A5066686513- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Physics of Superconductivity and Magnetism
- Advanced Condensed Matter Physics
- Magnetism in coordination complexes
- Genetics and Neurodevelopmental Disorders
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Mental Health Research Topics
- Theoretical and Computational Physics
- Advanced MRI Techniques and Applications
- Bioinformatics and Genomic Networks
- Magnetic properties of thin films
- Schizophrenia research and treatment
- Magnetic and transport properties of perovskites and related materials
- Mesoporous Materials and Catalysis
- Muon and positron interactions and applications
Cardiff University
2016-2025
University of Bath
2020-2025
UK Dementia Research Institute
2019-2025
Akston Biosciences (United States)
2024
Medical Research Council
2016-2021
University of Amsterdam
2020
Genomics (United Kingdom)
2016-2019
Mental Health Research Institute
2019
Jackson Memorial Hospital
2018
University of Mississippi Medical Center
2018
We studied resting-state oscillatory connectivity using magnetoencephalography in healthy young humans (N = 183) genotyped for APOE-ɛ4, the greatest genetic risk Alzheimer’s disease (AD). Connectivity across frequencies, but most prevalent alpha/beta, was increased APOE-ɛ4 a set of mostly right-hemisphere connections, including lateral parietal and precuneus regions Default Mode Network. Similar also demonstrated hyperactivity, only gamma (40–160 Hz). In separate study AD patients,...
BackgroundRecent genome-wide association studies have identified genetic loci that jointly make a considerable contribution to risk of developing Alzheimer's disease (AD). Because neuropathological features AD can be present several decades before onset, we investigated whether effects polygenic are detectable by neuroimaging in young adults. We hypothesized higher scores (PRSs) for would associated with reduced volume the hippocampus and other limbic paralimbic areas. further PRSs affect...
Abstract Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, diagnostic predictive power of existing algorithms has been limited by small sample sizes, lack representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with largest multi-site size date (N = 5365) provide a generalizable ML classification benchmark major depressive disorder (MDD) using shallow...
We present evidence of magnetic order in the quasi-one-dimensional spin-1/2 molecular chain compound, copper pyrazine dinitrate $\mathrm{Cu}({\mathrm{C}}_{4}{\mathrm{H}}_{4}{\mathrm{N}}_{2}){(\mathrm{N}{\mathrm{O}}_{3})}_{2}$. Zero field muon-spin relaxation measurements made at dilution refrigerator temperatures show oscillations measured asymmetry characteristic a quasistatic muon sites. Our provide convincing for long-range below temperature...
The aim of this study is to determine the effects oil solutes and alcohol cosolvents on structure oil-in-water microemulsions stabilized by poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide) (PEO−PPO−PEO) triblock copolymers. systems investigated involved solubilization 1,3,5-trimethylbenzene or 1,2-dichlorobenzene P123 (EO20−PO70−EO20) pluronic surfactant micelles in water + ethanol solvents. structures these swollen were determined small-angle neutron scattering (SANS). A...
Psychotic disorders are characterized by attenuated activity in the brain's valuation system key reward processing areas, such as ventral striatum (VS), measured with functional magnetic resonance imaging.To examine whether common risk variants for psychosis associated individual variation VS.A cross-sectional study of a large cohort adolescents from IMAGEN (a European multicenter reinforcement sensitivity adolescents) was performed March 1, 2008, through December 31, 2011. Data analysis...
The Na-K-2Cl cotransporter 2 (NKCC2) was thought to be kidney specific. Here we show expression in the brain hypothalamo-neurohypophyseal system (HNS), wherein upregulation follows osmotic stress. HNS controls stability through synthesis and release of neuropeptide hormone, arginine vasopressin (AVP). AVP travels bloodstream kidney, where it promotes water conservation. Knockdown NKCC2 elicited profound effects on fluid balance following ingestion a high-salt solution—rats produced...
The organic radical-ion salt DEOCC-TCNQF4 contains linear chains of stacked molecules with significant Heisenberg antiferromagnet interactions along the chain and extremely weak between chains. Zero-field muSR has confirmed absence long-range magnetic order down to 20 mK field-dependent is found be consistent diffusive motion spin excitations. anisotropic dynamics upper boundary for ordering temperature both indicate interchain coupling /J'/<7 mK. As intrachain J 110 K, /J'/J/ significantly...
