A5029674930- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Pharmacological Effects and Toxicity Studies
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Rabbits: Nutrition, Reproduction, Health
- Memory and Neural Mechanisms
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Cerebrovascular and Carotid Artery Diseases
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Neurology and Historical Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Chemical and Physical Studies
- Medical research and treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Menstrual Health and Disorders
- Biotin and Related Studies
- Enzyme function and inhibition
Université de Strasbourg
2014-2015
Inserm
1968-2015
Centre National de la Recherche Scientifique
2013-2015
Laboratoire de Neurosciences Cognitives et Adaptatives
2014-2015
EM Strasbourg Business School
2014
Summary Objective Temporal lobe epilepsy is a relatively frequent, invalidating, and often refractory neurologic disorder. It associated with cognitive impairments that affect memory executive functions. In the rat lithium‐pilocarpine temporal model, impairment anxiety disorder are classically reported. Here we evaluated sustained visual attention in this model of epilepsy, function not frequently explored. Methods Thirty‐five Sprague‐Dawley rats were subjected to status epilepticus. Twenty...
Summary Purpose Administration of carisbamate during status epilepticus ( SE ) prevents the occurrence motor seizures in lithium–pilocarpine model and leads a subpopulation rats to spike‐and‐wave discharges characteristic absence epilepsy. Widespread neuroprotection accompanied this change seizure expression. To assess whether these carisbamate‐induced changes affected comorbidity, we used large battery behavioral tests that had developed temporal lobe or absence‐like seizures. Methods...
Summary Objective The Genetic Absence Epilepsy Rats from Strasbourg ( GAERS) is a genetic model, derived Wistar rats by selective breeding. In all previous studies, GAERS were compared to their paired selected strain not expressing spike‐and‐wave discharges SWD s), namely nonepileptic controls NEC s). Because the occurrence/absence of s polygenic origin, some other traits could have been along with s. Therefore, we explored importance using second control group consisting in rats, origin ,...
As reported previously, in the lithium-pilocarpine model of temporal lobe epilepsy (TLE), carisbamate (CRS) produces strong neuroprotection, leads to milder absence-like seizures, and prevents behavioral impairments a subpopulation rats. To understand metabolic basis these effects, here we injected 90 mg/kg CRS or vehicle twice daily for 7 days starting 1 h after status epilepticus (SE) induction Two months later, [1-13 C]glucose [1,2-13 C]acetate followed by head microwave fixation 15 min....