A5036108770- Epilepsy research and treatment
- Building materials and conservation
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Conservation Techniques and Studies
- MRI in cancer diagnosis
- Hygrothermal properties of building materials
- Fetal and Pediatric Neurological Disorders
- Functional Brain Connectivity Studies
- Lanthanide and Transition Metal Complexes
- Cerebrovascular and Carotid Artery Diseases
- Memory and Neural Mechanisms
- Amino Acid Enzymes and Metabolism
- Electron Spin Resonance Studies
- Cultural Heritage Materials Analysis
- Medieval Architecture and Archaeology
- Trace Elements in Health
- Pharmacological Effects and Toxicity Studies
- Medical Imaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
University Hospital Bonn
2021-2024
German Center for Neurodegenerative Diseases
2020-2023
University of Bonn
2020-2021
Universität Innsbruck
2021
Abstract Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, date, alterations metabolism brain have not been addressed detail. Iron-related neuropathology and antioxidant metabolic processes were investigated resected tissue from patients temporal lobe epilepsy hippocampal sclerosis (TLE-HS), post-mortem who died after status epilepticus (SE) as...
Automated detection of lesions using artificial intelligence creates new standards in medical imaging. For people with epilepsy, automated focal cortical dysplasias (FCDs) is widely used because subtle FCDs often escape conventional neuroradiological diagnosis. Accurate recognition FCDs, however, outstanding importance for affected people, as surgical resection the dysplastic cortex associated a high chance postsurgical seizure freedom. Here, we make publicly available dataset 85 by epilepsy...
Abstract Blood–brain barrier (BBB) permeability assessment remains of ongoing interest in clinical practice and research. Transitions between intravascular (IV) extravascular (EV) gray matter (GM) compartments may provide information regarding the microstructural status BBB. Due to different transverse relaxation times ( T 2 ) water protons vessels GM, it is possible determine compartment which these are located. This work presents investigates feasibility a simplified analytical approach...
Neuroinflammation evaluation after acute ischemic stroke is a promising option for selecting an appropriate post-stroke treatment strategy. To assess neuroinflammation in vivo, translocator protein PET (TSPO PET) can be used. However, the gold standard TSPO quantification method includes 90 min scan and continuous arterial blood sampling, which challenging to perform on routine basis. In this work, we determine what information required simplified approach using machine learning algorithm....
The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of tissue. Brain changes, due aging, an intervention, or neurodegenerative diseases for example, could be investigated in longitudinal ASL studies reliable sequences. Generally, pseudo-continuous (pCASL) is preferred because its larger signal-to-noise ratio (SNR) compared pulsed (PASL)...
Renders, plasters and masonry mortars based on natural hydraulic lime (NHL) are very common materials in the alpine area of Tyrol as shown by numerous application fields cultural heritage preservation building sites. A sufficient resistance to frost damage crystallization salts most important requirements regard a long-term durability critical environments. Up now, literature provides different types frost-thaw salt testing methods, but not perspicuously tailored for NHL- or lime-based...
Abstract Arterial spin labeling (ASL) is increasingly applied for cerebral blood flow mapping, but $${\text{T}}_{{2}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msub> <mml:mtext>T</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math> relaxation of the ASL signal magnetization often ignored, although it may be clinically relevant. To investigate extent, to which quantitative values in gray matter (GM) obtained by pseudocontinuous (pCASL) perfusion MRI can reproduced,...
Natural hydraulic lime (NHL) is a common binder material in historic mortars and becomes increasingly used recent restoration works for the preservation of cultural heritage. These plasters, renders masonry are suitable applications, where elevated water permeable characteristics required. At building site different workmanship methods may be used, which can simulated by e.g. mixing times. Hence, within present study two NHL-based recipes using hydrated origin (dry powder putty suspension)...
Objective To assess whether arterial spin labeling perfusion images of healthy controls can enhance ictal single‐photon emission computed tomography analysis and the acquisition interictal image be omitted. Methods We developed 2 pipelines: The first uses compares these to controls. second pipeline only analogous Both pipelines were compared gold standard evaluated on data individuals with epilepsy who underwent imaging during presurgical evaluation between 2010 2022. Fifty prospectively...
Abstract Hippocampal volumetry is an essential tool in researching and diagnosing mesial temporal lobe epilepsy (mTLE). However, it has a limited ability to detect subtle alterations hippocampal morphometry. Here, we establish apply novel geometry‐based that enables point‐wise morphometric analysis based on intrinsic coordinate system of the hippocampus. We hypothesized this uncovers structural not measurable by volumetry, but associated with histological underpinnings neuropsychological...
Abstract Well preserved mortars based on natural hydraulic lime are widely spread in historical buildings throughout the alpine area of Tyrol, Austria. These frequently restored with oriented models. Portland cement is also commonly used to modify these materials building sites speed up setting time improve early frost-thaw resistance, primarily when they applied around winter season. Therefore, it was our objective specify application potentials those materials, respecting intended use and...
Here, we report a consanguineous family harboring novel homozygous frame-shift mutation in ASPM leading to truncation of the protein after amino acid position 1830. The phenotype patients was associated with microcephaly, epilepsy, and behavioral cognitive deficits. Despite obvious genetic similarity, affected show considerable phenotypic heterogeneity regarding degree mental retardation, presence epilepsy MRI findings. Interestingly, retardation correlates well severity abnormalities...
&lt;p&gt;For a long time, historical mortars were primarily associated with based on calcium carbonate as the main binder phase. Recent publications show that considerable amounts of magnesium are often present in mortars, which is referred to use dolomite rock raw material (Diekamp, &amp;#8203;&amp;#8203;2009; Diekamp, &amp;#8203;&amp;#8203;2014). A special feature Roman and medieval dolomitic lime addition brick fragments pozzolanic component (Schidlowski, 2019).In...