A5002414770- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- GABA and Rice Research
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Eicosanoids and Hypertension Pharmacology
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Maternal Mental Health During Pregnancy and Postpartum
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pharmacogenetics and Drug Metabolism
National Institute of Mental Health
2021-2025
The University of Texas Health Science Center at San Antonio
2009-2024
Scripps Research Institute
2015
Virginia Commonwealth University Medical Center
2015
The University of Texas System
2009
Audie L. Murphy Memorial VA Hospital
2009
Laboratoire de Neurosciences Cognitives
2000-2007
Centre National de la Recherche Scientifique
2000-2005
Université de Strasbourg
2005
Humans report a wide range of neurobiological rewards following moderate and intense aerobic activity, popularly referred to as the 'runner's high', which may function encourage habitual exercise. Endocannabinoids (eCBs) are endogenous neurotransmitters that appear play major role in generating these by activating cannabinoid receptors brain reward regions during after Other species also regularly engage endurance exercise (cursorial mammals), humans share many morphological traits with...
Abstract Parkinson’s disease (PD) is characterized by the progressive loss of nigrostriatal dopamine neurons leading to motor disturbances and cognitive impairment. Current pharmacotherapies relieve PD symptoms temporarily but fail prevent or slow down progression. In this study, we investigated molecular mechanisms which non‐selective cannabinoid receptor agonist WIN55,212‐2 (WIN) protects mouse from 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced neurotoxicity...
The ‘cannabinoid hypothesis’ of schizophrenia tulates that over-activity the endocannabinoid system might contribute to aetiology schizophrenia. In keeping with this hypothesis, increased expression CB1 receptors, elevation anandamide (AEA) and cannabinoid-induced cognitive changes have been reported in animal models psychotic patients. study we measured brain levels [35S]GTPγS binding stimulated by CB receptor agonist CP55,940 rats undergoing withdrawal from subchronic administration...
Recent studies have shown that the integrity of entorhinal cortex (EC) is not required for simple contextual conditioning. In background conditioning, i.e., when a phasic cue present during training, involvement EC still matter debate. Therefore, work further examines whether conditioning using tone as cue. Rats sustaining either excitotoxic lesions or sham-lesions were trained with one two procedures differing respect to predictive value tone: paired procedure in which perfectly predicts...
Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) inhibitors exert preclinical effects indicative of therapeutic potential (i.e., analgesia). However, the extent to which MAGL FAAH produce unwanted remains unclear. Here, inhibition was examined separately together in a Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC; 5.6 mg/kg i.p.) discrimination assay predictive subjective associated with cannabis use, relative contribution <i>N</i>-arachidonoyl ethanolamine (AEA)...
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of negative symptoms schizophrenia, results from deficits brain endocannabinoid transmission. As cannabis intake has been shown to affect negatively course and expression psychosis, we tested whether beneficial effects endocannabinoid-mediated CB1 activation on social PCP-treated rats (5 mg/kg, twice daily for 7 days)also occurred after administration Δ9-tetrahydrocannabinol (THC; 0.1, 0.3, 1.0 i.p.)....
Abstract Latent inhibition (LI), that is the decrease in conditioned response induced by repeated nonreinforced pre‐exposures to to‐be‐conditioned stimulus, disrupted entorhinal cortex (EC) lesions. The mechanism involved this disruption unknown, and particular experimental stage (pre‐exposure or conditioning) at which integrity of EC necessary has be determined. purpose study was address issue using reversible inactivation local micro‐infusion tetrodotoxin (TTX). TTX infused either before...
Dopamine release within the nucleus accumbens shell is suggested to control salience of environmental stimuli, and previous research has shown that indirect dopamine agonist D-amphetamine can alter both aversive neutral stimuli. In experiment 1, effect systemic injection (0.5, 1 mg/kg) on fear conditioning a tone was assessed in an 'off-baseline' conditioned suppression procedure using several footshock intensities. Although effects amphetamine were unclear, results indicated deficit simple...
Social withdrawal should not be considered a direct measure of the negative symptoms schizophrenia as it may result only from asociality (primary symptom) but also other altered processes such anxiety. To understand contribution these two factors to social deficit, we investigated whether observed in subchronic phencyclidine (PCP) rat model could attributed increased Compared saline controls, PCP-treated rats (5 mg/kg, twice daily for 7 days, followed by washout period) spent significantly...