces, yet it is unknown how such may change during in humans. To investigate these pulsation phenomena relation...
Accumulation of amyloid-β is a key neuropathological feature in brain Alzheimer's disease patients. Alterations cerebral haemodynamics, such as arterial impulse propagation driving the (peri)vascular CSF flux, predict future progression. We now present non-invasive method to quantify three-dimensional cardiovascular impulses human using ultrafast 10 Hz magnetic resonance encephalography. This technique revealed spatio-temporal abnormalities disease. The arrival latency and speed both...
Low image sampling rates used in resting state functional magnetic resonance imaging (rs-fMRI) may cause aliasing of the cardiorespiratory pulsations over very low frequency (VLF) BOLD signal fluctuations which reflects to connectivity (FC). In this study, we examine effect rate on currently rs-fMRI FC metrics. Ultra-fast fMRI encephalography (MREG) data, sampled with TR 0.1 s, was downsampled different subsampled repetition times (sTR, range 0.3-3 s) for comparisons. Echo planar k-space (TR...
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion hyperosmolar mannitol improves outcome in primary central nervous system lymphoma. Proper is crucial for treatment, yet there are no means available its real-time monitoring. The intact maintains a mV-level electrical potential difference between blood and brain tissue, giving rise to measurable signal at scalp. Therefore, we used direct-current electroencephalography (DC-EEG) characterize spatiotemporal...
Abstract Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer’s disease (AD) symptoms could improve detection and enable timely interventions. Changes brain hemodynamics may be associated with the main clinical AD symptoms. To test this possibility, we measured variability of blood oxygen level-dependent (BOLD) signal individuals from three independent datasets (totaling 80 patients 90 controls). We detected a replicable increase BOLD populations, which...
Sleep increases brain fluid transport and the power of pulsations driving fluids. We investigated how sleep deprivation or electrophysiologically different stages non-rapid-eye-movement (NREM) affect human pulsations.Fast functional magnetic resonance imaging (fMRI) was performed in healthy subjects (n = 23) with synchronous electroencephalography (EEG), that used to verify arousal states (awake, N1 N2 sleep). Cardiorespiratory rates were verified physiological monitoring. Spectral analysis...
eHealth increasingly affects the delivery of health care around world and quest for more efficient systems. In Finland, development maturity has been systematically studied since 2003, through surveys conducted every 3 years. It also monitored in several international studies. The indicators used these studies examined availability electronic patient record, picture archiving communication system, information exchange, other key functionalities.The first aim is to study national level...
Digitalisation is rapidly changing health care processes and the sector, thus increasing need to improve digital competence of future professionals.The aim this study was describe attitudes medical nursing students towards based on self-evaluation as well compare differences in perceptions between two student groups.A cross-sectional conducted an online survey using Webropol April 2021 at University Oulu Applied Sciences Finland. The questionnaire consisted seven background questions 16...
Epilepsy causes measurable irregularity over a range of brain signal frequencies, as well autonomic nervous system functions that modulate heart and respiratory rate variability. Imaging dynamic neuronal signals utilizing simultaneously acquired ultra-fast 10 Hz magnetic resonance encephalography (MREG), direct current electroencephalography (DC-EEG), near-infrared spectroscopy (NIRS) can provide more comprehensive picture human function. Spectral entropy (SE) is nonlinear method to...
The brain is cleaned from waste by glymphatic clearance serving a similar purpose as the lymphatic system in rest of body. Impairment precedes protein accumulation and reduced cognitive function Alzheimer's disease (AD). Cardiovascular pulsations are primary driving force clearance. We developed method to quantify cardiovascular pulse propagation human with magnetic resonance encephalography (MREG). extended standard optical flow estimation three spatial dimensions, multi-resolution...
Purpose This study aims to investigate final-year medical students’ perceptions regarding the significance of different managerial roles in fulfilling physician leaders’ work. Design/methodology/approach In 2020, an electronic questionnaire was distributed all students at University Oulu, Finland. A quantitative analysis roles, based on Mintzberg’s model, utilized statements rated a five-point Likert scale. Statistical assessments examined differences role importance relative age, gender,...
