A5055672968- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Genetics and Neurodevelopmental Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Hydrogen's biological and therapeutic effects
- Nicotinic Acetylcholine Receptors Study
- Epilepsy research and treatment
- Histone Deacetylase Inhibitors Research
- Eating Disorders and Behaviors
- Dementia and Cognitive Impairment Research
- Developmental and Educational Neuropsychology
- Regulation of Appetite and Obesity
- Anesthesia and Neurotoxicity Research
- Radiopharmaceutical Chemistry and Applications
- Tryptophan and brain disorders
Laboratoire de Neurosciences Cognitives et Adaptatives
2013-2023
Centre National de la Recherche Scientifique
2007-2023
Université de Strasbourg
2009-2023
Alexandra Institute (Denmark)
2013
Laboratoire de Neurosciences Cognitives
2007-2009
Cyceron
1995-2004
University of Eastern Finland
2001-2002
Université de Caen Normandie
1998-1999
Laboratoire National Henri Becquerel
1995
Aging weakens memory functions. Exposing healthy rodents or pathological rodent models to environmental enrichment (EE) housing improves their cognitive functions by changing neuronal levels of excitation, cellular signaling, and plasticity, notably in the hippocampus. At molecular level, brain derived-neurotrophic factor (BDNF) represents an important player that supports EE-associated changes. EE facilitation learning was also shown correlate with chromatin acetylation It is not known,...
The recent literature provides evidence that epigenetic mechanisms such as DNA methylation and histone modification are crucial to gene transcription linked synaptic plasticity in the mammalian brain--notably hippocampus--and memory formation. We measured global acetylation levels rat hippocampus at an early stage of spatial or fear found H3, H4 H2B underwent differential specific sites depending on whether rats had been exposed context a task without having learn about place therein:...
Working memory is a cognitive ability allowing the temporary storage of information to solve problems or adjust behavior. While working known mainly depend on medial prefrontal cortex (mPFC), very few about how cortical are relayed subcortically. By its connectivity, lateral habenula (lHb) might act as subcortical relay for information. Indeed, lHb receives inputs from several mPFC subregions, and recent findings suggest role in online processing spatial information, fundamental aspect...
Summary Objective Temporal lobe epilepsy is a relatively frequent, invalidating, and often refractory neurologic disorder. It associated with cognitive impairments that affect memory executive functions. In the rat lithium‐pilocarpine temporal model, impairment anxiety disorder are classically reported. Here we evaluated sustained visual attention in this model of epilepsy, function not frequently explored. Methods Thirty‐five Sprague‐Dawley rats were subjected to status epilepticus. Twenty...
Rats with a deficit in selective attention accompanied by impulsivity can be identified using five-choice serial reaction time task (5-CSRT) and have been proposed to represent rodent model of attention-deficit hyperactivity disorder (ADHD). The aim the present study was investigate which brain areas are important for visuospatial test specific hypothesis that dysfunction frontal cortex is related behavioral deficits observed poorly performing rats. Therefore, [14C]deoxyglucose (DG) uptake,...
Recent studies have shown that the integrity of entorhinal cortex (EC) is not required for simple contextual conditioning. In background conditioning, i.e., when a phasic cue present during training, involvement EC still matter debate. Therefore, work further examines whether conditioning using tone as cue. Rats sustaining either excitotoxic lesions or sham-lesions were trained with one two procedures differing respect to predictive value tone: paired procedure in which perfectly predicts...
Cocaine exposure induces changes in the expression of numerous genes, part through epigenetic modifications. We have initially shown that cocaine increases chromatin remodeling protein methyl-CpG binding 2 (MeCP2) and characterized phosphatase-1Cβ (PP1Cβ) gene, as repressed by passive i.p. injections a Mecp2-mediated mechanism involving de novo DNA methylation. Both proteins being involved learning memory processes, we investigated whether voluntary administration would similarly affect...
Upon stress exposure, a broad network of structures comes into play in order to provide adequate responses and restore homeostasis. It has been known for decades that the main engaged during response are medial prefrontal cortex, amygdala, hippocampus, hypothalamus, monoaminergic systems (noradrenaline, dopamine serotonin) periaqueductal gray. The lateral habenula (LHb) is an epithalamic structure directly connected cortical areas whereas it functionally interacts with hippocampus. Also,...
Exposure of rodents to a stimulating environment has beneficial effects on some cognitive functions that are impaired during physiological aging, and especially spatial reference memory. The present study investigated whether environmental enrichment rescues these in already declining subjects and/or protects them from subsequent decline. Subgroups 17-mo-old female rats with unimpaired versus performance memory task (Morris water maze) were housed until the age 24 mo standard or enriched...
To determine if the inhibition of MAO-A and/or MAO-B activities can influence cognitive processes in adult rats, we analysed whether chronic treatment with clorgyline, 1-deprenyl and pargyline could modify performance rats a modified version water maze task. The effects these treatments on locomotor activity enzyme were also assessed. Rats treated for 24 days clorgyline (0.2 mg/kg), (0.25 mg/kg) (I or 10 mg/kg). started two weeks before experiment continued until end testing. trained to find...