A functional variant of the catechol-O-methyltransferase (COMT) gene [val158met (rs4680)] is frequently implicated in decision-making and higher cognitive functions. It may achieve its effects by modulating dopamine-related reward-guided behaviour. Here we demonstrate that individuals with met/met polymorphism have greater responsiveness to reward than carriers val allele this correlates risk-seeking We assessed performance on a task Balloon analogue risk task, which measure how participants...
Risk profile scores (RPS) derived from genome-wide association studies (GWAS) explain a considerable amount of susceptibility for schizophrenia (SCZ). However, little is known about how common genetic risk factors SCZ influence the structure and function human brain, largely due to constraints imaging sample sizes. In current study, we use novel recall-by-genotype (RbG) methodological approach, where young adults population cohort (Avon Longitudinal Study Parents Children: N genotyped =...
Abstract Introduction Genome‐wide association studies identify rs11136000 in the CLU gene, which codes for Apolipoprotein J/Clusterin, as a significant risk variant Alzheimer's disease (AD). However, mechanisms by this confers susceptibility remain relatively unknown. Methods Eighty‐five healthy Caucasian participants underwent functional magnetic resonance imaging during working memory (WM) task and were genotyped rs11136000/ APOE loci. Results Here we show that young individuals with (C)...
The cerebral cortex underlies our complex cognitive capabilities, yet we know little about the specific genetic loci influencing human cortical structure. To identify variants, including structural impacting structure, conducted a genome-wide association meta-analysis of brain MRI data from 51,662 individuals. We analysed surface area and average thickness whole 34 regions with known functional specialisations. identified 255 nominally significant ( P ≤ 5 × 10 −8 ); 199 survived multiple...
Abstract This paper introduces the Welsh Advanced Neuroimaging Database (WAND), a multi-scale, multi-modal imaging dataset comprising in vivo brain data from 170 healthy volunteers (aged 18–63 years), including 3 Tesla (3 T) magnetic resonance (MRI) with ultra-strong (300 mT/m) field gradients, structural and functional MRI nuclear spectroscopy at T 7 T, magnetoencephalography (MEG), transcranial stimulation (TMS), together trait questionnaire cognitive data. Data are organised using Brain...
An editorial in the BMJ recommended discontinuation of routine use chloramphenicol eye drops largely on basis case reports suggesting an association between their and serious haematological toxicity, particularly aplastic anaemia. 1 Although this recommendation has been challenged, debate not informed by reliable estimates size any risk. 2 Around 400 general practices United Kingdom contribute anonymised data to practice research database.They record prescriptions diagnoses from...
Abstract A substantial proportion of schizophrenia liability can be explained by additive genetic factors. Risk profile scores (RPS) directly index risk using a summated total common variants weighted their effect. Previous studies suggest that RPS predict alterations to neural networks support working memory and verbal fluency. In this study, we apply fMRI data elucidate the effects polygenic on functional brain during probabilistic‐learning neuroimaging paradigm. The recruited paradigm...
Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Cav1.2 L-type voltage-gated calcium channels (VGCCs), has been strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. How genetic CACNA1C contributes these is however not fully known. Both disorder are associated with impairments reversal learning (RL), may contribute symptoms seen conditions. We used a translational RL paradigm investigate whether affects both humans transgenic rats....
Abstract Pre‐clinical and human neuroimaging research implicates the extended‐amygdala (ExtA) (including bed nucleus of stria terminalis [BST] central amygdala [CeA]) in networks mediating negative emotional states associated with stress substance‐use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised large sample ( n > 1,000 healthy young adult humans) compare intrinsic functional connectivity (ICNs) BST CeA using...
The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. We investigated whether this risk affects reward responsiveness because processing one of central cognitive-motivational domains implicated disorders. In a sample 164 young, healthy individuals, we show dose-dependent response, where genotype was blunted responsiveness, whereas discriminability did not significantly differ...