Eva Mennigen
A5065772667- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Mental Health Research Topics
- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Eating Disorders and Behaviors
- Advanced MRI Techniques and Applications
- Substance Abuse Treatment and Outcomes
- Stress Responses and Cortisol
- Coronary Artery Anomalies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
- Prenatal Substance Exposure Effects
- Memory and Neural Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Congenital Heart Disease Studies
- Traumatic Brain Injury Research
- EEG and Brain-Computer Interfaces
- Genetic Associations and Epidemiology
- Cognitive Abilities and Testing
TU Dresden
2012-2024
University of Tübingen
2024
University Hospital Carl Gustav Carus
2016-2021
University of California, Los Angeles
2018-2021
Neurobehavioral Systems
2019
Cognitive Neuroimaging Lab
2016-2019
Inserm
2019
Université Paris Cité
2019
Neuroimaging and Psychiatry
2019
University of New Mexico
2016-2018
During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, molecular mechanisms supporting connectivity remain undefined. We show that networks defined with resting-state magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem tissue data set. The set 136 genes we identify significantly enriched for ion channels. Polymorphisms this affect large...
Novelty-seeking tendencies in adolescents may promote innovation as well problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability these individuals. Here we use a longitudinal design track 144 novelty-seeking at age 14 and 16 determine activity response predicts use. We find that diminished BOLD mesolimbic (ventral striatal midbrain) prefrontal cortical (dorsolateral...
Significance We characterize in humans a coordinated network of brain activity describing neurobehavioral correlates reward anticipation. The involves nodes striatal and cortical regions, which are preferentially associated with distinct externalizing behaviors—hyperactivity alcohol consumption—suggesting that the heterogeneity reward-related behaviors might be accounted for by different association patterns their connecting links. In genome-wide study node subsequent functional validation...
This study examines the effects of puberty and sex on intrinsic functional connectivity (iFC) brain networks, with a focus default-mode network (DMN). Consistently implicated in depressive disorders, DMN's function may interact development these whose onsets peak adolescence, which show strong disproportionality (females > males). The main question concerns how DMN evolves as sex. These are expected to involve within- between-network iFC, particularly, salience central-executive consistent...
Alcohol abuse is highly prevalent, but little understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We required adult nervous system for normal it acts downstream of integrin cell adhesion molecule upstream Ras-related C3 botulinum toxin substrate (Rac1) GTPase regulate actin cytoskeleton. In an preference assay, global loss causes high...
Higher rates of substance use and dependence have been observed in the offspring mothers who smoked during pregnancy. Animal studies indicate that prenatal exposure to nicotine alters development brain areas related reward processing, which might be a risk factor for addiction later life. However, no study has examined effect maternal smoking on offspring's response processing.To determine whether adolescents with cigarette differ from their nonexposed peers ventral striatum anticipation or...
This study investigated the prevalence of disordered eating cognitions and behaviours across mid-adolescence in a large European sample, explored extent to which ratings were affected by informant (parent/adolescent), or sex age adolescent. The Development Well-Being Assessment was completed parent–adolescent dyads at 14 (n = 2225) again 16 1607) explore 7 disorder symptoms (binge eating, purging, fear weight gain, distress over shape/weight, avoidance fattening foods, food restriction,...
Psychotic disorders are characterized by attenuated activity in the brain's valuation system key reward processing areas, such as ventral striatum (VS), measured with functional magnetic resonance imaging.To examine whether common risk variants for psychosis associated individual variation VS.A cross-sectional study of a large cohort adolescents from IMAGEN (a European multicenter reinforcement sensitivity adolescents) was performed March 1, 2008, through December 31, 2011. Data analysis...
Huntington's disease (HD) is an inherited brain disorder characterized by progressive motor, cognitive, and behavioral dysfunctions. It caused abnormally large trinucleotide cytosine-adenine-guanine (CAG) repeat expansions on exon 1 of the Huntingtin gene. CAG length (CAG-RL) inversely correlates with earlier age onset. Region-based studies have shown that HD gene mutation carrier (HDgmc) individuals (CAG-RL ≥36) present functional connectivity alterations in subcortical (SC) default mode...
Longitudinal developmental fMRI studies just recently began to focus on within-subject reliability using the intraclass coefficient (ICC). It remains largely unclear which degree of can be achieved in and whether this depends type task used. Therefore, we aimed systematically investigate three well-classified tasks: an emotional attention, a cognitive control, intertemporal choice paradigm. We hypothesized find higher than or reward-related task. 104 healthy mid-adolescents were scanned at...
While a number of studies have established that moderate doses alcohol increase brain perfusion, the time course such an as function breath concentration (BrAC) has not yet been investigated, and differ about regional effects. Using arterial spin labeling (ASL) magnetic resonance imaging, we investigated (1) perfusion during 15-minute linear BrAC up to 0.6 g/kg followed by steady exposure 100 minutes, (2) distribution, (3) potential gender effect, (4) temporal stability In 48 young adults...
Schizophrenia shows abnormal dynamic functional network connectivity (dFNC), but it is unclear whether these abnormalities are present early in the illness course or precede onset individuals at clinical high risk (CHR) for psychosis. We examined dFNC from resting-state magnetic resonance imaging data CHR (n = 53), schizophrenia (ESZ; n 58), and healthy control (HC; 70) individuals. applied a sliding temporal window approach capturing five distinct states. In ESZ patients, likelihood of...