A5081288265- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Balance, Gait, and Falls Prevention
- Motor Control and Adaptation
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Behavioral and Psychological Studies
- Family and Disability Support Research
- Children's Physical and Motor Development
- Genetics and Neurodevelopmental Disorders
- Veterinary Pharmacology and Anesthesia
- Child Development and Digital Technology
- Pharmacological Effects and Assays
- Veterinary Equine Medical Research
- Language Development and Disorders
- Child Nutrition and Feeding Issues
- Assistive Technology in Communication and Mobility
- Vestibular and auditory disorders
- Microtubule and mitosis dynamics
- Stroke Rehabilitation and Recovery
- Genetic Neurodegenerative Diseases
University Hospital Bonn
2025
University of Bonn
2025
Northwestern University
2015-2024
Rush University Medical Center
2016
Universidade Estadual de Campinas (UNICAMP)
2016
Universidade de São Paulo
2016
Universidade Federal de São Paulo
2016
United States Nuclear Regulatory Commission
2016
University of Illinois Chicago
2008-2014
University of North Carolina at Chapel Hill
2005-2013
This study describes a new caregiver-report assessment, the Sensory Experiences Questionnaire (SEQ), and explicates nature of sensory patterns hyper- hyporesponsiveness, their prevalence, developmental correlates in autism relative to comparison groups.Caregivers 258 children five diagnostic groups (Autism, PDD, DD/MR, Other DD, Typical) ages 5-80 months completed SEQ.The SEQ's internal consistency was alpha' = .80. Prevalence overall symptoms for Autism group 69%. were inversely related...
ABSTRACT The effects of progressive resistance exercise (PRE) on the motor signs Parkinson's disease have not been studied in controlled trials. objective current trial was to compare 6‐, 12‐, 18‐, and 24‐month outcomes patients with who received PRE a stretching, balance, strengthening program. authors conducted randomized between September 2007 July 2011. Pairs matched by sex off‐medication scores Unified Disease Rating Scale, subscale (UPDRS‐III), were randomly assigned interventions 1:1...
Abstract This cross-sectional study seeks to (a) describe developmental correlates of sensory hyporesponsiveness social and nonsocial stimuli, (b) determine whether is generalized across contexts in children with autism relative controls, (c) test the associations between communication outcomes. Three groups ages 11–105 months ( N = 178; 63, delay 47, typical development 68) are given measures including a behavioral orienting task (the Sensory Processing Assessment). Lab significantly...
The nature of hyperresponsiveness to sensory stimuli in children with autism, using a new observational measure, the SPA, was examined. Three groups young participants were assessed (autism, developmental delay, typical). Across all groups, MA predictor hyperresponsiveness, such that aversion multisensory toys decreased as increased. two clinical displayed higher levels than typical group. did not differ proportion habituating an auditory stimulus; however, nonresponders more prevalent...
Background This article reports on the findings of effect two structured exercise interventions secondary cognitive outcomes that were gathered as part Progressive Resistance Exercise Training in Parkinson's disease (PD) randomized, controlled trial. Methods study was a prospective, parallel-group, single-center Fifty-one nondemented patients with mild-to-moderate PD randomly assigned either to modified Fitness Counts (mFC) or (PRET) and followed for 24 months. Cognitive Digit Span, Stroop,...
Background and Purpose: No longitudinal study on sensory processing in children with fragile X syndrome (FXS) exists. This examined developmental trajectories correlates of from infancy through preschool years 13 boys FXS.Method: Participants were assessed using observational parent-report measures 2–6 times between 9 54 months age.Results: Over time, an increasing proportion displayed that differed significantly test norms. Observational more sensitive than parent-reports early infancy. Age...
We evaluated the psychometric properties of Sensory Experiences Questionnaire (Version 1; Baranek, David, Poe, Stone, & Watson 2006), a brief caregiver questionnaire for young children with autism and developmental delays used to identify sensory processing patterns in context daily activities.Caregiver questionnaires (N=358) were analyzed determine internal consistency. The test-retest subsample (n=24) completed two assessments within 2-4 wk. Internal consistency reliability using...
Background. The progressive resistance exercise (PRE) in Parkinson’s disease trial (PRET-PD) showed that PRE improved the motor signs of PD compared to a modified Fitness Counts (mFC) program. It is unclear how long-term affects physical function these individuals. Objective. To examine effects and mFC on outcome measures individuals with PD. Methods. A preplanned secondary analysis was conducted using data from 38 patients idiopathic who completed PRET-PD trial. Participants were randomized...
