A5011259506- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Fetal and Pediatric Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- RNA regulation and disease
- Cerebral Palsy and Movement Disorders
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Spinal Dysraphism and Malformations
- Radiomics and Machine Learning in Medical Imaging
- Trace Elements in Health
- Obsessive-Compulsive Spectrum Disorders
- RNA Interference and Gene Delivery
- Neurological and metabolic disorders
- MicroRNA in disease regulation
- Evolutionary Psychology and Human Behavior
- Genetic Neurodegenerative Diseases
- Peripheral Neuropathies and Disorders
- Barrier Structure and Function Studies
- Infectious Encephalopathies and Encephalitis
- Alzheimer's disease research and treatments
University Hospital Bonn
2019-2024
University of Bonn
2016-2023
Vrije Universiteit Amsterdam
2021
Osnabrück University
2020
Epilepsy has been associated with a dysfunction of the blood-brain barrier. While there is ample evidence that barrier contributes to epileptogenesis, as consequence single epileptic seizures not systematically investigated. We hypothesized temporally and anatomically in patients used newly-established quantitative MRI protocol test our hypothesis. Twenty-three epilepsy undergoing inpatient monitoring part their presurgical evaluation were included this study (10 females, mean age ± standard...
Abstract Objective Focal cortical dysplasias (FCDs) are a common cause of drug‐resistant focal epilepsy but frequently remain undetected by conventional magnetic resonance imaging (MRI) assessment. The visual detection can be facilitated morphometric analysis T1‐weighted images, for example, using the Morphometric Analysis Program (v2018; MAP18), which was introduced in 2005, independently validated its clinical benefits, and successfully integrated standard presurgical workflows numerous...
Abstract Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, date, alterations metabolism brain have not been addressed detail. Iron-related neuropathology and antioxidant metabolic processes were investigated resected tissue from patients temporal lobe epilepsy hippocampal sclerosis (TLE-HS), post-mortem who died after status epilepticus (SE) as...
Automated detection of lesions using artificial intelligence creates new standards in medical imaging. For people with epilepsy, automated focal cortical dysplasias (FCDs) is widely used because subtle FCDs often escape conventional neuroradiological diagnosis. Accurate recognition FCDs, however, outstanding importance for affected people, as surgical resection the dysplastic cortex associated a high chance postsurgical seizure freedom. Here, we make publicly available dataset 85 by epilepsy...
Abstract Objective Interictal blood–brain barrier dysfunction in chronic epilepsy has been demonstrated animal models and pathological specimens. Ictal shown humans vivo using an experimental quantitative magnetic resonance imaging (MRI) protocol. Here, we hypothesized that interictal is also present people with drug‐resistant epilepsy. Methods Thirty‐nine (21 females, mean age at MRI ± SD = 30 8 years) were prospectively recruited underwent T1‐relaxometry before after administration of a...
Abstract Humans display an intriguing propensity to help the victim of social norm violations or punish violators which require theory-of-mind (ToM)/mentalizing abilities. The hypothalamic peptide oxytocin (OXT) has been implicated in modulating various pro-social behaviors/perception including trust, cooperation and empathy. However, it is still elusive whether OXT also influences neural responses during third-party altruistic decisions, especially ToM-related brain regions such as...
Oligonucleotide therapies offer precision treatments for a variety of neurological diseases, including epilepsy, but their deployment is hampered by the blood-brain barrier (BBB). Previous studies showed that intracerebroventricular injection an antisense oligonucleotide (antagomir) targeting microRNA-134 (Ant-134) reduced evoked and spontaneous seizures in animal models epilepsy. In this study, we used assays serum protein tracer extravasation to determine BBB disruption occurring after...
Abstract Third-party altruistic decision-making has been shown to be modulated by other-regarding attention (e.g., focusing on the offender’s crime or victim’s situation especially in judicial judgment). However, neural mechanisms underlying this modulation remain poorly understood. In fMRI study, participants voluntarily decided if they wanted punish first-party offender help second-party victim using their own monetary endowment an unfair context. Particularly, before deciding were asked...
Summary Rasmussen encephalitis ( RE ) is an immune‐mediated brain disease with progressive unihemispheric atrophy. Although it regarded as a strictly one‐sided pathology, volumetric magnetic resonance imaging MRI) studies have revealed atrophy in the so‐called unaffected hemisphere. In contrast to previous studies, we hypothesized that contralesional hemisphere would show increased gray matter volume response ipsilesional We assessed differences among 21 patients chronic, late‐stage and 89...
Abstract Motor function after hemispheric lesions has been associated with the structural integrity of either pyramidal tract (PT) or alternate motor fibers (aMF). In this study, we aimed to differentially characterize roles PT and aMF in compensation by relating diffusion-tensor-imaging-derived parameters white matter microstructure measures proximal distal patients hemispherotomy. Twenty-five (13 women; mean age: 21.1 years) hemispherotomy (at 12.4 underwent Diffusion Tensor Imaging...
