A5073092397- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Microtubule and mitosis dynamics
- Prion Diseases and Protein Misfolding
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Image Analysis Techniques
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects and Toxicity Studies
- Cognitive Science and Mapping
- Computational Drug Discovery Methods
- Epilepsy research and treatment
- Dementia and Cognitive Impairment Research
- Spatial Cognition and Navigation
- Protein Structure and Dynamics
Osnabrück University
2014-2020
Laboratoire de Neurosciences Cognitives et Adaptatives
2013-2015
Université de Strasbourg
2015
Centre National de la Recherche Scientifique
2013-2015
Efficient spatial navigation relies on the hippocampus integrating local (proximal) and global (distal) cues, collectively called frames of reference, to guide behavior support memory. Although these cues control anchoring principal cell fields, how tune interneuron functions remains unknown. Traditionally, interneurons such as O-LM VIP cells have been viewed primarily speed encoders, although some also encode information or respond discrete stimuli. Using calcium imaging in freely behaving...
Dendritic spines represent the major postsynaptic input of excitatory synapses. Loss and changes in their morphology correlate with cognitive impairment Alzheimer's disease (AD) are thought to occur early during pathology. Therapeutic intervention at a preclinical stage AD modify spine might thus be warranted. To follow development potentially interfere over time, we established long term ex vivo model from organotypic cultures hippocampus APP transgenic control mice. The exhibit loss...
Dendritic simplification, a key feature of the neurodegenerative triad Alzheimer's disease (AD) in addition to spine changes and neuron loss, occurs region-specific manner. However, it is unknown how dendritic complexity are mediated they relate loss. To investigate mechanisms simplification an authentic CNS environment we employed ex vivo model, based on targeted expression enhanced green fluorescent protein (EGFP)-tagged constructs organotypic hippocampal slices mice. Algorithm-based 3D...
Summary Purpose Administration of carisbamate during status epilepticus ( SE ) prevents the occurrence motor seizures in lithium–pilocarpine model and leads a subpopulation rats to spike‐and‐wave discharges characteristic absence epilepsy. Widespread neuroprotection accompanied this change seizure expression. To assess whether these carisbamate‐induced changes affected comorbidity, we used large battery behavioral tests that had developed temporal lobe or absence‐like seizures. Methods...
DMSO has a widespread use as vehicle for water-insoluble therapeutic drug candidates but may also exert disease-relevant pharmacological effects by itself. However, its influence on the CNS hardly been addressed. Here we examined brain structure and function following chronic exposure to low dose at paradigm with flawed synaptic connectivity in preclinical transgenic mouse model Alzheimer's disease (APPSDL mice). treatment increased spine density region-specific manner hippocampus of APPSDL...
Alzheimer's disease is regarded as a synaptopathy with long presymptomatic phase. Soluble, oligomeric amyloid beta (Aβ) thought to play causative role in this disease, which eventually leads cognitive decline. However, most animal studies have employed mice expressing high levels of the precursor protein (APP) transgene drive pathology. Here, understand how principal neurons different brain regions cope moderate, chronically present Aβ, we transgenic equal mouse and human APP carrying...