Background and Purpose: This study presents a secondary analysis from the Progressive Resistance Exercise Training in Parkinson Disease (PRET-PD) trial investigating effects of progressive resistance exercise (PRE) disease (PD)-specific multimodal program, modified Fitness Counts (mFC), on spatial, temporal, stability-related gait impairments people with PD. Methods: Forty-eight PD were randomized to participate PRE or mFC 2 times week for 24 months; 38 completed study. Gait velocity, stride...
This study compared the effects of resistance training (RT) and RT with instability (RTI) on neuromuscular total volume (TTV) outcomes obtained as part Instability Resistance Training Trial in Parkinson's disease. It also used a linear multiple regression (forward stepwise method) to identify contribution previously published improvements timed-up-and-go test Unified Disease Rating Scale, motor subscale score.Thirty-nine patients moderate severe disease were randomly assigned three groups:...
In Brief Purpose: This pilot study compared temporal coordination during a precision grip task between 13 children and adolescents with autism spectrum disorders (ASD) who were high functioning peers typical development. Methods: Temporal load forces was measured using latency onset of forces, force at force, peak (PGF), time to PGF. Results: Compared development, participants ASD demonstrated prolonged elevated increased movement variability. PGF not significantly different the 2 groups....
Purpose To determine the extent to which behavioral and physiological responses during child-directed speech (CDS) correlate concurrently predictively with communication skills in young children autism spectrum disorders (ASD). Method Twenty-two boys ASD (initial mean age: 35 months) participated a longitudinal study. At entry, (i.e., percentage looking) vagal activity) measures were collected presentation of CDS stimuli. A battery standardized was administered at entry readministered 12...
Impaired motor coordination is prevalent in children with Autism Spectrum Disorders (ASD) and affects adaptive skills. Little known about the development of patterns young ASD between 2 6 years age. The purpose current study was threefold: 1) to describe developmental correlates ASD, 2) identify extent which deficits are unique by using a control group other disabilities (DD), 3) determine association variables functional fine Twenty-four were compared 30 typical (TD) 11 DD. A precision grip...
In Parkinson's disease (PD), the characteristic triphasic agonist and antagonist muscle activation pattern during ballistic movement is impaired: number of bursts increased, amplitudes are reduced. The breakdown electromyographic (EMG) has been hypothesized to underlie bradykinesia in PD. Progressive resistance exercise shown improve clinical measures bradykinesia, but it not clear whether benefits for accompanied by changes activity. This study examined spatiotemporal activity following 24...
Background:Bilateral priming, device assisted bilateral symmetrical wrist flexion/extension, is a noninvasive neuromodulation technique that can be used in the clinic. Objective:We examined additive effect of motor priming and task specific training individuals with severe upper li mb hemiparesis. Methods:This parallel assignment, single-masked, randomized exploratory pilot study three timepoints (pre-/post-intervention follow up). Participants received either or health care education...
We examined whether previous inconsistent findings about the effect of anti-Parkinsonian medication on visually-guided saccades (VGS) were due to use different paradigms, which change timing fixation offset and target onset, or eccentricities. Thirty-three participants with Parkinson's disease (PD) completed VGS tasks OFF ON medication, along 13 healthy controls. Performance 3 paradigms (gap, step, overlap) 2 eccentricities was recorded. used mixed models determine paradigm, eccentricity...
Bilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease (PD) can have detrimental effects on eye movement inhibitory control. To investigate this effect of bilateral STN DBS, we examined the manipulating DBS amplitude control during antisaccade task. The prosaccade error rate task, that is, directional errors, was indicative impaired We hypothesized as increased, would increase.Ten participants with completed task six different amplitudes (including zero...
We aimed to gain further insight into previously reported beneficial effects of subthalamic nucleus deep brain stimulation (STN-DBS) on visually-guided saccades by examining the unilateral compared bilateral stimulation, paradigm, and target eccentricity in individuals with Parkinson's disease (PD).
The long-term effects of surgery for subthalamic nucleus deep brain stimulation (STN-DBS) on cognitive aspects motor control people with Parkinson's disease (PD) are largely unknown. We compared saccade latency and reach reaction time (RT) pre- post-surgery while participants PD were off-treatment.