<h3>BACKGROUND AND PURPOSE:</h3> Limbic encephalitis is an autoimmune disease. A variety of autoantibodies have been associated with different subtypes limbic encephalitis, whereas its MR imaging signature uniformly characterized by mesiotemporal abnormalities across subtypes. Here, we hypothesized that patients would show subtype-specific structural correlates, which could be classified supervised machine learning on individual level. <h3>MATERIALS METHODS:</h3> T1WI MPRAGE scans from 46...
Limbic encephalitis (LE) is an autoimmune syndrome often associated with temporal lobe epilepsy. Recent research suggests that particular structural changes in LE depend on the type of antibody and occur both mesiotemporal gray matter white regions. However, it remains questionable to what degree conventional diffusion tensor imaging (DTI)-methods reflect alterations microstructure, since these methods do not account for crossing fibers. To address this methodological shortcoming, we applied...
Abstract Limbic encephalitis (LE) forms a spectrum of autoimmune diseases involving temporal lobe epilepsy and memory impairment. Imaging features LE are known to depend on the associated antibody occur brain network level. However, first studies investigating networks in have either focused one distinct subgroup or anatomical regions. In this study, graphs 17 patients with autoantibodies against glutamic acid decarboxylase 65 (GAD‐LE), four leucine‐rich glioma‐inactivated 1, five...
Cognitive effort and self-control are exhausting. Although evidence is ambiguous, behavioural studies have repeatedly suggested that control-demanding tasks seem to deplete a limited cache of self-regulatory resources leading performance degradations fatigue. While resource depletion has indirectly been associated with decline in right prefrontal cortex capacity, its precise neural underpinnings not yet revealed. This study consisted two independent experiments, which set out investigate the...
Rasmussen encephalitis (RE) is characterized by its unilateral cerebral involvement. However, both ipsi- and contralesional cerebellar atrophy have been anecdotally reported raising questions about the nature extent of infratentorial findings. Using MRI, we morphometrically investigated cerebellum hypothesized abnormalities beyond effects secondary atrophy, implicating a primary involvement RE.Voxel-based morphometry brainstem was conducted in 57 patients with RE matched controls....
Abstract Selective amygdalohippocampectomy is an effective treatment for patients with therapy-refractory temporal lobe epilepsy but may cause visual field defect (VFD). Here, we aimed to describe tissue-specific pre- and postoperative imaging correlates of the VFD severity using whole-brain analyses from voxel- network-level. Twenty-eight underwent MRI (T1-MPRAGE Diffusion Tensor Imaging) as well kinetic perimetry according Goldmann standard. We probed gray matter (GM) white (WM)...
Alzheimer's disease is regarded as a synaptopathy with long presymptomatic phase. Soluble, oligomeric amyloid beta (Aβ) thought to play causative role in this disease, which eventually leads cognitive decline. However, most animal studies have employed mice expressing high levels of the precursor protein (APP) transgene drive pathology. Here, understand how principal neurons different brain regions cope moderate, chronically present Aβ, we transgenic equal mouse and human APP carrying...
Cerebral lesions may cause degeneration and neuroplastic reorganization in both the ipsi- contralesional hemisphere, presumably creating an imbalance of primarily inhibitory interhemispheric influences produced via transcallosal pathways. The two hemispheres are thought to mutually hamper other hemisphere. results preceding white matter be reflected by Diffusion Tensor Imaging-derived diffusivity parameters such as fractional anisotropy (FA). In this study, we applied Imaging (DTI) contrast...
Abstract Objective Using multimodal imaging, we tested the hypothesis that patients after hemispherotomy recruit non‐primary motor areas and non‐pyramidal descending fibers to restore function of impaired limb. Methods Functional structural MRI data were acquired in a group 25 who had undergone matched healthy controls. Patients’ impairment was measured using Fugl‐Meyer Motor Assessment. Cortical governing upper extremity motor‐control identified by task‐based functional MRI. The resulting...
Deficits in social functioning and decision-making are well-documented schizophrenia, but their relationship with positive symptoms conflicts is poorly understood. We created a new paradigm based on the Dictator Game (DG) to explore differences between individuals experiencing high levels of psychotic-like experiences (PLEs), particularly hallucinations delusions, controls less PLEs.
Abstract Progressive inflammation of one hemisphere characterises Rasmussen’s encephalitis (RE), but contralesional epileptiform activity has been repeatedly reported. We aimed to quantify in RE and uncover its functional structural underpinnings. retrospectively ascertained people with treated between 2000 2018 at a tertiary centre (Centre 1) reviewed all available EEG datasets. The temporal occurrence preoperative (interictal/ictal) was evaluated using mixed-effects logistic regression....
Focal cortical dysplasia (FCD) is a common cause of drug-resistant focal epilepsy but can be challenging to detect visually on magnetic resonance imaging. Three artificial intelligence models for automated FCD detection are publicly available (MAP18, deepFCD, MELD) have only been compared single-center data. Our first objective compare them independent multicenter test Additionally, we train and three new make available.