Electronic Health Record (EHR) systems continually evolve to meet the demands of user organizations, national authorities, and end users. Finland, a digital health pioneer, encountered challenges like system fragmentation interoperability despite early EHR adoption. The rollout information exchange (Kanta) services sought address these issues but also introduced new usability concerns. In cross-sectional surveys conducted among physicians in 2010, 2014, 2017, 2021, we asked respondents...
Purpose A unique aspect of the Finnish healthcare system is that medical students can assume formal doctoral positions under specific circumstances while still pursuing their studies. This study investigates prevalence such engagements and examines whether factors as gender, age, or pre-medical school educational background influence work experience. Design/methodology/approach An electronic survey was distributed to final-year in 2020. The explored experience roles, including duration...
Resting-state fMRI results in neurodegenerative diseases have been somewhat conflicting. This may be due to complex partial volume effects of CSF BOLD signal patients with brain atrophy. To encounter this problem, we used a coefficient variation (CV) map highlight artifacts the data, followed by analysis gray matter voxels order minimize between groups. The these measures were compared whole ICA dual regression Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD)....
Abstract Introduction Functional magnetic resonance imaging ( fMRI ) combined with simultaneous electroencephalography EEG ‐ has become a major tool in mapping epilepsy sources. In the absence of detectable epileptiform activity, resting state may still detect changes blood oxygen level‐dependent signal, suggesting intrinsic alterations underlying brain physiology. Methods this study, we used coefficient variation CV critically sampled 10 Hz ultra‐fast (magnetoencephalography, MREG signal to...
Respiratory brain pulsations have recently been shown to drive electrophysiological activity in patients with epilepsy. Furthermore, functional neuroimaging indicates that respiratory increased variability and amplitude epilepsy compared healthy individuals. To determine whether the is altered epilepsy, we pulsation synchronicity between controls patients. Whole fast magnetic resonance imaging was performed on 40 medicated focal 20 drug-naïve 102 controls. Cerebrospinal fluid associated were...
Abstract Resting-state functional MRI has shown potential for detecting changes in cerebral blood oxygen level-dependent signal patients with epilepsy, even the absence of epileptiform activity. Furthermore, it been suggested that coefficient variation mapping fast may provide a powerful tool identification intrinsic brain pulsations neurological diseases such as dementia, stroke and epilepsy. In this study, we used sequence (magnetic resonance encephalography) to acquire ten whole-brain...
Electronic health care (e-health) services intended for Finnish citizens have been recently developed nationally, regionally, and locally through several projects programs. This study aimed to investigate the development availability of e-health in specialized primary private medical service providers from 2011 2020. In addition, differences between different sectors regional hospital districts were investigated. Data collected using web-based questionnaires 2011, 2014, 2017, 2020 “Use...
SYNOPSIS Clonidine chloride, 25 ug three times per day, decreased the mean number of headache attacks month to 2.26 compared 3.94 before treatment and 2.98 during placebo use in 50 migraineurs. Fifty clonidine t.i.d. from 4 1.88 2.49 placebo. Frequency 44% patients, were unchanged 46% patients increased 10% on t.i.d., 58% frequency was 40% 1%. Practolol, a beta adrenergic blocker, 41% attack 42% 16% receiving it mg Mean duration 3.86 hours 2.16 after dosage 1.86 clondine dose. Attack 2.37...
The physiological pulsations that drive tissue fluid homeostasis are not well characterized during brain activation. Therefore, we used fast magnetic resonance encephalography (MREG) fMRI to measure full band (0–5 Hz) blood oxygen level-dependent (BOLD FB ) signals a dynamic visual task in 23 subjects. This revealed activity the very low frequency VLF as cardiac and respiratory bands. cardiovascular hemodynamic envelope (CHe) signal correlated significantly with BOLD response, considered an...
Primary central nervous system lymphoma (PCNSL) is an aggressive brain disease where lymphocytes invade along perivascular spaces of arteries and veins. The invasion markedly changes (peri)vascular structures but its effect on physiological pulsations has not been previously studied. Using magnetic resonance encephalography (MREGBOLD ) scanning, this study aims to quantify the extent which PCNSL involvement alters stability mediated by cerebral vasculature. Clinical implications relevance...